Review
Neurosciences
Takashi Namba, Jeannette Nardelli, Pierre Gressens, Wieland B. Huttner
Summary: The neocortex has expanded in certain mammals such as primates, including humans, and NPC metabolism is now recognized as a major regulator of NPC proliferation in neocortical development. Insights into the role of NPC metabolism in neurodevelopmental disorders and its relevance for neocortex evolution have been summarized, highlighting the impact of metabolism on NPC proliferation and neocortical development.
Review
Biochemistry & Molecular Biology
Kseniia Sarieva, Simone Mayer
Summary: The translation provides an overview of how prenatal environmental adversity impacts human brain development and the use of brain organoids to study these effects. It also highlights the challenges in the field, such as protocol variability and a lack of benchmarking for cross-study comparisons.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Developmental Biology
Jisoo S. Han, Elizabeth Fishman-Williams, Steven C. Decker, Keiko Hino, Raenier V. Reyes, Nadean L. Brown, Sergi Simo, Anna La Torre
Summary: The central nervous system is composed of different types of cells derived from multipotent neural progenitors. Spatial position and temporal cues play important roles in determining the fate of neural progenitors and generating various cell populations. Notch signaling pathway has been found to be crucial in this process, particularly in the development of neocortex and hippocampus, as well as the corpus callosum and choroid plexus. Notch signaling controls the fate determination of projection neurons in the neocortex through the regulation of two microRNA clusters, including let-7, miR-99a/100, and miR-125b. The interplay between Notch and miRNAs is essential for the regulation of neocortical progenitor behaviors and neuron cell fate decisions.
Review
Cell Biology
Belal Shohayeb, Zukhrofi Muzar, Helen M. Cooper
Summary: This review discusses the fundamental molecular and cellular mechanisms regulating neural progenitor function and neuronal diversity generation, as well as the essential structural features of cortical neurons' origin, proliferation, and differentiation. Furthermore, researchers have also explored how individual neuronal identity emerges as a result of exposure to temporally regulated extrinsic cues.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Ayano Kawaguchi
Summary: During neocortical development, the delamination of neurogenic cells is crucial for their migration, with the proper timing of detachment of the apical endfeet being critical for neurogenesis. Various molecular mechanisms, including the regulation of cell adhesion and cytoskeletal architecture, contribute to neurogenic cell delamination and potentially the generation of other types of neural progenitor cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Neurosciences
Yuki Bando, Masaru Ishibashi, Satoru Yamagishi, Atsuo Fukuda, Kohji Sato
Summary: This review summarizes the functions of ion channels and transporters in neocortical development and discusses the links between channelopathies and neocortical development. Furthermore, it introduces emerging optical techniques for studying neocortical development and the pathophysiology of channelopathies.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Clinical Neurology
Vasiliki Gkini, Takashi Namba
Summary: Multiple types of neural progenitor cells contribute to the development of the neocortex, and their metabolisms, especially glutaminolysis, play a critical role in neocortical development, evolution, and neurodevelopmental disorders.
Article
Oncology
Bedika Pathak, Taylor E. Lange, Kristin Lampe, Ella Hollander, Marina Oria, Kendall P. Murphy, Nathan Salomonis, Mathieu Sertorio, Marc Oria
Summary: Exposure to radiation can lead to central nervous system toxicity, especially for neural progenitor cells (NPCs). However, the mechanisms of radiation-induced CNS toxicity are not fully understood. This study developed a 3D neurosphere culture system using rat NPCs to evaluate the effects of experimental drugs and radiation on NPC growth and differentiation. The findings suggest that radiation inhibits NPC growth, decreases proliferation, and induces astrocytic differentiation. This culture system provides a preclinical model for studying radiation modalities and potential therapeutic interventions.
Article
Multidisciplinary Sciences
Martin W. Breuss, Xiaoxu Yang, Johannes C. M. Schlachetzki, Danny Antaki, Addison J. Lana, Xin Xu, Changuk Chung, Guoliang Chai, Valentina Stanley, Qiong Song, Traci F. Newmeyer, An Nguyen, Sydney O'Brien, Marten A. Hoeksema, Beibei Cao, Alexi Nott, Jennifer McEvoy-Venneri, Martina P. Pasillas, Scott T. Barton, Brett R. Copeland, Shareef Nahas, Lucitia Van der Kraan, Yan Ding, Christopher K. Glass, Joseph G. Gleeson
Summary: The structure of the human neocortex and its developmental processes were investigated through the assessment of brain somatic mosaicism. Samples from adult human tissues were analyzed, revealing distinct geographical, cell-type, and Glade organizations in the brain and other organs. The findings suggest that the clones in the cerebral cortex respect the midline axis and have dual origins from both dorsal and ventral cellular populations.
Article
Multidisciplinary Sciences
Matthew T. Schmitz, Kadellyn Sandoval, Christopher P. Chen, Mohammed A. Mostajo-Radji, William W. Seeley, Tomasz J. Nowakowski, Chun Jimmie Ye, Mercedes F. Paredes, Alex A. Pollen
Summary: This study investigates the gene expression trajectories of inhibitory neurons (INs) in primates and mice during neurogenic period. Researchers find that while the initial classes of INs generated prenatally are largely conserved among mammals, there are contrasting developmental mechanisms for specifying evolutionarily novel cell types during prenatal development.
Article
Multidisciplinary Sciences
Lu Wang, Caleb Heffner, Keng Loi Vong, Chelsea Barrows, Yoo-Jin Ha, Sangmoon Lee, Pablo Lara-Gonzaleze, Ishani Jhamb, Dennis Van der Meer, Robert Loughnan, Nadine Parker, David Sievert, Swapnil Mittal, Mahmoud Y. Issa, Ole A. Andreassen, Anders Dale, William B. Dobyns, Maha S. Zaki, Stephen A. Murray, Joseph G. Gleeson
Summary: TMEM161B is a widely expressed transmembrane protein of unknown function in human, and mutations in this gene cause recessive polymicrogyria (PMG) and intellectual disability. Studies in mice and patient-derived brain organoids show that TMEM161B is involved in the development of the neocortex through regulation of apical cell polarity and radial glial scaffolding. TMEM161B modulates actin filopodia, acting upstream of the Rho-GTPase CDC42. These findings link TMEM161B to human PMG and provide insights into the role of TMEM161B in neocortical development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Jiafeng Zhou, Gaoao Liu, Xiaoling Zhang, Chao Wu, Mengjie Ma, Jiarui Wu, Lin Hou, Bin Yin, Boqin Qiang, Pengcheng Shu, Xiaozhong Peng
Summary: This study compared the activity patterns of Emx1(IRES)-Cre, D6-Cre, and hGFAP-Cre in the early embryos and found that their differences in activity can lead to divergent phenotypes, providing valuable insight for researchers in experimental design.
Article
Cell Biology
Jinyue Zhao, Chao Feng, Wenwen Wang, Libo Su, Jianwei Jiao
Summary: Neocortex expansion and folding are linked to human intelligence and cognition. The study discovered that the overexpression of the SERPINA3 gene can induce neocortical folding, increase neuron abundance, and improve cognitive abilities. Further investigation revealed that SERPINA3 promotes the proliferation of outer radial glia and affects cortical folding.
Article
Multidisciplinary Sciences
Elia Magrinelli, Natalia Baumann, Robin Jan Wagener, Christelle Glangetas, Camilla Bellone, Denis Jabaudon, Esther Klingler
Summary: Neocortical excitatory neurons exhibit diverse cell types during development, and their fate is regulated by various factors. The study reveals that early neurons have heterogeneous fates, while later-born simultaneously-born neurons have more homogeneous fates. Single-cell gene expression analysis shows that early-born neurons exhibit molecular heterogeneity and initiate late-born neuron transcriptional programs.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Victoria N. Neckles, David M. Feliciano
Summary: Physiological functions require coordination among diverse organs, tissues, and cells. Microglia, immune cells in the brain, play a critical role in both defense against harmful pathogens and cellular debris as well as in neurophysiology.
CELL AND TISSUE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Esther Klingler, Andres De la Rossa, Sabine Fievre, Karthikeyan Devaraju, Philipp Abe, Denis Jabaudon
Article
Multidisciplinary Sciences
L. Telley, G. Agirman, J. Prados, N. Amberg, S. Fievre, P. Oberst, G. Bartolini, I. Vitali, C. Cadilhac, S. Hippenmeyer, L. Nguyen, A. Dayer, D. Jabaudon
Article
Multidisciplinary Sciences
Polina Oberst, Sabine Fievre, Natalia Baumann, Cristina Concetti, Giorgia Bartolini, Denis Jabaudon
Editorial Material
Biology
Esther Klingler, Denis Jabaudon
Review
Multidisciplinary Sciences
Esther Klingler, Fiona Francis, Denis Jabaudon, Silvia Cappello
Summary: This article discusses the composition of the cerebral cortex, the causes of neurodevelopmental disorders, and the importance of a multilevel assessment of disease processes for developing therapeutic strategies.
Article
Cell Biology
Greta Limoni, Sahana Murthy, Denis Jabaudon, Alexandre Dayer, Mathieu Niquille
Summary: Deep-layer inhibitory interneurons (INs) in the mammalian cerebral cortex control the laminar allocation of 5-HT receptor 3a-expressing (HTR3A(+)) cortical INs (hlNs) by secreting Semaphorin3A (SEMA3A).
Article
Neurosciences
Suranjana Pal, Deepanjali Dwivedi, Tuli Pramanik, Geeta Godbole, Takuji Iwasato, Denis Jabaudon, Upinder S. Bhalla, Shubha Tole
Summary: Loss of the LHX2 gene in cortical progenitors results in premature ingrowth of thalamocortical afferents into the cortex, leading to atrophy of the sensory thalamus and nearly eliminating sensory innervation to the cortex. This indicates a profound mechanism operating in subplate progenitors affecting the growth of thalamocortical axons into the cortex.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Stamatina Tzanoulinou, Stefano Musardo, Alessandro Contestabile, Sebastiano Bariselli, Giulia Casarotto, Elia Magrinelli, Yong-hui Jiang, Denis Jabaudon, Camilla Bellone
Summary: Mutations in the SHANK3 gene have been identified as a genetic risk factor for Autism Spectrum Disorder (ASD). This study demonstrates that region-specific downregulation of Shank3 in neonatal mice leads to hyperexcitability of certain neurons and impairs social behavior. Furthermore, acute inhibition of Trpv4 can rescue these behavioral deficits.
MOLECULAR PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Esther Klingler, Ugo Tomasello, Julien Prados, Justus M. Kebschull, Alessandro Contestabile, Gregorio L. Galinanes, Sabine Fievre, Antonio Santinha, Randal Platt, Daniel Huber, Alexandre Dayer, Camilla Bellone, Denis Jabaudon
Summary: Interconnectivity between neocortical areas is essential for sensory integration and sensorimotor transformations, mediated by heterogeneous inter-areal cortical projection neurons (ICPN) that are anatomically diverse but molecularly homogeneous. The study revealed distinct molecular and functional differentiation paces of different subtypes of ICPN within a single cortical area, impacting circuit connectivities and functions. Dynamic differences in gene expression levels may account for the emergence of intra-type diversity in cortical neurons.
News Item
Multidisciplinary Sciences
Sergi Roig Puiggros, Denis Jabaudon
Summary: The visual experience of mouse pups when they first open their eyes shapes neuronal connectivity, but it specifically acts on a subset of malleable neurons.
Article
Cell Biology
Ugo Tomasello, Esther Klingler, Mathieu Niquille, Nandkishor Mule, Antonio J. Santinha, Laura de Vevey, Julien Prados, Randall J. Platt, Victor Borrell, Denis Jabaudon, Alexandre Dayer
Summary: This study reveals the regulatory role of the outer subventricular zone (oSVZ) and two microRNAs (miR-137 and miR-122) in cortical expansion, enhancing our understanding of cortical development and evolution.
Article
Multidisciplinary Sciences
Elia Magrinelli, Natalia Baumann, Robin Jan Wagener, Christelle Glangetas, Camilla Bellone, Denis Jabaudon, Esther Klingler
Summary: Neocortical excitatory neurons exhibit diverse cell types during development, and their fate is regulated by various factors. The study reveals that early neurons have heterogeneous fates, while later-born simultaneously-born neurons have more homogeneous fates. Single-cell gene expression analysis shows that early-born neurons exhibit molecular heterogeneity and initiate late-born neuron transcriptional programs.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Katrin Gerstmann, Karine Kindbeiter, Ludovic Telley, Muriel Bozon, Florie Reynaud, Emy Theoulle, Camille Charoy, Denis Jabaudon, Frederic Moret, Valerie Castellani
Summary: During corticogenesis, diffusible signals from the cerebrospinal fluid may contribute to the dynamic regulation of apical adhesion, resulting in dual effects on cell positioning and cell progeny.
Article
Multidisciplinary Sciences
Guillaume Marcy, Louis Foucault, Elodie Babina, Timothy Capeliez, Emeric Texeraud, Stefan Zweifel, Christophe Heinrich, Hector Hernandez-Vargas, Carlos Parras, Denis Jabaudon, Olivier Raineteau
Summary: By performing single-cell RNA sequencing of the ventricular-subventricular zone, researchers found that neural stem cells enter a state of deep quiescence and suppress the production and differentiation of glutamatergic neurons, leading to rapid silencing of pallial germinal activity.
Article
Multidisciplinary Sciences
Fabrizia Pipicelli, Natalia Baumann, Rossella Di Giaimo, Andrea Forero-Echeverry, Christina Kyrousi, Rebecca Bonrath, Giuseppina Maccarrone, Denis Jabaudon, Silvia Cappello
Summary: Disruption in neurogenesis and neuronal migration can disrupt cortical circuit assembly and lead to neurodevelopmental and neuropsychiatric disorders. Extracellular vesicles released in the external environment were found to regulate neuronal molecular differentiation and alter migratory dynamics. These findings suggest that extracellular vesicles may play a role in modulating neuronal development.
