Increasing global access to the high-volume HIV drug nevirapine through process intensification

Total synthesis of triazole-linked C-glycosyl flavonoids in alternative solvents and environmental assessment in terms of reaction, workup and purification

(2016) Freddy Pessel et al.   GREEN CHEMISTRY

Sustainable synthesis of enantiopure fluorolactam derivatives by a selective direct fluorination – amidase strategy

(2016) Nicky J. Willis et al.   GREEN CHEMISTRY

Time Economical Total Synthesis of (−)-Oseltamivir

(2016) Yujiro Hayashi et al.   ORGANIC LETTERS

Development of an Efficient, Safe, and Environmentally Friendly Process for the Manufacture of GDC-0084

(2016) Andreas Stumpf et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system

(2016) A. Adamo et al.   SCIENCE

Overcoming barriers to green chemistry in the pharmaceutical industry – the Green Aspiration Level™ concept

(2015) F. Roschangar et al.   GREEN CHEMISTRY

Synthesis and Reactivity Profile of Ylidenemalononitrile Enamines and Their Ester Analogs Towards Electrophiles and Nucleophiles

(2015) Ashley R. Longstreet et al.   JOURNAL OF ORGANIC CHEMISTRY

Pharmaceutical Process Chemistry: Evolution of a Contemporary Data-Rich Laboratory Environment

(2015) Stéphane Caron et al.   JOURNAL OF ORGANIC CHEMISTRY

Continuous Synthesis of Organozinc Halides Coupled to Negishi Reactions

(2014) Nerea Alonso et al.   ADVANCED SYNTHESIS & CATALYSIS

A Three-Minute Synthesis and Purification of Ibuprofen: Pushing the Limits of Continuous-Flow Processing

(2014) David R. Snead et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Practical preparation of challenging amides from non-nucleophilic amines and esters under flow conditions

(2014) Johannes L. Vrijdag et al.   CHEMICAL COMMUNICATIONS

Life Cycle Analysis within Pharmaceutical Process Optimization and Intensification: Case Study of Active Pharmaceutical Ingredient Production

(2014) Denise Ott et al.   ChemSusChem

Synthesis of a Nucleoside Phosphoramidate Prodrug Inhibitor of HCV NS5B Polymerase: Phenylboronate as a Transient Protecting Group

(2014) Benjamin A. Mayes et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine

(2013) Ashley R Longstreet et al.   Beilstein Journal of Organic Chemistry

Applying Flow Chemistry: Methods, Materials, and Multistep Synthesis

(2013) D. Tyler McQuade et al.   JOURNAL OF ORGANIC CHEMISTRY

Continuous Synthesis and Use of N-Heterocyclic Carbene Copper(I) Complexes from Insoluble Cu2O

(2013) Suzanne M. Opalka et al.   ORGANIC LETTERS

Improved Synthesis of Mono- and Disubstituted 2-Halonicotinonitriles from Alkylidene Malononitriles

(2013) Ashley R. Longstreet et al.   ORGANIC LETTERS

Development of a Robust and Sustainable Process for Nucleoside Formation

(2013) Fabrice Gallou et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Pharmaceutical Roundtable Study Demonstrates the Value of Continuous Manufacturing in the Design of Greener Processes

(2013) Peter Poechlauer et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin

(2012) François Lévesque et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Eight Criteria Defining a Good Chemical Manufacturing Process

(2012) Rolf Dach et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

How do the fine chemical, pharmaceutical, and related industries approach green chemistry and sustainability?

(2011) William J. W. Watson   GREEN CHEMISTRY

The Safe Use of Sodium Hydride on Scale: The Process Development of a Chloropyrimidine Displacement

(2011) Jamie M. McCabe Dunn et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Key Green Engineering Research Areas for Sustainable Manufacturing: A Perspective from Pharmaceutical and Fine Chemicals Manufacturers

(2011) Concepción Jiménez-González et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Using the Right Green Yardstick: Why Process Mass Intensity Is Used in the Pharmaceutical Industry To Drive More Sustainable Processes

(2011) Concepcion Jimenez-Gonzalez et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Chemical Process Research and Development in the 21st Century: Challenges, Strategies, and Solutions from a Pharmaceutical Industry Perspective

(2009) Hans-Jürgen Federsel   ACCOUNTS OF CHEMICAL RESEARCH