Journal
ORGANIC LETTERS
Volume 15, Issue 20, Pages 5298-5301Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol4025265
Keywords
-
Categories
Funding
- Clinton Health Access Initiative
- Corning Glass, Inc.
Ask authors/readers for more resources
Pyridines with 2,3,4 and/or 5 substitution remain challenging to prepare. Existing strategies to form multisubstituted 2-halonicotinonitriles via enamines suffer from dimerization of the starting alkylidene malononitriles resulting in low yields. Through alteration of reaction conditions, a new high yielding method into enamines was realized by condensing DMF-DMA and alkylidene malononitriles in the presence of substoichiometric acetic anhydride. Cyclization of the resulting enamines under Pinner conditions provided 2-halonicotinonitriles in high overall yields.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available