Current technical approaches to brain energy metabolism

Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements

(2017) Shona A. Mookerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death

(2017) Ajit S. Divakaruni et al.   JOURNAL OF CELL BIOLOGY

Near-critical GLUT1 and Neurodegeneration

(2017) L. Felipe Barros et al.   JOURNAL OF NEUROSCIENCE RESEARCH

[18F]FDG PET signal is driven by astroglial glutamate transport

(2017) Eduardo R Zimmer et al.   NATURE NEUROSCIENCE

Upregulated energy metabolism in the Drosophila mushroom body is the trigger for long-term memory

(2017) Pierre-Yves Plaçais et al.   Nature Communications

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

(2017) Philip Hasel et al.   Nature Communications

Monitoring ATP dynamics in electrically active white matter tracts

(2017) Andrea Trevisiol et al.   eLife

Evaluation of a high-resolution micro-sized magic angle spinning (HRμMAS) probe for NMR-based metabolomic studies of nanoliter samples

(2016) Nghia Tuan Duong et al.   Analytical Methods

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

(2016) Philipp Mächler et al.   Cell Metabolism

Cell Proliferation and Cytotoxicity Assays

(2016) Aysun Adan et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

High performance enzyme kinetics of turnover, activation and inhibition for translational drug discovery

(2016) Rumin Zhang et al.   Expert Opinion on Drug Discovery

Exploring cells with targeted biosensors

(2016) Diana Pendin et al.   JOURNAL OF GENERAL PHYSIOLOGY

Two-Photon Absorbing Phosphorescent Metalloporphyrins: Effects of π-Extension and Peripheral Substitution

(2016) Tatiana V. Esipova et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Apollo-NADP+: a spectrally tunable family of genetically encoded sensors for NADP+

(2016) William D Cameron et al.   NATURE METHODS

Astroglial glutamate transporters coordinate excitatory signaling and brain energetics

(2016) Michael B. Robinson et al.   NEUROCHEMISTRY INTERNATIONAL

Astrocytes regulate cortical state switching in vivo

(2016) Kira E. Poskanzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes

(2016) Irene Lopez-Fabuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping oxygen concentration in the awake mouse brain

(2016) Declan G Lyons et al.   eLife

Proteomic analysis of the postsynaptic density implicates synaptic function and energy pathways in bipolar disorder

(2016) M Föcking et al.   Translational Psychiatry

The contributions of respiration and glycolysis to extracellular acid production

(2015) Shona A. Mookerjee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

A roadmap for interpreting 13 C metabolite labeling patterns from cells

(2015) Joerg M Buescher et al.   CURRENT OPINION IN BIOTECHNOLOGY

Phototransduction Influences Metabolic Flux and Nucleotide Metabolism in Mouse Retina

(2015) Jianhai Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hemichannel-mediated release of lactate

(2015) Anastassios Karagiannis et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Metabolic Profiling and Phenotyping of Central Nervous System Diseases: Metabolites Bring Insights into Brain Dysfunctions

(2015) Marc-Emmanuel Dumas et al.   Journal of Neuroimmune Pharmacology

Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

(2015) T. Sotelo-Hitschfeld et al.   JOURNAL OF NEUROSCIENCE

Optogenetic control of endogenous Ca2+ channels in vivo

(2015) Taeyoon Kyung et al.   NATURE BIOTECHNOLOGY

Transgenic Mice for Intersectional Targeting of Neural Sensors and Effectors with High Specificity and Performance

(2015) Linda Madisen et al.   NEURON

NH4+ triggers the release of astrocytic lactate via mitochondrial pyruvate shunting

(2015) Rodrigo Lerchundi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DrosophilaCentral Nervous System Glia

(2015) Marc R. Freeman   Cold Spring Harbor Perspectives in Biology

Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids

(2015) Michael E. Kurczy et al.   Nature Communications

Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

(2015) Iben Lundgaard et al.   Nature Communications

Uncertainties in pentose-phosphate pathway flux assessment underestimate its contribution to neuronal glucose consumption: relevance for neurodegeneration and aging

(2015) Anne-Karine Bouzier-Sore et al.   Frontiers in Aging Neuroscience

Multi-timescale Modeling of Activity-Dependent Metabolic Coupling in the Neuron-Glia-Vasculature Ensemble

(2015) Renaud Jolivet et al.   PLoS Computational Biology

Comparative analysis of optogenetic actuators in cultured astrocytes

(2014) Melina Figueiredo et al.   CELL CALCIUM

Astrocyte-neuron crosstalk regulates the expression and subcellular localization of carbohydrate metabolism enzymes

(2014) Piotr Mamczur et al.   GLIA

Impaired Brain Energy Metabolism in the BACHD Mouse Model of Huntington's Disease: Critical Role of Astrocyte–Neuron Interactions

(2014) Lydie Boussicault et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Synthesis of Phosphorescent Asymmetrically π-Extended Porphyrins for Two-Photon Applications

(2014) Tatiana V. Esipova et al.   JOURNAL OF ORGANIC CHEMISTRY

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport

(2014) Chendong Yang et al.   MOLECULAR CELL

A Computational Model of Motor Neuron Degeneration

(2014) Gwendal Le Masson et al.   NEURON

Norepinephrine Controls Astroglial Responsiveness to Local Circuit Activity

(2014) Martin Paukert et al.   NEURON

Optogenetic Countering of Glial Acidosis Suppresses Glial Glutamate Release and Ischemic Brain Damage

(2014) Kaoru Beppu et al.   NEURON

Imaging Mitochondrial Flux in Single Cells with a FRET Sensor for Pyruvate

(2014) Alejandro San Martín et al.   PLoS One

Socially responsive effects of brain oxidative metabolism on aggression

(2014) H. Li-Byarlay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical Proton MR Spectroscopy in Central Nervous System Disorders

(2014) Gülin Öz et al.   RADIOLOGY

Optogenetic astrocyte activation modulates response selectivity of visual cortex neurons in vivo

(2014) Gertrudis Perea et al.   Nature Communications

Single-cell imaging tools for brain energy metabolism: a review

(2014) Alejandro San Martín et al.   Neurophotonics

In Vivo Fluorescent Adenosine 5′-Triphosphate (ATP) Imaging of Drosophila melanogaster and Caenorhabditis elegans by Using a Genetically Encoded Fluorescent ATP Biosensor Optimized for Low Temperatures

(2013) Taiichi Tsuyama et al.   ANALYTICAL CHEMISTRY

Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage

(2013) Xin Yang et al.   ANNALS OF NEUROLOGY

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

(2013) Haoyi Wang et al.   CELL

Imaging local neuronal activity by monitoring PO2 transients in capillaries

(2013) Alexandre Parpaleix et al.   NATURE MEDICINE

New insights into the classification and nomenclature of cortical GABAergic interneurons

(2013) Javier DeFelipe et al.   NATURE REVIEWS NEUROSCIENCE

Physiological Roles of Aquaporin-4 in Brain

(2013) Erlend A. Nagelhus et al.   PHYSIOLOGICAL REVIEWS

A Genetically Encoded FRET Lactate Sensor and Its Use To Detect the Warburg Effect in Single Cancer Cells

(2013) Alejandro San Martín et al.   PLoS One

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Small is fast: astrocytic glucose and lactate metabolism at cellular resolution

(2013) L. F. Barros et al.   Frontiers in Cellular Neuroscience

Schwann cell glycogen selectively supports myelinated axon function

(2012) Angus M. Brown et al.   ANNALS OF NEUROLOGY

Higher Transport and Metabolism of Glucose in Astrocytes Compared with Neurons: A Multiphoton Study of Hippocampal and Cerebellar Tissue Slices

(2012) P. Jakoby et al.   CEREBRAL CORTEX

Acute feedback control of astrocytic glycolysis by lactate

(2012) T. Sotelo-Hitschfeld et al.   GLIA

Oxidative Phosphorylation, Not Glycolysis, Powers Presynaptic and Postsynaptic Mechanisms Underlying Brain Information Processing

(2012) C. N. Hall et al.   JOURNAL OF NEUROSCIENCE

Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging

(2012) J. Akerboom et al.   JOURNAL OF NEUROSCIENCE

Lactate flux in astrocytes is enhanced by a non-catalytic action of carbonic anhydrase II

(2012) Malin H. Stridh et al.   JOURNAL OF PHYSIOLOGY-LONDON

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells

(2012) Jin Zhang et al.   Nature Protocols

The glutamate transporter, GLAST, participates in a macromolecular complex that supports glutamate metabolism

(2012) Deborah E. Bauer et al.   NEUROCHEMISTRY INTERNATIONAL

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes

(2011) Oleg Palygin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cellular and Metabolic Origins of Flavoprotein Autofluorescence in the Cerebellar Cortex in vivo

(2011) Kenneth C. Reinert et al.   CEREBELLUM

NBCe1 Mediates the Acute Stimulation of Astrocytic Glycolysis by Extracellular K+

(2011) I. Ruminot et al.   JOURNAL OF NEUROSCIENCE

Co-compartmentalization of the Astroglial Glutamate Transporter, GLT-1, with Glycolytic Enzymes and Mitochondria

(2011) E. N. Genda et al.   JOURNAL OF NEUROSCIENCE

Simultaneous two-photon imaging of oxygen and blood flow in deep cerebral vessels

(2011) Jérôme Lecoq et al.   NATURE MEDICINE

Quantitative functional MRI: Concepts, issues and future challenges

(2011) G. Bruce Pike   NEUROIMAGE

High Throughput Microplate Respiratory Measurements Using Minimal Quantities Of Isolated Mitochondria

(2011) George W. Rogers et al.   PLoS One

Lactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing

(2011) Lori A. Newman et al.   PLoS One

Comment on Recent Modeling Studies of Astrocyte–Neuron Metabolic Interactions

(2010) Renaud Jolivet et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

FRET microscopy: from principle to routine technology in cell biology

(2010) A. PIETRASZEWSKA-BOGIEL et al.   JOURNAL OF MICROSCOPY

Differential susceptibility of astrocytic and neuronal function to 3-chloropropanediol in the rat inferior colliculus

(2010) Angus M. Brown et al.   JOURNAL OF NEUROCHEMISTRY

Predominant Enhancement of Glucose Uptake in Astrocytes versus Neurons during Activation of the Somatosensory Cortex

(2010) J. Chuquet et al.   JOURNAL OF NEUROSCIENCE

Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue

(2010) Sava Sakadžić et al.   NATURE METHODS

Lactate levels in the brain are elevated upon exposure to volatile anesthetics: A microdialysis study

(2010) Tobias Horn et al.   NEUROCHEMISTRY INTERNATIONAL

Detection by voxel-wise statistical analysis of significant changes in regional cerebral glucose uptake in an APP/PS1 transgenic mouse model of Alzheimer's disease

(2010) Albertine Dubois et al.   NEUROIMAGE

Astrocytes Control Breathing Through pH-Dependent Release of ATP

(2010) A. V. Gourine et al.   SCIENCE

A Two-Photon Tracer for Glucose Uptake

(2009) Yu Shun Tian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Linking supply to demand: the neuronal monocarboxylate transporter MCT2 and the α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid receptor GluR2/3 subunit are associated in a common trafficking process

(2009) Karin Pierre et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Kinetic validation of 6-NBDG as a probe for the glucose transporter GLUT1 in astrocytes

(2009) Luis Felipe Barros et al.   JOURNAL OF NEUROCHEMISTRY

Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure

(2009) Sung W. Choi et al.   JOURNAL OF NEUROCHEMISTRY

Thein vivoneuron-to-astrocyte lactate shuttle in human brain: evidence from modeling of measured lactate levels during visual stimulation

(2009) Silvia Mangia et al.   JOURNAL OF NEUROCHEMISTRY

Glutamate Transporter Coupling to Na,K-ATPase

(2009) E. M. Rose et al.   JOURNAL OF NEUROSCIENCE

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

Use of NAD(P)H and flavoprotein autofluorescence transients to probe neuron and astrocyte responses to synaptic activation

(2009) C. William Shuttleworth   NEUROCHEMISTRY INTERNATIONAL

Split-Cre Complementation Indicates Coincident Activity of Different Genes In Vivo

(2009) Johannes Hirrlinger et al.   PLoS One

Characterization and performance of a near-infrared 2-deoxyglucose optical imaging agent for mouse cancer models

(2008) Joy L. Kovar et al.   ANALYTICAL BIOCHEMISTRY

Preferential transport and metabolism of glucose in Bergmann glia over Purkinje cells: A multiphoton study of cerebellar slices

(2008) L.F. Barros et al.   GLIA

P2X1 and P2X5 Subunits Form the Functional P2X Receptor in Mouse Cortical Astrocytes

(2008) U. Lalo et al.   JOURNAL OF NEUROSCIENCE

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE

Na+-Ca2+cosignaling in the stimulation of the glucose transporter GLUT1 in cultured astrocytes

(2007) Omar H. Porras et al.   GLIA