Epigenetics at the crossroads between genes, environment and resilience in anxiety disorders

CRHR1 promoter hypomethylation: An epigenetic readout of panic disorder?

(2017) Christoph Schartner et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Anxiety among adults with a history of childhood adversity: Psychological resilience moderates the indirect effect of emotion dysregulation

(2017) Julia C. Poole et al.   JOURNAL OF AFFECTIVE DISORDERS

Increased methylation of glucocorticoid receptor gene promoter 1 F in peripheral blood of patients with generalized anxiety disorder

(2017) Wei Wang et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Epigenetic programming by stress and glucocorticoids along the human lifespan

(2017) A S Zannas et al.   MOLECULAR PSYCHIATRY

GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder

(2017) J Deckert et al.   MOLECULAR PSYCHIATRY

Differential Histone Acetylation in Sub-Regions of Bed Nucleus of the Stria Terminalis Underlies Fear Consolidation and Extinction

(2017) Vandana Ranjan et al.   Psychiatry Investigation

Etiology in psychiatry: embracing the reality of poly-gene-environmental causation of mental illness

(2017) Rudolf Uher et al.   World Psychiatry

Does maternal mental well-being in pregnancy impact the early human epigenome?

(2017) Joanne Ryan et al.   Epigenomics

Epigenome-wide association study of DNA methylation in panic disorder

(2017) Mihoko Shimada-Sugimoto et al.   Clinical Epigenetics

The genetics of anxiety-related negative valence system traits

(2016) Jeanne E. Savage et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation

(2016) Rachel Yehuda et al.   BIOLOGICAL PSYCHIATRY

Correlation between the level of microRNA expression in peripheral blood mononuclear cells and symptomatology in patients with generalized anxiety disorder

(2016) Sheng-dong Chen et al.   COMPREHENSIVE PSYCHIATRY

When mothering goes awry: Challenges and opportunities for utilizing evidence across rodent, nonhuman primate and human studies to better define the biological consequences of negative early caregiving

(2016) Stacy S. Drury et al.   HORMONES AND BEHAVIOR

Making Sense of Epigenetics

(2016) Kornel Schuebel et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

ISH NIA OS-01 THE microRNA miR-19a-3p BINDS TO A POLYMORPHISM IN THE GENE FOR THE NORADRENALINE TRANSPORTER AND MAY INCREASE THE RISK OF CARDIOVASCULAR AND PSYCHIATRIC DISEASE

(2016) Francine Marques et al.   JOURNAL OF HYPERTENSION

Influence of 5-HTT variation, childhood trauma and self-efficacy on anxiety traits: a gene-environment-coping interaction study

(2016) Miriam A. Schiele et al.   JOURNAL OF NEURAL TRANSMISSION

The effects of childhood maltreatment on brain structure, function and connectivity

(2016) Martin H. Teicher et al.   NATURE REVIEWS NEUROSCIENCE

MicroRNA’s impact on neurotransmitter and neuropeptide systems: small but mighty mediators of anxiety

(2016) Stefanie Martinetz   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Don't worry; be informed about the epigenetics of anxiety

(2016) Steven J. Nieto et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Neuro-Epigenetic Indications of Acute Stress Response in Humans: The Case of MicroRNA-29c

(2016) Sharon Vaisvaser et al.   PLoS One

Oxytocin receptor DNA methylation in postpartum depression

(2016) Mary Kimmel et al.   PSYCHONEUROENDOCRINOLOGY

Biological markers for anxiety disorders, OCD and PTSD – a consensus statement. Part I: Neuroimaging and genetics

(2016) Borwin Bandelow et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Enhancing dopaminergic signaling and histone acetylation promotes long-term rescue of deficient fear extinction

(2016) N Whittle et al.   Translational Psychiatry

MAOA gene hypomethylation in panic disorder—reversibility of an epigenetic risk pattern by psychotherapy

(2016) C Ziegler et al.   Translational Psychiatry

Methylation of the leukocyte glucocorticoid receptor gene promoter in adults: associations with early adversity and depressive, anxiety and substance-use disorders

(2016) A R Tyrka et al.   Translational Psychiatry

MicroRNA hsa-miR-4717-5p regulates RGS2 and may be a risk factor for anxiety-related traits

(2015) Leif Hommers et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Pediatric-Onset and Adult-Onset Separation Anxiety Disorder Across Countries in the World Mental Health Survey

(2015) Derrick Silove et al.   AMERICAN JOURNAL OF PSYCHIATRY

HPA AXIS RELATED GENES AND RESPONSE TO PSYCHOLOGICAL THERAPIES: GENETICS AND EPIGENETICS

(2015) Susanna Roberts et al.   DEPRESSION AND ANXIETY

Genetic vulnerability, timing of short-term stress and mood regulation: A rodent diffusion tensor imaging study

(2015) Gil Zalsman et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Are there associations between early emotional trauma and anxiety disorders? Evidence from a systematic literature review and meta-analysis

(2015) V. Fernandes et al.   EUROPEAN PSYCHIATRY

Association of human microRNAs miR-22 and miR-491 polymorphisms with panic disorder with or without agoraphobia in a Korean population

(2015) Borah Kim et al.   JOURNAL OF AFFECTIVE DISORDERS

Methylation of NR3C1 and SLC6A4 and internalizing problems. The TRAILS study

(2015) Lisette J. van der Knaap et al.   JOURNAL OF AFFECTIVE DISORDERS

Oxytocin Receptor Gene Methylation: Converging Multilevel Evidence for a Role in Social Anxiety

(2015) Christiane Ziegler et al.   NEUROPSYCHOPHARMACOLOGY

The Genetics of Stress-Related Disorders: PTSD, Depression and Anxiety Disorders

(2015) Jordan W Smoller   NEUROPSYCHOPHARMACOLOGY

Models of Intergenerational and Transgenerational Transmission of Risk for Psychopathology in Mice

(2015) Torsten Klengel et al.   NEUROPSYCHOPHARMACOLOGY

Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health

(2015) Olena Babenko et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes

(2015) Therese M. Murphy et al.   PSYCHIATRIC GENETICS

Early life stress and the anxious brain: evidence for a neural mechanism linking childhood emotional maltreatment to anxiety in adulthood

(2015) G. A. Fonzo et al.   PSYCHOLOGICAL MEDICINE

Attachment style and oxytocin receptor gene variation interact in influencing social anxiety

(2015) S. Notzon et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Circulating microRNA-144-5p is associated with depressive disorders

(2015) Xiao Wang et al.   Clinical Epigenetics

Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disorders

(2015) Magdalene C. Jawahar et al.   Clinical Epigenetics

Stress inoculation modeled in mice

(2015) J Brockhurst et al.   Translational Psychiatry

DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety/depression in older women

(2015) Yvon C. Chagnon et al.   Frontiers in Genetics

The effects of aMAP2K5microRNA target site SNP on risk for anxiety and depressive disorders

(2014) Kevin P. Jensen et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

HDAC inhibitors as cognitive enhancers in fear, anxiety and trauma therapy: where do we stand?

(2014) Nigel Whittle et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Transgenerational Epigenetic Inheritance: Myths and Mechanisms

(2014) Edith Heard et al.   CELL

High social support buffers the effects of 5-HTTLPR genotypes within social anxiety disorder

(2014) Eva Reinelt et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Serotonin transporter gene hypomethylation predicts impaired antidepressant treatment response

(2014) Katharina Domschke et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Heterogeneity and Individuality: microRNAs in Mental Disorders

(2014) Leif G. Hommers et al.   JOURNAL OF NEURAL TRANSMISSION

Pharmacoepigenetics of depression: no major influence of MAO-A DNA methylation on treatment response

(2014) Katharina Domschke et al.   JOURNAL OF NEURAL TRANSMISSION

The Consequences of Early-Life Adversity: Neurobiological, Behavioural and Epigenetic Adaptations

(2014) S. Maccari et al.   JOURNAL OF NEUROENDOCRINOLOGY

Effects of perinatal mental disorders on the fetus and child

(2014) Alan Stein et al.   LANCET

Epigenetic Genes and Emotional Reactivity to Daily Life Events: A Multi-Step Gene-Environment Interaction Study

(2014) Ehsan Pishva et al.   PLoS One

The global burden of anxiety disorders in 2010

(2014) A. J. Baxter et al.   PSYCHOLOGICAL MEDICINE

CRHR1 genotype and history of maltreatment predict cortisol reactivity to stress in adolescents

(2014) Jennifer A. Sumner et al.   PSYCHONEUROENDOCRINOLOGY

Epigenetic mechanisms in fear conditioning: implications for treating post-traumatic stress disorder

(2014) Janine L. Kwapis et al.   TRENDS IN NEUROSCIENCES

An analysis of early developmental trauma in social anxiety disorder and posttraumatic stress disorder

(2014) Melanie Bishop et al.   Annals of General Psychiatry

DNA methylation profiles within the serotonin transporter gene moderate the association of 5-HTTLPR and cortisol stress reactivity

(2014) N Alexander et al.   Translational Psychiatry

Glucocorticoid receptor gene (NR3C1) methylation following stressful events between birth and adolescence. The TRAILS study

(2014) L J van der Knaap et al.   Translational Psychiatry

Serotonin tranporter methylation and response to cognitive behaviour therapy in children with anxiety disorders

(2014) S Roberts et al.   Translational Psychiatry

Resilience in mental health: linking psychological and neurobiological perspectives

(2013) B. P. F. Rutten et al.   ACTA PSYCHIATRICA SCANDINAVICA

Child Abuse and Epigenetic Mechanisms of Disease Risk

(2013) Bao-Zhu Yang et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Cross-talk among epigenetic modifications: lessons from histone arginine methylation

(2013) Diego Molina-Serrano et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cognitive emotion regulation strategies contributing to resilience in patients with depression and/or anxiety disorders

(2013) Jung-Ah Min et al.   COMPREHENSIVE PSYCHIATRY

SEX DIFFERENCES IN DNA METHYLATION MAY CONTRIBUTE TO RISK OF PTSD AND DEPRESSION: A REVIEW OF EXISTING EVIDENCE

(2013) Monica Uddin et al.   DEPRESSION AND ANXIETY

MicroRNAs in the Aging Female Brain: A Putative Mechanism for Age-Specific Estrogen Effects

(2013) Yathindar S. Rao et al.   ENDOCRINOLOGY

Paternal Stress Exposure Alters Sperm MicroRNA Content and Reprograms Offspring HPA Stress Axis Regulation

(2013) A. B. Rodgers et al.   JOURNAL OF NEUROSCIENCE

Parental olfactory experience influences behavior and neural structure in subsequent generations

(2013) Brian G Dias et al.   NATURE NEUROSCIENCE

Lamarck revisited: epigenetic inheritance of ancestral odor fear conditioning

(2013) Moshe Szyf   NATURE NEUROSCIENCE

Serotonergic Genes (5-HTT and HTR1A) and Separation Life Events: Gene-by-Environment Interaction for Panic Disorder

(2013) Ah Young Choe et al.   NEUROPSYCHOBIOLOGY

Methylation of the SLC6a2 Gene Promoter in Major Depression and Panic Disorder

(2013) Richard Bayles et al.   PLoS One

Epigenetic signature of panic disorder: A role of glutamate decarboxylase 1 (GAD1) DNA hypomethylation?

(2013) Katharina Domschke et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Power and Predictive Accuracy of Polygenic Risk Scores

(2013) Frank Dudbridge   PLoS Genetics

Genetics of Anxiety Disorders - Status Quo and Quo Vadis

(2012) Katharina Domschke et al.   CURRENT PHARMACEUTICAL DESIGN

The Role of Life Events and HPA Axis in Anxiety Disorders: A Review

(2012) Carlo Faravelli et al.   CURRENT PHARMACEUTICAL DESIGN

THE IMPACT OF STRESSFUL LIFE EVENTS ON RELAPSE OF GENERALIZED ANXIETY DISORDER

(2012) Jennifer L. Francis et al.   DEPRESSION AND ANXIETY

Evidence that the methylation state of the monoamine oxidase A (MAOA) gene predicts brain activity of MAO A enzyme in healthy men

(2012) Elena Shumay et al.   Epigenetics

Current status and future prospects for epigenetic psychopharmacology

(2012) Marco P. Boks et al.   Epigenetics

Genetic variation inDNMT3Band increased global DNA methylation is associated with suicide attempts in psychiatric patients

(2012) T. M. Murphy et al.   GENES BRAIN AND BEHAVIOR

Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States

(2012) Ronald C. Kessler et al.   INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH

Monoamine oxidase A gene DNA hypomethylation – a risk factor for panic disorder?

(2012) Katharina Domschke et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The Signature of Maternal Rearing in the Methylome in Rhesus Macaque Prefrontal Cortex and T Cells

(2012) N. Provencal et al.   JOURNAL OF NEUROSCIENCE

Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions

(2012) Torsten Klengel et al.   NATURE NEUROSCIENCE

Understanding transgenerational epigenetic inheritance via the gametes in mammals

(2012) Lucia Daxinger et al.   NATURE REVIEWS GENETICS

How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans

(2012) Thomas Frodl et al.   NEUROBIOLOGY OF DISEASE

DNA Methylation and Its Basic Function

(2012) Lisa D Moore et al.   NEUROPSYCHOPHARMACOLOGY

MicroRNAs miR-144/144* and miR-16 in peripheral blood are potential biomarkers for naturalistic stress in healthy Japanese medical students

(2012) Sakurako Katsuura et al.   NEUROSCIENCE LETTERS

Childhood Adversity and Epigenetic Modulation of the Leukocyte Glucocorticoid Receptor: Preliminary Findings in Healthy Adults

(2012) Audrey R. Tyrka et al.   PLoS One

Global prevalence of anxiety disorders: a systematic review and meta-regression

(2012) A. J. Baxter et al.   PSYCHOLOGICAL MEDICINE

Neuropeptide S receptor gene (NPSR) and life events: G × E effects on anxiety sensitivity and its subdimensions

(2012) Benedikt Klauke et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood

(2012) Matthew N Davies et al.   GENOME BIOLOGY

Limbic Scars: Long-Term Consequences of Childhood Maltreatment Revealed by Functional and Structural Magnetic Resonance Imaging

(2011) Udo Dannlowski et al.   BIOLOGICAL PSYCHIATRY

Serotonin transporter gene and childhood trauma - a G × E effect on anxiety sensitivity

(2011) Benedikt Klauke et al.   DEPRESSION AND ANXIETY

Allele-specific methylation in the human genome

(2011) Emma L. Meaburn et al.   Epigenetics

The economic cost of brain disorders in Europe

(2011) J. Olesen et al.   EUROPEAN JOURNAL OF NEUROLOGY

The size and burden of mental disorders and other disorders of the brain in Europe 2010

(2011) H.U. Wittchen et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Stress-Related Methylation of the Catechol-O-Methyltransferase Val158 Allele Predicts Human Prefrontal Cognition and Activity

(2011) G. Ursini et al.   JOURNAL OF NEUROSCIENCE

Gender differences in anxiety disorders: Prevalence, course of illness, comorbidity and burden of illness

(2011) Carmen P. McLean et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Mismatch or cumulative stress: Toward an integrated hypothesis of programming effects

(2011) Esther Nederhof et al.   PHYSIOLOGY & BEHAVIOR

Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 Are Associated with Panic Disorder and Regulate Several Anxiety Candidate Genes and Related Pathways

(2010) Margarita Muiños-Gimeno et al.   BIOLOGICAL PSYCHIATRY

Timing is critical: Gene, environment and timing interactions in genetics of suicide in children and adolescents

(2010) G. Zalsman   EUROPEAN PSYCHIATRY

Advances in molecular genetics of panic disorder

(2010) E Maron et al.   MOLECULAR PSYCHIATRY

TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies

(2010) A Erhardt et al.   MOLECULAR PSYCHIATRY

Examining the unique relationships between anxiety disorders and childhood physical and sexual abuse in the National Comorbidity Survey-Replication

(2010) Jesse R. Cougle et al.   PSYCHIATRY RESEARCH

Effect of childhood physical abuse on cortisol stress response

(2010) Linda L. Carpenter et al.   PSYCHOPHARMACOLOGY

The role of childhood abuse in HPA-axis reactivity in Social Anxiety Disorder: A pilot study

(2009) Bernet M. Elzinga et al.   BIOLOGICAL PSYCHOLOGY

NPYmoderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults

(2009) Ananda B. Amstadter et al.   DEPRESSION AND ANXIETY

Length of Time Between Onset of Childhood Sexual Abuse and Emergence of Depression in a Young Adult Sample

(2009) Martin H. Teicher et al.   JOURNAL OF CLINICAL PSYCHIATRY

DNA Methylation: An Introduction to the Biology and the Disease-Associated Changes of a Promising Biomarker

(2009) Jörg Tost   MOLECULAR BIOTECHNOLOGY

Vulnerability genes or plasticity genes?

(2009) J Belsky et al.   MOLECULAR PSYCHIATRY

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Effects of stress throughout the lifespan on the brain, behaviour and cognition

(2009) Sonia J. Lupien et al.   NATURE REVIEWS NEUROSCIENCE

Psychobiology and molecular genetics of resilience

(2009) Adriana Feder et al.   NATURE REVIEWS NEUROSCIENCE

Imaging genetics of anxiety disorders

(2009) Katharina Domschke et al.   NEUROIMAGE

Beyond diathesis stress: Differential susceptibility to environmental influences.

(2009) Jay Belsky et al.   PSYCHOLOGICAL BULLETIN

Developmental cascades linking stress inoculation, arousal regulation, and resilience

(2009) David Lyons   Frontiers in Behavioral Neuroscience

DNA methylation landscapes: provocative insights from epigenomics

(2008) Miho M. Suzuki et al.   NATURE REVIEWS GENETICS

Stress, sensitive periods and maturational events in adolescent depression

(2008) Susan L. Andersen et al.   TRENDS IN NEUROSCIENCES

Diminished cortisol responses to psychosocial stress associated with lifetime adverse events

(2007) Bernet M. Elzinga et al.   PSYCHONEUROENDOCRINOLOGY