Control of Mus81 nuclease during the cell cycle

The SMX DNA Repair Tri-nuclease

(2017) Haley D.M. Wyatt et al.   MOLECULAR CELL

Control of structure-specific endonucleases to maintain genome stability

(2017) Pierre-Marie Dehé et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting of the Fun30 nucleosome remodeller by the Dpb11 scaffold facilitates cell cycle-regulated DNA end resection

(2017) Susanne CS Bantele et al.   eLife

Cell cycle control of DNA joint molecule resolution

(2016) Philipp Wild et al.   CURRENT OPINION IN CELL BIOLOGY

A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis

(2016) Heike Duda et al.   DEVELOPMENTAL CELL

RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress

(2016) Rahul Bhowmick et al.   MOLECULAR CELL

Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks

(2016) Sotirios K. Sotiriou et al.   MOLECULAR CELL

Robust Replication Control Is Generated by Temporal Gaps between Licensing and Firing Phases and Depends on Degradation of Firing Factor Sld2

(2016) Karl-Uwe Reusswig et al.   Cell Reports

Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation

(2015) Sophia X. Pfister et al.   CANCER CELL

Replication stress activates DNA repair synthesis in mitosis

(2015) Sheroy Minocherhomji et al.   NATURE

Regulation of Recombination and Genomic Maintenance

(2015) Wolf-Dietrich Heyer   Cold Spring Harbor Perspectives in Biology

Hold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1

(2015) Miguel G. Blanco et al.   Frontiers in Genetics

The Slx4-Dpb11 scaffold complex: coordinating the response to replication fork stalling in S-phase and the subsequent mitosis

(2014) Lissa N Princz et al.   CELL CYCLE

Holliday junction resolution: Regulation in space and time

(2014) Joao Matos et al.   DNA REPAIR

A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication

(2014) D. Gritenaite et al.   GENES & DEVELOPMENT

Human MUS81-EME2 can cleave a variety of DNA structures including intact Holliday junction and nicked duplex

(2014) Tamir Amangyeld et al.   NUCLEIC ACIDS RESEARCH

Top3α Is Required during the Convergent Migration Step of Double Holliday Junction Dissolution

(2014) Stefanie Hartman Chen et al.   PLoS One

End Resection at Double-Strand Breaks: Mechanism and Regulation

(2014) L. S. Symington   Cold Spring Harbor Perspectives in Biology

The Dissolution of Double Holliday Junctions

(2014) A. H. Bizard et al.   Cold Spring Harbor Perspectives in Biology

Sources of DNA Double-Strand Breaks and Models of Recombinational DNA Repair

(2014) A. Mehta et al.   Cold Spring Harbor Perspectives in Biology

MUS81-EME2 Promotes Replication Fork Restart

(2014) Alessandra Pepe et al.   Cell Reports

Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossover

(2013) Barnabas Szakal et al.   EMBO JOURNAL

Cooperative Control of Holliday Junction Resolution and DNA Repair by the SLX1 and MUS81-EME1 Nucleases

(2013) Dennis Castor et al.   MOLECULAR CELL

Coordinated Actions of SLX1-SLX4 and MUS81-EME1 for Holliday Junction Resolution in Human Cells

(2013) Haley D.M. Wyatt et al.   MOLECULAR CELL

ERCC1 and MUS81–EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis

(2013) Valeria Naim et al.   NATURE CELL BIOLOGY

MUS81 promotes common fragile site expression

(2013) Songmin Ying et al.   NATURE CELL BIOLOGY

Regulation of Mus81–Eme1 Holliday junction resolvase in response to DNA damage

(2013) Pierre-Marie Dehé et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Temporal regulation of the Mus81-Mms4 endonuclease ensures cell survival under conditions of DNA damage

(2013) Irene Saugar et al.   NUCLEIC ACIDS RESEARCH

Structure-specific endonucleases: guardians of fragile site stability

(2013) Sheroy Minocherhomji et al.   TRENDS IN CELL BIOLOGY

Repair of Strand Breaks by Homologous Recombination

(2013) M. Jasin et al.   Cold Spring Harbor Perspectives in Biology

Human GEN1 and the SLX4-Associated Nucleases MUS81 and SLX1 Are Essential for the Resolution of Replication-Induced Holliday Junctions

(2013) Elizabeth Garner et al.   Cell Reports

Cell-Cycle Kinases Coordinate the Resolution of Recombination Intermediates with Chromosome Segregation

(2013) Joao Matos et al.   Cell Reports

Structure of C-terminal Tandem BRCT Repeats of Rtt107 Protein Reveals Critical Role in Interaction with Phosphorylated Histone H2A during DNA Damage Repair

(2012) Xinxin Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mus81-Mms4 Functions as a Single Heterodimer To Cleave Nicked Intermediates in Recombinational DNA Repair

(2012) E. K. Schwartz et al.   MOLECULAR AND CELLULAR BIOLOGY

Cyclin-Dependent Kinase Suppression by WEE1 Kinase Protects the Genome through Control of Replication Initiation and Nucleotide Consumption

(2012) H. Beck et al.   MOLECULAR AND CELLULAR BIOLOGY

Cell cycle-dependent regulation of the nuclease activity of Mus81–Eme1/Mms4

(2012) María Gallo-Fernández et al.   NUCLEIC ACIDS RESEARCH

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis

(2011) Joao Matos et al.   CELL

BRCT domains

(2011) Charles Chung Yun Leung et al.   CELL CYCLE

Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes

(2011) Erin K. Schwartz et al.   CHROMOSOMA

Dpb11 coordinates Mec1 kinase activation with cell cycle-regulated Rad9 recruitment

(2011) Boris Pfander et al.   EMBO JOURNAL

Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease

(2011) Raquel Domínguez-Kelly et al.   JOURNAL OF CELL BIOLOGY

Dbf4 Regulates the Cdc5 Polo-like Kinase through a Distinct Non-canonical Binding Interaction

(2010) Ying-Chou Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Damage Signaling Recruits the Rtt107-Slx4 Scaffolds via Dpb11 to Mediate Replication Stress Response

(2010) Patrice Y. Ohouo et al.   MOLECULAR CELL

Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1–Top3

(2010) Petr Cejka et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair

(2009) Jennifer M. Svendsen et al.   CELL

Human SLX4 Is a Holliday Junction Resolvase Subunit that Binds Multiple DNA Repair/Recombination Endonucleases

(2009) Samira Fekairi et al.   CELL

Drosophila MUS312 and the Vertebrate Ortholog BTBD12 Interact with DNA Structure-Specific Endonucleases in DNA Repair and Recombination

(2009) Sabrina L. Andersen et al.   MOLECULAR CELL

Coordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair

(2009) Ivan M. Muñoz et al.   MOLECULAR CELL

Cdc7p-Dbf4p Regulates Mitotic Exit by Inhibiting Polo Kinase

(2009) Charles T. Miller et al.   PLoS Genetics

Structural and Functional Relationships of the XPF/MUS81 Family of Proteins

(2008) Alberto Ciccia et al.   Annual Review of Biochemistry

Dbf4-Dependent Cdc7 Kinase Links DNA Replication to the Segregation of Homologous Chromosomes in Meiosis I

(2008) Joao Matos et al.   CELL

Phosphorylation of the Budding Yeast 9-1-1 Complex Is Required for Dpb11 Function in the Full Activation of the UV-Induced DNA Damage Checkpoint

(2008) F. Puddu et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of Holliday junction resolvases from humans and yeast

(2008) Stephen C. Y. Ip et al.   NATURE

Saccharomyces cerevisiae Mus81-Mms4 is a catalytic, DNA structure-selective endonuclease

(2008) K. T. Ehmsen et al.   NUCLEIC ACIDS RESEARCH