Hypothesis - buttressed rings assemble, clamp, and release SNAREpins for synaptic transmission

The primed SNARE–complexin–synaptotagmin complex for neuronal exocytosis

(2017) Qiangjun Zhou et al.   NATURE

Synaptotagmin-7-Mediated Asynchronous Release Boosts High-Fidelity Synchronous Transmission at a Central Synapse

(2017) Fujun Luo et al.   NEURON

Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18

(2017) Ying Lai et al.   NEURON

Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release

(2017) Rashmi Voleti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low energy cost for optimal speed and control of membrane fusion

(2017) Claire François-Martin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Morphologies of synaptic protein membrane fusion interfaces

(2017) Preeti Gipson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circular oligomerization is an intrinsic property of synaptotagmin

(2017) Jing Wang et al.   eLife

Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN

(2017) Junjie Xu et al.   eLife

A Stimulation Function of Synaptotagmin-1 in Ternary SNARE Complex Formation Dependent on Munc18 and Munc13

(2017) Yun Li et al.   Frontiers in Molecular Neuroscience

Calculating Transition Energy Barriers and Characterizing Activation States for Steps of Fusion

(2016) Rolf J. Ryham et al.   BIOPHYSICAL JOURNAL

A Programmable DNA Origami Platform to Organize SNAREs for Membrane Fusion

(2016) Weiming Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chaperoning SNARE assembly and disassembly

(2016) Richard W. Baker et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Kinetic barriers to SNAREpin assembly in the regulation of membrane docking/priming and fusion

(2016) Feng Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanodisc-cell fusion: control of fusion pore nucleation and lifetimes by SNARE protein transmembrane domains

(2016) Zhenyong Wu et al.   Scientific Reports

Ring-like oligomers of Synaptotagmins and related C2 domain proteins

(2016) Maria N Zanetti et al.   eLife

PtdInsP2 and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium

(2016) Ángel Pérez-Lara et al.   eLife

FRAP to Characterize Molecular Diffusion and Interaction in Various Membrane Environments

(2016) Frédéric Pincet et al.   PLoS One

Membrane tension and membrane fusion

(2015) Michael M Kozlov et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Architecture of the synaptotagmin–SNARE machinery for neuronal exocytosis

(2015) Qiangjun Zhou et al.   NATURE

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming

(2015) Xiaoyu Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming

(2015) Xiaoyu Yang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Architecture of the Synaptophysin/Synaptobrevin Complex: Structural Evidence for an Entropic Clustering Function at the Synapse

(2015) Daniel J. Adams et al.   Scientific Reports

The Principle of Membrane Fusion in the Cell (Nobel Lecture)

(2014) James Edward Rothman   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Molecular Machinery of Neurotransmitter Release (Nobel Lecture)

(2014) Thomas C. Südhof   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Calcium sensitive ring-like oligomers formed by synaptotagmin

(2014) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane curvature sensing by the C-terminal domain of complexin

(2014) David Snead et al.   Nature Communications

Common intermediates and kinetics, but different energetics, in the assembly of SNARE proteins

(2014) Sylvain Zorman et al.   eLife

Molecular Mechanisms for Synchronous, Asynchronous, and Spontaneous Neurotransmitter Release

(2013) Pascal S. Kaeser et al.   Annual Review of Physiology

Computer simulations of lipid membrane domains

(2013) W.F. Drew Bennett et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Conical Lipids in Flat Bilayers Induce Packing Defects Similar to that Induced by Positive Curvature

(2013) Lydie Vamparys et al.   BIOPHYSICAL JOURNAL

Cryo–electron tomography reveals a critical role of RIM1α in synaptic vesicle tethering

(2013) Rubén Fernández-Busnadiego et al.   JOURNAL OF CELL BIOLOGY

CAPS and Munc13 utilize distinct PIP2-linked mechanisms to promote vesicle exocytosis

(2013) Greg Kabachinski et al.   MOLECULAR BIOLOGY OF THE CELL

Differential triggering of spontaneous glutamate release by P/Q-, N- and R-type Ca2+ channels

(2013) Yaroslav S Ermolyuk et al.   NATURE NEUROSCIENCE

Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment

(2013) Alf Honigmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synaptotagmin-1 and Synaptotagmin-7 Trigger Synchronous and Asynchronous Phases of Neurotransmitter Release

(2013) Taulant Bacaj et al.   NEURON

Synaptic Vesicles Position Complexin to Block Spontaneous Fusion

(2013) Rachel T. Wragg et al.   NEURON

Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle

(2013) Thomas C. Südhof   NEURON

SNAREpin Assembly by Munc18-1 Requires Previous Vesicle Docking by Synaptotagmin 1

(2012) Daniel Parisotto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C-Terminal Complexin Sequence Is Selectively Required for Clamping and Priming But Not for Ca2+ Triggering of Synaptic Exocytosis

(2012) Y. J. Kaeser-Woo et al.   JOURNAL OF NEUROSCIENCE

The Presynaptic Active Zone

(2012) Thomas C. Südhof   NEURON

Reconstitution of the Vital Functions of Munc18 and Munc13 in Neurotransmitter Release

(2012) C. Ma et al.   SCIENCE

SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open

(2012) L. Shi et al.   SCIENCE

Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages

(2012) Y. Gao et al.   SCIENCE

Perspectives on Kiss-and-Run: Role in Exocytosis, Endocytosis, and Neurotransmission

(2011) AbdulRasheed A. Alabi et al.   Annual Review of Physiology

Membrane protein sequestering by ionic protein–lipid interactions

(2011) Geert van den Bogaart et al.   NATURE

Complexin cross-links prefusion SNAREs into a zigzag array

(2011) Daniel Kümmel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state

(2011) Feng Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RIM Proteins Activate Vesicle Priming by Reversing Autoinhibitory Homodimerization of Munc13

(2011) Lunbin Deng et al.   NEURON

The Crystal Structure of a Munc13 C-terminal Module Exhibits a Remarkable Similarity to Vesicle Tethering Factors

(2011) Wei Li et al.   STRUCTURE

Insights into the molecular organization of the neuron by cryo-electron tomography

(2011) R. Fernandez-Busnadiego et al.   Microscopy

Quantitative analysis of the native presynaptic cytomatrix by cryoelectron tomography

(2010) Rubén Fernández-Busnadiego et al.   JOURNAL OF CELL BIOLOGY

Synaptobrevin N-terminally bound to syntaxin–SNAP-25 defines the primed vesicle state in regulated exocytosis

(2010) Alexander M. Walter et al.   JOURNAL OF CELL BIOLOGY

Solvent-Exposed Tails as Prestalk Transition States for Membrane Fusion at Low Hydration

(2010) Yuliya G. Smirnova et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

One SNARE complex is sufficient for membrane fusion

(2010) Geert van den Bogaart et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Quantification of phase transitions of lipid mixtures from bilayer to non-bilayer structures: Model, experimental validation and implication on membrane fusion

(2009) Weiming Xu et al.   CHEMISTRY AND PHYSICS OF LIPIDS

The ins and outs of phospholipid asymmetry in the plasma membrane: roles in health and disease

(2009) Bengt Fadeel et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

A role of complexin-lipid interactions in membrane fusion

(2009) Florian Seiler et al.   FEBS LETTERS

Pulling force generated by interacting SNAREs facilitates membrane hemifusion

(2009) Midhat H. Abdulreda et al.   Integrative Biology

Remote Homology between Munc13 MUN Domain and Vesicle Tethering Complexes

(2009) Jimin Pei et al.   JOURNAL OF MOLECULAR BIOLOGY

Dynamic structure of lipid-bound synaptobrevin suggests a nucleation-propagation mechanism for trans-SNARE complex formation

(2009) J. F. Ellena et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative Zippering as an On-Off Switch for SNARE-Mediated Fusion

(2009) C. G. Giraudo et al.   SCIENCE

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

Lipids on the move: Simulations of membrane pores, domains, stalks and curves

(2008) Siewert J. Marrink et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Regulation of phospholipid asymmetry in the erythrocyte membrane

(2008) David L Daleke   CURRENT OPINION IN HEMATOLOGY

Spontaneous and Evoked Glutamate Release Activates Two Populations of NMDA Receptors with Limited Overlap

(2008) D. Atasoy et al.   JOURNAL OF NEUROSCIENCE

The SNAP-25 Linker as an Adaptation Toward Fast Exocytosis

(2008) Gábor Nagy et al.   MOLECULAR BIOLOGY OF THE CELL