Dissection of the molecular circuitry controlling virulence in Francisella tularensis

Secreted Effectors Encoded within and outside of the Francisella Pathogenicity Island Promote Intramacrophage Growth

(2016) Aria Eshraghi et al.   Cell Host & Microbe

ppGpp Binding to a Site at the RNAP-DksA Interface Accounts for Its Dramatic Effects on Transcription Initiation during the Stringent Response

(2016) Wilma Ross et al.   MOLECULAR CELL

The magic dance of the alarmones (p)ppGpp

(2016) Wieland Steinchen et al.   MOLECULAR MICROBIOLOGY

Structures of regulatory machinery reveal novel molecular mechanisms controllingB. subtilisnitrogen homeostasis

(2015) Maria A. Schumacher et al.   GENES & DEVELOPMENT

Molecular Mechanism and Evolution of Guanylate Kinase Regulation by (p)ppGpp

(2015) Kuanqing Liu et al.   MOLECULAR CELL

Recent functional insights into the role of (p)ppGpp in bacterial physiology

(2015) Vasili Hauryliuk et al.   NATURE REVIEWS MICROBIOLOGY

Ubiquitous Promoter-Localization of Essential Virulence Regulators in Francisella tularensis

(2015) Kathryn M. Ramsey et al.   PLoS Pathogens

Structural and Biochemical Characterization of the Francisella tularensis Pathogenicity Regulator, Macrophage Locus Protein A (MglA)

(2015) Bonnie J. Cuthbert et al.   PLoS One

A Type VI Secretion-Related Pathway in Bacteroidetes Mediates Interbacterial Antagonism

(2014) Alistair B. Russell et al.   Cell Host & Microbe

Coordinate Control of Virulence Gene Expression in Francisella tularensis Involves Direct Interaction between Key Regulators

(2014) A. E. Rohlfing et al.   JOURNAL OF BACTERIOLOGY

The Francisella tularensis migR,trmE, andcphAGenes Contribute to F. tularensis Pathogenicity Island Gene Regulation and Intracellular Growth by Modulation of the Stress Alarmone ppGpp

(2013) Matthew Faron et al.   INFECTION AND IMMUNITY

The Magic Spot: A ppGpp Binding Site on E. coli RNA Polymerase Responsible for Regulation of Transcription Initiation

(2013) Wilma Ross et al.   MOLECULAR CELL

The Mechanism of E. coli RNA Polymerase Regulation by ppGpp Is Suggested by the Structure of their Complex

(2013) Yuhong Zuo et al.   MOLECULAR CELL

Identification of a Small Molecule That Modifies MglA/SspA Interaction and Impairs Intramacrophage Survival of Francisella tularensis

(2013) Algevis P. Wrench et al.   PLoS One

MglA/SspA Complex Interactions Are Modulated by Inorganic Polyphosphate

(2013) Algevis P. Wrench et al.   PLoS One

SspA up-regulates gene expression of the LEE pathogenicity island by decreasing H-NS levels in enterohemorrhagic Escherichia coli

(2012) Anne-Marie Hansen et al.   BMC MICROBIOLOGY

Direct binding targets of the stringent response alarmone (p)ppGpp

(2012) Usheer Kanjee et al.   MOLECULAR MICROBIOLOGY

Human cytosolic glutathione transferases: structure, function, and drug discovery

(2012) Baojian Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Glutathione transferases: a structural perspective

(2011) Aaron Oakley   DRUG METABOLISM REVIEWS

The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life

(2011) Gemma C. Atkinson et al.   PLoS One

Differential radial capillary action of ligand assay for high-throughput detection of protein-metabolite interactions

(2011) K. G. Roelofs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Francisella Tularensis Virulence

(2011) Shipan Dai et al.   Frontiers in Microbiology

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Role of the Francisella Tularensis Pathogenicity Island in Type VI Secretion, Intracellular Survival, and Modulation of Host Cell Signaling

(2010) Jeanette E. Bröms et al.   Frontiers in Microbiology

The Francisella tularensis pathogenicity island encodes a secretion system that is required for phagosome escape and virulence

(2009) Jeffrey R. Barker et al.   MOLECULAR MICROBIOLOGY

Small Molecule Control of Virulence Gene Expression in Francisella tularensis

(2009) James C. Charity et al.   PLoS Pathogens

(p)ppGpp: Still Magical?

(2008) Katarzyna Potrykus et al.   Annual Review of Microbiology

Identification of fevR, a Novel Regulator of Virulence Gene Expression in Francisella novicida

(2008) A. Brotcke et al.   INFECTION AND IMMUNITY

The global, ppGpp-mediated stringent response to amino acid starvation in Escherichia coli

(2008) Matthew F. Traxler et al.   MOLECULAR MICROBIOLOGY

Advances in bacterial promoter recognition and its control by factors that do not bind DNA

(2008) Shanil P. Haugen et al.   NATURE REVIEWS MICROBIOLOGY