Article
Neurosciences
Inmaculada Crespo, Jaime Pignatelli, Veena Kinare, Hector R. Mendez-Gomez, Miriam Esgleas, Maria Jose Roman, Josep M. Canals, Shubha Tole, Carlos Vicario
Summary: This study investigates the impact of misexpression of the Tbr1 transcription factor on mouse neural progenitor cells. The results suggest that Tbr1 misexpression delays or disrupts neuronal migration, specification, and dendrite development, potentially leading to brain malformations.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Ping Dong, Yang Zhang, Arsen S. Hunanyan, Mohamad A. Mikati, Jianmin Cui, Huanghe Yang
Summary: An increasing number of gain-of-function BK channelopathies have been found to be associated with motor deficits and dyskinesia-like behaviors. Our study reveals the neuronal mechanism of BK gain-of-function in absence epilepsy and dyskinesia, and suggests that BK inhibition is a promising therapeutic strategy for BK gain-of-function-induced neurological disorders.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Shutaro Katsurabayashi, Kohei Oyabu, Kaori Kubota, Takuya Watanabe, Tomohisa Nagamatsu, Norio Akaike, Katsunori Iwasaki
Summary: The study found that TND1128 can promote morphological growth of mouse hippocampal neurons, increase the number of excitatory synapses, and provide a new drug treatment approach for improving brain function.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Developmental Biology
Pankajam Thyagarajan, Chengye Feng, David Lee, Matthew Shorey, Melissa M. Rolls
Summary: Microtubule polarity plays a crucial role in neuronal polarization by influencing other cytoskeletal features, although changes in microtubule polarity have minimal effects on overall neuron shape.
DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Jacqueline M. Ehrman, Paloma Merchan-Sala, Lisa A. Ehrman, Bin Chen, Hee-Woong Lim, Ronald R. Waclaw, Kenneth Campbell
Summary: The projection neurons of the striatum can be categorized into the striatopallidal (indirect) pathway or the striatonigral (direct) pathway. Striatonigral axons pioneer the internal capsule and cerebral peduncle and provide guidance for corticofugal and thalamocortical axons. Defects in the striatonigral pathway can disrupt internal capsule formation.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Yuki Yamazaki, Maho Moizumi, Jun Nagai, Yoshiki Hatashita, Tianhong Cai, Papachan Kolattukudy, Takafumi Inoue, Yoshio Goshima, Toshio Ohshima
Summary: This study demonstrated the importance of Cdk5-mediated phosphorylation of CRMP2 in neuronal migration in the developing cerebral cortex, with redundant functions of CRMP1 and CRMP4. Experimental results showed that these three proteins play crucial roles in proper neuronal migration.
Article
Neurosciences
Kumari Vandana Singh, Chandra Prakash, Jay Prakash Nirala, Ranjan Kumar Nanda, Paulraj Rajamani
Summary: Mobile phones are commonly used devices for digital media and communication, but their radiofrequency electromagnetic radiation (RF-EMR) can have adverse effects on the brains of young adolescents. This study found that exposure to RF-EMR led to lipid peroxidation, DNA damage, and reduced neurogenesis and neuronal degeneration in the brain of rats.
Article
Biology
Shufeng Bu, Samuel Song Yuan Lau, Wei Lin Yong, Heng Zhang, Sasinthiran Thiagarajan, Arash Bashirullah, Fengwei Yu
Summary: The study reveals the important roles of PcG and Hox genes in regulating ecdysone signalling and neuronal pruning in Drosophila. The findings suggest a non-canonical and PRC2-independent role of PRC1 in Hox gene silencing during neuronal pruning.
Article
Neurosciences
Ji-Wei Liu, Han Li, Yang Zhang
Summary: This study investigates the role of the neuronal gene Npas3 in cortical development in mice. The knockdown of Npas3 impairs neuronal radial migration and alters cell fate in deep cortical layers. Additionally, the downregulation of Npas3 maintains the stemness of radial glial cells and increases the proliferation rate of neural progenitor cells.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Ilkka Fagerlund, Antonios Dougalis, Anastasia Shakirzyanova, Mireia Gomez-Budia, Anssi Pelkonen, Henna Konttinen, Sohvi Ohtonen, Mohammad Feroze Fazaludeen, Marja Koskuvi, Johanna Kuusisto, Damian Hernandez, Alice Pebay, Jari Koistinaho, Tuomas Rauramaa, Sarka Lehtonen, Paula Korhonen, Tarja Malm
Summary: Human cerebral organoids derived from induced pluripotent stem cells can mimic the development of the cerebral cortex. By transplanting erythromyeloid progenitors differentiated from induced pluripotent stem cells, microglia-like cells can be formed in the organoids, promoting neuronal and network maturation through interaction with synaptic material.
Review
Neurosciences
Tomonori Furukawa, Atsuo Fukuda
Summary: During brain and spinal cord development, the inhibitory neurotransmitters GABA and glycine cause depolarization instead of hyperpolarization in adults. This is influenced by changes in the transmembrane chloride gradient, which is regulated by chloride transporters. The endogenous agonists for these receptors are not fully understood, but taurine is suggested to play a role in the development of neocortex by tonically activating GABA(A)Rs and modulating glycine receptors. Taurine also regulates chloride homeostasis through the WNK-SPAK/OSR1 signaling pathway.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Neurosciences
Csaba Cserep, Balazs Posfai, Adam Denes
Summary: Microglia establishing direct contact with neurons play a crucial role in regulating neuronal responses and fate, contributing significantly to brain diseases.
Article
Cell Biology
Xiao Liu, Shang-Kun Dai, Pei-Pei Liu, Chang-Mei Liu
Summary: This study demonstrates the important role of Arid1a in regulating the proliferation and differentiation of neural stem/progenitor cells during cortical development, and suggests potential gene candidates for understanding the pathological mechanisms and developing interventions for neurodevelopmental disorders caused by Arid1a mutations. Rescue experiments successfully restored the neurogenic defects in Arid1a knockout neural stem/progenitor cells.
CELL PROLIFERATION
(2021)
Article
Multidisciplinary Sciences
Denise E. Allen, Kevin C. Donohue, Cathryn R. Cadwell, David Shin, Matthew G. Keefe, Vikaas S. Sohal, Tomasz J. Nowakowski
Summary: The progenitors of the human neocortex are located in the ventricular and outer subventricular zones. This study demonstrates that astrocytes derived from these zones populate distinct layers and exhibit morphological and molecular differences.
Review
Chemistry, Multidisciplinary
Rouhollah Habibey, Jesus Eduardo Rojo Arias, Johannes Striebel, Volker Busskamp
Summary: Researchers can generate various neuronal cell types and assemble neural circuits using microfluidic technology, which is also widely used in drug development, toxicology studies, neurological disease modeling, and personalized medicine.
Article
Multidisciplinary Sciences
Luis Carrillo-Reid, Weijian Yang, Yuki Bando, Darcy S. Peterka, Rafael Yuste
Article
Biology
Weijian Yang, Luis Carrillo-Reid, Yuki Bando, Darcy S. Peterka, Rafael Yuste
Article
Cell Biology
Yuki Bando, Masayuki Sakamoto, Samuel Kim, Inbal Ayzenshtat, Rafael Yuste
Article
Cell Biology
Krishna Jayant, Michael Wenzel, Yuki Bando, Jordan P. Hamm, Nicola Mandriota, Jake H. Rabinowitz, Ilan Jen-La Plante, Jonathan S. Owen, Ozgur Sahin, Kenneth L. Shepard, Rafael Yuste
Review
Biology
Yuki Bando, Christiane Grimm, Victor H. Cornejo, Rafael Yuste
Review
Cell Biology
Satoru Yamagishi, Yuki Bando, Kohji Sato
Summary: This article discusses the development and migration of cortical neurons in mammals, highlighting the role of cell-cell recognition molecules in regulating proper positioning and projections. Various guidance molecules, such as netrin family proteins and their receptors, are reviewed, with a focus on their attractive and repulsive signals for neuronal migration. The article also explores human genetic disorders associated with these molecules, including congenital mirror movements, schizophrenia, and bipolar disorder.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yuki Bando, Michael Wenzel, Rafael Yuste
Summary: The authors introduced a genetically-encoded voltage indicator to measure subthreshold membrane potentials, combined with two-photon imaging to map epileptic seizures progression. The development of ArcLight-ST allows for specific measurement of subthreshold membrane potentials with cellular resolution. The method demonstrated utility in mapping epileptic seizures progression through cortical circuits.
NATURE COMMUNICATIONS
(2021)
