Evaluation of the Efficacy of ChAd63-MVA Vectored Vaccines Expressing Circumsporozoite Protein and ME-TRAP Against Controlled Human Malaria Infection in Malaria-Naive Individuals

Sterile Immunity to Malaria after DNA Prime/Adenovirus Boost Immunization Is Associated with Effector Memory CD8+T Cells Targeting AMA1 Class I Epitopes

(2014) Martha Sedegah et al.   PLoS One

Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection

(2013) Lander Foquet et al.   JOURNAL OF CLINICAL INVESTIGATION

Malaria

(2013) Nicholas J White et al.   LANCET

Efficacy of RTS,S malaria vaccines: individual-participant pooled analysis of phase 2 data

(2013) Philip Bejon et al.   LANCET INFECTIOUS DISEASES

Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP)

(2013) Martha Sedegah et al.   MALARIA JOURNAL

Four-Year Efficacy of RTS,S/AS01E and Its Interaction with Malaria Exposure

(2013) Ally Olotu et al.   NEW ENGLAND JOURNAL OF MEDICINE

DNA Prime/Adenovirus Boost Malaria Vaccine Encoding P. falciparum CSP and AMA1 Induces Sterile Protection Associated with Cell-Mediated Immunity

(2013) Ilin Chuang et al.   PLoS One

Malaria vaccine R&D in the Decade of Vaccines: Breakthroughs, challenges and opportunities

(2013) Ashley J. Birkett et al.   VACCINE

Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation

(2013) Katie J. Ewer et al.   Nature Communications

Human adenovirus 5-vectoredPlasmodium falciparumNMRC-M3V-Ad-PfCA vaccine encoding CSP and AMA1 is safe, well-tolerated and immunogenic but does not protect against controlled human malaria infection

(2013) Cindy Tamminga et al.   Human Vaccines & Immunotherapeutics

Clinical Assessment of a Recombinant Simian Adenovirus ChAd63: A Potent New Vaccine Vector

(2012) Geraldine A. O’Hara et al.   JOURNAL OF INFECTIOUS DISEASES

ChAd63-MVA–vectored Blood-stage Malaria Vaccines Targeting MSP1 and AMA1: Assessment of Efficacy Against Mosquito Bite Challenge in Humans

(2012) Susanne H Sheehy et al.   MOLECULAR THERAPY

A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Phase Ia Clinical Evaluation of the Safety and Immunogenicity of the Plasmodium falciparum Blood-Stage Antigen AMA1 in ChAd63 and MVA Vaccine Vectors

(2012) Susanne H. Sheehy et al.   PLoS One

A Statistical Interaction between Circumsporozoite Protein-Specific T Cell and Antibody Responses and Risk of Clinical Malaria Episodes following Vaccination with RTS,S/AS01E

(2012) Francis M. Ndungu et al.   PLoS One

Vaccine Vectors Derived from a Large Collection of Simian Adenoviruses Induce Potent Cellular Immunity Across Multiple Species

(2012) S. Colloca et al.   Science Translational Medicine

Preventing spontaneous genetic rearrangements in the transgene cassettes of adenovirus vectors

(2011) Matthew G. Cottingham et al.   BIOTECHNOLOGY AND BIOENGINEERING

Phase Ia Clinical Evaluation of the Plasmodium falciparum Blood-stage Antigen MSP1 in ChAd63 and MVA Vaccine Vectors

(2011) Susanne H Sheehy et al.   MOLECULAR THERAPY

Induction of Plasmodium falciparum-Specific CD4+ T Cells and Memory B Cells in Gabonese Children Vaccinated with RTS,S/AS01E and RTS,S/AS02D

(2011) Selidji T. Agnandji et al.   PLoS One

Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8+ T Cell Immunity

(2011) J. E. Epstein et al.   SCIENCE

Protective immunity to pre-erythrocytic stage malaria

(2011) Robert J. Schwenk et al.   TRENDS IN PARASITOLOGY

Prime-boost vectored malaria vaccines: Progress and prospects

(2010) Adrian V. S. Hill et al.   Human vaccines & immunotherapeutics

Prime-Boost Immunization with Adenoviral and Modified Vaccinia Virus Ankara Vectors Enhances the Durability and Polyfunctionality of Protective Malaria CD8+ T-Cell Responses

(2009) A. Reyes-Sandoval et al.   INFECTION AND IMMUNITY

Randomized, Double‐Blind, Phase 2a Trial of Falciparum Malaria Vaccines RTS,S/AS01B and RTS,S/AS02A in Malaria‐Naive Adults: Safety, Efficacy, and Immunologic Associates of Protection

(2009) Kent E. Kester et al.   JOURNAL OF INFECTIOUS DISEASES

Evidence of Blood Stage Efficacy with a Virosomal Malaria Vaccine in a Phase IIa Clinical Trial

(2008) Fiona M. Thompson et al.   PLoS One