What we can learn from a tadpole about ciliopathies and airway diseases: Using systems biology inXenopusto study cilia and mucociliary epithelia

Foxn4 promotes gene expression required for the formation of multiple motile cilia

(2016) Evan P. Campbell et al.   DEVELOPMENT

TAp73 is a central transcriptional regulator of airway multiciliogenesis

(2016) Alice Nemajerova et al.   GENES & DEVELOPMENT

Ciliary transcription factors in cancer - how understanding ciliogenesis can promote the detection and prognosis of cancer types

(2016) Peter Walentek   JOURNAL OF PATHOLOGY

Genome evolution in the allotetraploid frog Xenopus laevis

(2016) Adam M. Session et al.   NATURE

Active DNA demethylation at enhancers during the vertebrate phylotypic period

(2016) Ozren Bogdanović et al.   NATURE GENETICS

Particle streak velocimetry-optical coherence tomography: a novel method for multidimensional imaging of microscale fluid flows

(2016) Kevin C. Zhou et al.   Biomedical Optics Express

p73 Is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network

(2016) Clayton B. Marshall et al.   Cell Reports

Ciliary transcription factors and miRNAs precisely regulate Cp110 levels required for ciliary adhesions and ciliogenesis

(2016) Peter Walentek et al.   eLife

Cilia Dysfunction in Lung Disease

(2015) Ann E. Tilley et al.   Annual Review of Physiology

Gmnc Is a Master Regulator of the Multiciliated Cell Differentiation Program

(2015) Feng Zhou et al.   CURRENT BIOLOGY

BMP signalling controls the construction of vertebrate mucociliary epithelia

(2015) M. Cibois et al.   DEVELOPMENT

Control of vertebrate core planar cell polarity protein localization and dynamics by Prickle 2

(2015) Mitchell T. Butler et al.   DEVELOPMENT

ATP4a is required for development and function of the Xenopus mucociliary epidermis – a potential model to study proton pump inhibitor-associated pneumonia

(2015) Peter Walentek et al.   DEVELOPMENTAL BIOLOGY

CRISPR/Cas9: An inexpensive, efficient loss of function tool to screen human disease genes in Xenopus

(2015) Dipankan Bhattacharya et al.   DEVELOPMENTAL BIOLOGY

The Xenopus ORFeome: A resource that enables functional genomics

(2015) Ian M. Grant et al.   DEVELOPMENTAL BIOLOGY

On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development

(2015) Leonid Peshkin et al.   DEVELOPMENTAL CELL

Morpholinos: Antisense and Sensibility

(2015) Martin Blum et al.   DEVELOPMENTAL CELL

Distinct functionality of dishevelled isoforms on Ca2+/calmodulin-dependent protein kinase 2 (CamKII) in Xenopus gastrulation

(2015) Marc Gentzel et al.   MOLECULAR BIOLOGY OF THE CELL

CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo

(2015) Miguel A Moreno-Mateos et al.   NATURE METHODS

mab21-l3 regulates cell fate specification of multiciliate cells and ionocytes

(2015) Chika Takahashi et al.   Nature Communications

Specialized Cilia in Mammalian Sensory Systems

(2015) Nathalie Falk et al.   Cells

Activation of NOTCH1 or NOTCH3 Signaling Skews Human Airway Basal Cell Differentiation toward a Secretory Pathway

(2015) Kazunori Gomi et al.   PLoS One

Bioinformatic analysis of ciliary transition zone proteins reveals insights into the evolution of ciliopathy networks

(2014) Amy R Barker et al.   BMC GENOMICS

microRNAs and cilia

(2014) Peter Walentek et al.   CELL CYCLE

Multiciliated Cells

(2014) Eric R. Brooks et al.   CURRENT BIOLOGY

Deep Proteomics of the Xenopus laevis Egg using an mRNA-Derived Reference Database

(2014) Martin Wühr et al.   CURRENT BIOLOGY

A novel serotonin-secreting cell type regulates ciliary motility in the mucociliary epidermis of Xenopus tadpoles

(2014) P. Walentek et al.   DEVELOPMENT

The evolution and conservation of left-right patterning mechanisms

(2014) M. Blum et al.   DEVELOPMENT

A secretory cell type develops alongside multiciliated cells, ionocytes and goblet cells, and provides a protective, anti-infective function in the frog embryonic mucociliary epidermis

(2014) E. Dubaissi et al.   DEVELOPMENT

Lung development: orchestrating the generation and regeneration of a complex organ

(2014) M. Herriges et al.   DEVELOPMENT

Switching on cilia: transcriptional networks regulating ciliogenesis

(2014) S. P. Choksi et al.   DEVELOPMENT

Multicilin drives centriole biogenesis via E2f proteins

(2014) L. Ma et al.   GENES & DEVELOPMENT

miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110

(2014) Rui Song et al.   NATURE

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Xenbase, the Xenopus model organism database; new virtualized system, data types and genomes

(2014) J. Brad Karpinka et al.   NUCLEIC ACIDS RESEARCH

Sp8 regulates inner ear development

(2014) H. A. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myb Permits Multilineage Airway Epithelial Cell Differentiation

(2014) Jie-Hong Pan et al.   STEM CELLS

Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal appendages on the mother centriole during cilia biogenesis

(2014) Shobi Veleri et al.   Nature Communications

Coordinated genomic control of ciliogenesis and cell movement by RFX2

(2014) Mei-I Chung et al.   eLife

A systematic approach identifies FOXA1 as a key factor in the loss of epithelial traits during the epithelial-to-mesenchymal transition in lung cancer

(2013) Haiyun Wang et al.   BMC GENOMICS

miR-34b regulates multiciliogenesis during organ formation in zebrafish

(2013) Lei Wang et al.   DEVELOPMENT

Myb promotes centriole amplification and later steps of the multiciliogenesis program

(2013) F. E. Tan et al.   DEVELOPMENT

Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish

(2013) A. Hruscha et al.   DEVELOPMENT

Biallelic genome modification in F0Xenopus tropicalisembryos using the CRISPR/Cas system

(2013) Ira L. Blitz et al.   GENESIS

Simple and efficient CRISPR/Cas9-mediated targeted mutagenesis inXenopus tropicalis

(2013) Takuya Nakayama et al.   GENESIS

Repair of naphthalene-induced acute tracheal injury by basal cells depends on β-catenin

(2013) Han-Shui Hsu et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality

(2013) Marko T. Boskovski et al.   NATURE

Regulation of Trachebronchial Tissue-Specific Stem Cell Pool Size

(2013) Moumita Ghosh et al.   STEM CELLS

Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells

(2012) M. Morimoto et al.   DEVELOPMENT

Fluid flows and forces in development: functions, features and biophysical principles

(2012) J. B. Freund et al.   DEVELOPMENT

Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation

(2012) J. L. Stubbs et al.   NATURE CELL BIOLOGY

Cigarette Smoking Decreases Global MicroRNA Expression in Human Alveolar Macrophages

(2012) Joel W. Graff et al.   PLoS One

ATP4a Is Required for Wnt-Dependent Foxj1 Expression and Leftward Flow in Xenopus Left-Right Development

(2012) Peter Walentek et al.   Cell Reports

β-Catenin Dosage Is a Critical Determinant of Tracheal Basal Cell Fate Determination

(2011) Heather M. Brechbuhl et al.   AMERICAN JOURNAL OF PATHOLOGY

Notch-Dependent Differentiation of Adult Airway Basal Stem Cells

(2011) Jason R. Rock et al.   Cell Stem Cell

Wnt/ -catenin signaling directly regulates Foxj1 expression and ciliogenesis in zebrafish Kupffer's vesicle

(2011) A. Caron et al.   DEVELOPMENT

Specification of ion transport cells in the Xenopus larval skin

(2011) I. K. Quigley et al.   DEVELOPMENT

RFX2 is broadly required for ciliogenesis during vertebrate development

(2011) Mei-I Chung et al.   DEVELOPMENTAL BIOLOGY

The ciliopathies in neuronal development: a clinical approach to investigation of Joubert syndrome and Joubert syndrome-related disorders

(2011) SHIFTEH SATTAR et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Linking early determinants and cilia-driven leftward flow in left–right axis specification of Xenopus laevis: A theoretical approach

(2011) Axel Schweickert et al.   DIFFERENTIATION

Stages of ciliogenesis and regulation of ciliary length

(2011) Prachee Avasthi et al.   DIFFERENTIATION

Understanding ciliated epithelia: The power ofXenopus

(2011) M.E. Werner et al.   GENESIS

Actin and microtubules drive differential aspects of planar cell polarity in multiciliated cells

(2011) Michael E. Werner et al.   JOURNAL OF CELL BIOLOGY

The three R’s of lung health and disease: repair, remodeling, and regeneration

(2011) Michael F. Beers et al.   JOURNAL OF CLINICAL INVESTIGATION

Erratum: Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway

(2011) Brice Marcet et al.   NATURE CELL BIOLOGY

TP63 P2 promoter functional analysis identifies β-catenin as a key regulator of ΔNp63 expression

(2011) C Ruptier et al.   ONCOGENE

Xenopus pronephros development—past, present, and future

(2011) Oliver Wessely et al.   PEDIATRIC NEPHROLOGY

Ciliopathies: an expanding disease spectrum

(2011) Aoife M. Waters et al.   PEDIATRIC NEPHROLOGY

Xenopus research: metamorphosed by genetics and genomics

(2011) Richard M. Harland et al.   TRENDS IN GENETICS

MicroRNA-449a levels increase by several orders of magnitude during mucociliary differentiation of airway epithelia

(2010) Muriel Lizé et al.   CELL CYCLE

The Nodal Inhibitor Coco Is a Critical Target of Leftward Flow in Xenopus

(2010) Axel Schweickert et al.   CURRENT BIOLOGY

Planar cell polarity signaling, cilia and polarized ciliary beating

(2010) John B Wallingford   CURRENT OPINION IN CELL BIOLOGY

Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling

(2010) J. R. Rock et al.   Disease Models & Mechanisms

Inversin relays Frizzled-8 signals to promote proximal pronephros development

(2010) S. Lienkamp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genome of the Western Clawed Frog Xenopus tropicalis

(2010) U. Hellsten et al.   SCIENCE

Wnt signaling in lung organogenesis

(2010) Stijn P. De Langhe et al.   Organogenesis

The Primary Cilium as a Complex Signaling Center

(2009) Nicolas F. Berbari et al.   CURRENT BIOLOGY

Notch signaling controls the balance of ciliated and secretory cell fates in developing airways

(2009) P.-N. Tsao et al.   DEVELOPMENT

Flow on the right side of the gastrocoel roof plate is dispensable for symmetry breakage in the frog Xenopus laevis

(2009) Philipp Vick et al.   DEVELOPMENTAL BIOLOGY

Xenopus, an ideal model system to study vertebrate left-right asymmetry

(2009) Martin Blum et al.   DEVELOPMENTAL DYNAMICS

In vitro organogenesis from undifferentiated cells inXenopus

(2009) Makoto Asashima et al.   DEVELOPMENTAL DYNAMICS

Basal cells as stem cells of the mouse trachea and human airway epithelium

(2009) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Motile Cilia of Human Airway Epithelia Are Chemosensory

(2009) A. S. Shah et al.   SCIENCE

Cilia orientation and the fluid mechanics of development

(2008) Wallace F Marshall et al.   CURRENT OPINION IN CELL BIOLOGY

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

(2008) E. Dessaud et al.   DEVELOPMENT

Controlling morpholino experiments: don't stop making antisense

(2008) J. S. Eisen et al.   DEVELOPMENT

The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos

(2008) Jennifer L Stubbs et al.   NATURE GENETICS