Article
Food Science & Technology
Jingfan Chen, Yuan Yao
Summary: This study investigated the use of phytoglycogen (PG) to enhance the solubility and bioavailability of resveratrol (RES). Solid dispersions of PG-RES were formed through co-solvent mixing and spray-drying. The results showed that the soluble amount of RES in PG-RES solid dispersions reached 289.6 μg/mL, compared to 45.6 μg/mL for RES alone. The tests also indicated a reduction in RES crystallinity and the formation of hydrogen bonds between RES and PG in the solid dispersions. Permeation tests on Caco-2 monolayers demonstrated that PG-RES solid dispersions achieved higher RES permeation at low loading concentrations and showed the potential to enhance the bioavailability of RES.
Article
Biochemistry & Molecular Biology
Benjamin Baylis, Erin Shelton, Michael Grossutti, John R. Dutcher
Summary: Phytoglycogen is a natural glucose polymer produced by sweet corn in the form of compact nanoparticles, which are soft, porous, biodegradable, and non-toxic, making them ideal for applications in personal care, nutrition, and biomedicine. Atomic force microscopy was used to study the morphology and mechanical properties of individual phytoglycogen nanoparticles, revealing their soft, deformable nature and potential for biomedical applications.
Article
Biochemistry & Molecular Biology
Kathleen Charlesworth, Nicholas van Heijst, Aidan Maxwell, Benjamin Baylis, Michael Grossutti, J. Jay Leitch, John R. Dutcher
Summary: In this study, a methodology to functionalize surface plasmon resonance (SPR) sensor surfaces with phytoglycogen (PG) nanoparticles was developed. The utility of the PG-functionalized SPR sensor was demonstrated by measuring the binding affinity of ConA protein to different types of PG nanoparticles. The results showed the potential application of PG as a novel bioactive delivery vehicle.
Article
Chemistry, Multidisciplinary
Dalia A. Ali, Laura Dominguez Mercado, Brandon L. Findlay, Antonella Badia, Christine DeWolf
Summary: Antimicrobial peptide GL13K has high binding selectivity towards bacterial membranes without affecting healthy mammalian cells. However, its delivery is challenging due to susceptibility to proteolytic hydrolysis and poor cellular uptake. This study proposes the use of biodegradable phytoglycogen nanoparticles as protective carriers for GL13K, showing stable colloidal characteristics, efficient loading capacity, and slow release kinetics. The colloidal nanocarrier preserves peptide stability and antimicrobial activity.
Article
Chemistry, Applied
Ye-Rim Lee, Hyun-Mo Jeong, Ji-Soo Kim, Eun-A Kim, Eun-Hyeong Lee, Jae-Hoon Shim
Summary: In order to improve the applicability of quercetin (QCT), we created an inclusion complex of QCT and cyclodextrin glucanotransferase (CGTase; EC 2.4.1.19) called cycloamylose (CA-QCT). The solubility of CA-QCT in water was 55,000 times higher than that of QCT. CA-QCT showed higher stability and antioxidant activity compared to QCT, and it also exhibited greater inhibitory effects on inflammatory mediators.
CARBOHYDRATE POLYMERS
(2023)
Article
Nanoscience & Nanotechnology
Manjiao Zhuang, Lei Rao, Yadi Chen, Shangying Xiao, Haishan Xia, Jiangyong Yang, Xiaohua Lv, Dongyun Qin, Chunjie Zhu
Summary: The study demonstrated a successful development of a quercetin carrier using SPION-modified exosomes, which significantly improved quercetin's water solubility and targeted delivery to pancreatic islets.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Agriculture, Multidisciplinary
Zhenjiong Wang, Yiding Ma, Ying Jiang, Feng Zhou, Yulong Wu, Haitao Jiang, Renlei Wang, Qing Xu, Chun Hua
Summary: Quercetin-loaded gamma-cyclodextrin metal-organic frameworks (Que-CD-MOFs) have significantly enhanced solubility and free radical scavenging ability. Que-CD-MOFs exhibit reduced cytotoxicity to HK-2 cells and maintained inhibition on HT-29 tumor cells, with a preferential location of Que molecules inside the cavities of gamma-cyclodextrin pairs in gamma-CD-MOFs.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Review
Pharmacology & Pharmacy
Seyedeh Roya Alizadeh, Niloofar Savadkouhi, Mohammad Ali Ebrahimzadeh
Summary: Scientists are interested in polyphenols, particularly flavonoids, such as quercetin, due to their various therapeutic properties. However, quercetin's bioavailability is often low. This review discusses strategies for improving water solubility and bioavailability of quercetin, including structural modifications and drug delivery systems.
EXPERT OPINION ON DRUG DISCOVERY
(2023)
Article
Pharmacology & Pharmacy
Mohamed Y. Y. Zakaria, Shady M. M. Abd El-Halim, Botros Y. Y. Beshay, Islam Zaki, Mohammed A. S. Abourehab
Summary: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to a global catastrophe, prompting the development of a safe and effective therapeutic system. Polyphenols such as resveratrol (RSV) have proven antiviral activity. However, RSV suffers from limited solubility and degradation in the gastrointestinal tract and liver, hindering its clinical use. PEGylated bilosomes (PBs) containing a PEGylated edge activator were proposed to enhance the permeability and bioavailability of RSV. The optimized formula (F5) showed improved dissolution behavior, increased cellular uptake, and complete in vitro suppression of SARS-CoV-2, suggesting it as a promising oral treatment for SARS-CoV-2 infection.
Article
Chemistry, Multidisciplinary
Paula Ossowicz-Rupniewska, Kaja Szczepkowska, Paulina Bednarczyk, Malgorzata Nowak, Anna Nowak, Wiktoria Duchnik, Lukasz Kucharski, Lukasz Struk, Adam Klimowicz, Zbigniew Czech
Summary: This study evaluated the effect of introducing structural modification of ibuprofen on its skin permeability and the properties of the adhesive layer of medical patches. It showed that acrylic-based patches can deliver a therapeutically appropriate dose of ibuprofen.
Article
Pharmacology & Pharmacy
Dong Ye, Alvaro Lopez Marmol, Verena Lenz, Patricia Muschong, Anita Wilhelm-Alkubaisi, Manuel Weinheimer, Mirko Koziolek, Kerstin A. Sauer, Loic Laplanche, Mario Mezler
Summary: The mucin-protected Caco-2 assay combined with biorelevant media improves the mechanistic understanding of drug permeation and addresses complex biopharmaceutical questions, such as food effects on oral drug absorption.
Article
Chemistry, Applied
Weeranuch Lang, Yuya Kumagai, Shinji Habu, Juri Sadahiro, Takayoshi Tagami, Masayuki Okuyama, Shinichi Kitamura, Nobuo Sakairi, Atsuo Kimura
Summary: The study showed that Isomaltomegalosaccharide (IMS) has bifunctionality, enhancing water solubility while also displaying some hydrophobicity. IMS can increase the solubility of less-soluble bioactive substances, which is beneficial in the carbohydrate industry.
CARBOHYDRATE POLYMERS
(2022)
Article
Food Science & Technology
Kevser Kandemir, Merve Tomas, David Julian McClements, Esra Capanoglu
Summary: This review summarizes the major factors affecting the bioavailability of quercetin, as well as approaches being developed to increase its bioavailability. Food matrix and encapsulation technology are key factors in improving the bioavailability of quercetin.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zufika Qamar, Muhammad Usama Ashhar, Annu, Farheen Fatima Qizilibash, Pravat Kumar Sahoo, Asgar Ali, Javed Ali, Sanjula Baboota
Summary: In this study, a lipid nanocarrier formulation containing SEL and a P-gp pump inhibitor Quercetin (SEL-QUR LNC) was developed to enhance the bioavailability of SEL in the brain through oral administration. The optimized formulation showed improved properties and increased permeation across the gut membrane, demonstrating potential for enhancing SEL efficacy. Behavioral studies in PD rats further supported the efficacy of the formulation compared to SEL-QUR and SEL suspensions, indicating the promising prospect of the developed LNC formulation for improving SEL bioavailability in the brain.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Food Science & Technology
Yufeng Chen, Guobin Xia, Chunfeng Wang, Huawei Wu, Xiaogang Xu, Genxiang Mao, Jiong Wu, Zhenlei Zhao
Summary: 7,8-DHF is a biologically active flavone with various physiological activities. Previous studies have found that the efflux protein P-glycoprotein (P-gp) significantly affects the oral bioavailability of 7,8-DHF. In this study, 14 dietary plant flavonoids were investigated as potential P-gp inhibitors using a Caco-2 cell model, and their effects on the transepithelial transport and in vitro digestion of 7,8-DHF were explored. The results showed that certain flavonoids, especially kaempferol and quercetin, improved the transepithelial transport of 7,8-DHF, thereby enhancing its oral bioavailability.
FOOD SCIENCE & NUTRITION
(2023)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.