Enhancing dopaminergic signaling and histone acetylation promotes long-term rescue of deficient fear extinction

Activation of D1/5 Dopamine Receptors: A Common Mechanism for Enhancing Extinction of Fear and Reward-Seeking Behaviors

(2016) Antony D Abraham et al.   NEUROPSYCHOPHARMACOLOGY

Efficacy of treatments for anxiety disorders

(2015) Borwin Bandelow et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

Combined Neuropeptide S and D-Cycloserine Augmentation Prevents the Return of Fear in Extinction-Impaired Rodents: Advantage of Dual versus Single Drug Approaches

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Neuronal circuits for fear and anxiety

(2015) Philip Tovote et al.   NATURE REVIEWS NEUROSCIENCE

Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders

(2015) N. Singewald et al.   PHARMACOLOGY & THERAPEUTICS

Fear renewal preferentially activates ventral hippocampal neurons projecting to both amygdala and prefrontal cortex in rats

(2015) Jingji Jin et al.   Scientific Reports

Prefrontal inputs to the amygdala instruct fear extinction memory formation

(2015) O. Bukalo et al.   Science Advances

HDAC inhibitors as cognitive enhancers in fear, anxiety and trauma therapy: where do we stand?

(2014) Nigel Whittle et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mechanisms to medicines: elucidating neural and molecular substrates of fear extinction to identify novel treatments for anxiety disorders

(2014) Olena Bukalo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories

(2014) Johannes Gräff et al.   CELL

Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: A revision of the 2005 guidelines from the British Association for Psychopharmacology

(2014) David S Baldwin et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

(2014) Nitai C Hait et al.   NATURE NEUROSCIENCE

The Potential of HDAC Inhibitors as Cognitive Enhancers

(2013) Johannes Gräff et al.   Annual Review of Pharmacology and Toxicology

EFFECTIVE THERAPIES OR EFFECTIVE MECHANISMS IN TREATMENT GUIDELINES FOR DEPRESSION?

(2013) Pim Cuijpers   DEPRESSION AND ANXIETY

Loss of Histone Deacetylase 2 Improves Working Memory and Accelerates Extinction Learning

(2013) M. J. Morris et al.   JOURNAL OF NEUROSCIENCE

Histone acetylation: molecular mnemonics on the chromatin

(2013) Johannes Gräff et al.   NATURE REVIEWS NEUROSCIENCE

Prefrontal single-unit firing associated with deficient extinction in mice

(2013) Paul J. Fitzgerald et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Synaptic Encoding of Fear Extinction in mPFC-amygdala Circuits

(2013) Jun-Hyeong Cho et al.   NEURON

Single dose of L-dopa makes extinction memories context-independent and prevents the return of fear

(2013) J. Haaker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vorinostat ameliorates impaired fear extinction possibly via the hippocampal NMDA-CaMKII pathway in an animal model of posttraumatic stress disorder

(2013) Yasutaka Matsumoto et al.   PSYCHOPHARMACOLOGY

Increasing Histone Acetylation in the Hippocampus-Infralimbic Network Enhances Fear Extinction

(2012) James M. Stafford et al.   BIOLOGICAL PSYCHIATRY

Vorinostat, a histone deacetylase inhibitor, facilitates fear extinction and enhances expression of the hippocampal NR2B-containing NMDA receptor gene

(2012) Yosuke Fujita et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity

(2012) O Gunduz-Cinar et al.   MOLECULAR PSYCHIATRY

Histone acetylation rescues contextual fear conditioning in nNOS KO mice and accelerates extinction of cued fear conditioning in wild type mice

(2012) Yossef Itzhak et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Deep brain stimulation, histone deacetylase inhibitors and glutamatergic drugs rescue resistance to fear extinction in a genetic mouse model

(2012) Nigel Whittle et al.   NEUROPHARMACOLOGY

Genetic Strain Differences in Learned Fear Inhibition Associated with Variation in Neuroendocrine, Autonomic and Amygdala Dendritic Phenotypes

(2012) Marguerite C Camp et al.   NEUROPSYCHOPHARMACOLOGY

Enhanced Extinction of Aversive Memories by High-Frequency Stimulation of the Rat Infralimbic Cortex

(2012) Mouna Maroun et al.   PLoS One

Lifetime co-morbidity of DSM-IV disorders in the US National Comorbidity Survey Replication Adolescent Supplement (NCS-A)

(2012) R. C. Kessler et al.   PSYCHOLOGICAL MEDICINE

Predicting Treatment Response in Social Anxiety Disorder From Functional Magnetic Resonance Imaging

(2012) Oliver Doehrmann et al.   JAMA Psychiatry

Zinc Deprivation Mediates Alcohol-Induced Hepatocyte IL-8 Analog Expression in Rodents via an Epigenetic Mechanism

(2011) Yantao Zhao et al.   AMERICAN JOURNAL OF PATHOLOGY

S.22.01 Depression and anxiety in Parkinson's disease: under-diagnosed and undertreated

(2011) H. Wittchen et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

Remission from post-traumatic stress disorder in the general population

(2011) C. Chapman et al.   PSYCHOLOGICAL MEDICINE

Infralimbic D2 Receptors Are Necessary for Fear Extinction and Extinction-Related Tone Responses

(2010) Devin Mueller et al.   BIOLOGICAL PSYCHIATRY

Rescue of Impaired Fear Extinction and Normalization of Cortico-Amygdala Circuit Dysfunction in a Genetic Mouse Model by Dietary Zinc Restriction

(2010) N. Whittle et al.   JOURNAL OF NEUROSCIENCE

Dissociable Roles of Prelimbic and Infralimbic Cortices, Ventral Hippocampus and Basolateral Amygdala in the Expression and Extinction of Conditioned Fear

(2010) Demetrio Sierra-Mercado et al.   NEUROPSYCHOPHARMACOLOGY

Plastic Synaptic Networks of the Amygdala for the Acquisition, Expression, and Extinction of Conditioned Fear

(2010) Hans-Christian Pape et al.   PHYSIOLOGICAL REVIEWS

Relapse of Successfully Treated Anxiety and Fear: Theoretical Issues and Recommendations for Clinical Practice

(2009) Mark J. Boschen et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Neurobiological Basis of Failure to Recall Extinction Memory in Posttraumatic Stress Disorder

(2009) Mohammed R. Milad et al.   BIOLOGICAL PSYCHIATRY

Impaired Pavlovian fear extinction is a common phenotype across genetic lineages of the 129 inbred mouse strain

(2009) M. Camp et al.   GENES BRAIN AND BEHAVIOR

Sustained Conditioned Responses in Prelimbic Prefrontal Neurons Are Correlated with Fear Expression and Extinction Failure

(2009) A. Burgos-Robles et al.   JOURNAL OF NEUROSCIENCE

Reciprocal patterns of c-Fos expression in the medial prefrontal cortex and amygdala after extinction and renewal of conditioned fear

(2009) E. Knapska et al.   LEARNING & MEMORY

Transcription Factors in Long-Term Memory and Synaptic Plasticity

(2009) Cristina M. Alberini   PHYSIOLOGICAL REVIEWS

Impaired Fear Extinction Learning and Cortico-Amygdala Circuit Abnormalities in a Common Genetic Mouse Strain

(2008) K. Hefner et al.   JOURNAL OF NEUROSCIENCE

The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear

(2008) T. W. Bredy et al.   LEARNING & MEMORY

Differential roles for hippocampal areas CA1 and CA3 in the contextual encoding and retrieval of extinguished fear

(2008) J. Ji et al.   LEARNING & MEMORY

Switching on and off fear by distinct neuronal circuits

(2008) Cyril Herry et al.   NATURE

Microinfusion of the D1 receptor antagonist, SCH23390 into the IL but not the BLA impairs consolidation of extinction of auditory fear conditioning

(2008) Noam Hikind et al.   NEUROBIOLOGY OF LEARNING AND MEMORY