Journal
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1876, Issue 1, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bbcan.2021.188584
Keywords
LncRNAs; Ovarian cancer; Cancer hallmarks; Prognosis, targeted therapy
Categories
Funding
- Russian Foundation for Basic Research [20-015-00157, 18-29-09005]
- Russian Science Foundation [1915-00125]
- Stockholm Cancer Society [181301]
- Swedish Cancer Society [190345]
- Russian Science Foundation [19-15-00125] Funding Source: Russian Science Foundation
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Long non-coding RNAs (lncRNAs) play a significant role in tumor progression, impacting cellular processes and playing a key role in ovarian cancer.
An emerging role of long non-coding RNAs (lncRNAs) in tumor progression has been revealed in the last decade. Through interactions with nucleic acids and proteins, lncRNAs could act as enhancers, scaffolds or decoys for a number of oncoproteins and tumor suppressors. The aberrant lncRNA expression or mutations are often associated with changes in a variety of cellular processes, including proliferation, stress response and cell death. Here, we will focus on the tumor-associated lncRNAs in ovarian cancer according to their contribution to cancer hallmarks, such as intense proliferation, cell death resistance, altered energy metabolism, invasion and metastasis, and immune evasion. Moreover, the potential clinical implications of lncRNAs and their significance for the diagnosis, prognosis and therapy of ovarian cancer will be discussed.
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