Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients?

REM sleep selectively prunes and maintains new synapses in development and learning

(2017) Wei Li et al.   NATURE NEUROSCIENCE

RNCR3 knockdown inhibits diabetes mellitus-induced retinal reactive gliosis

(2016) Chang Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: Sex-dependent microglial signaling in the spinal cord

(2016) Sarah Taves et al.   BRAIN BEHAVIOR AND IMMUNITY

Physical activity and exercise attenuate neuroinflammation in neurological diseases

(2016) Lindsay Joy Spielman et al.   BRAIN RESEARCH BULLETIN

Microglial Physiology and Pathophysiology: Insights from Genome-wide Transcriptional Profiling

(2016) Andrea Crotti et al.   IMMUNITY

Sex differences in neuroimmunity and pain

(2016) Sarah Rosen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mechanisms of microglial activation in models of inflammation and hypoxia: Implications for chronic intermittent hypoxia

(2016) Elizabeth A. Kiernan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cognitive impairment after traumatic brain injury: The role of MRI and possible pathological basis

(2016) Ming-Liang Wang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Analysis of the Metabolic and Structural Brain Changes in Patients With Torture-Related Post-Traumatic Stress Disorder (TR-PTSD) Using 18F-FDG PET and MRI

(2016) Shahin Zandieh et al.   MEDICINE

Pain modulation from the brain during diabetic neuropathy: Uncovering the role of the rostroventromedial medulla

(2016) Marta Silva et al.   NEUROBIOLOGY OF DISEASE

Elevated levels of calcitonin gene-related peptide in upper spinal cord promotes sensitization of primary trigeminal nociceptive neurons

(2016) Lauren E. Cornelison et al.   NEUROSCIENCE

Predicting pain outcomes after traumatic musculoskeletal injury

(2016) Brittany N. Rosenbloom et al.   PAIN

Altered pressure pain thresholds and increased wind-up in adult patients with chronic back pain with a history of childhood maltreatment

(2016) Jonas Tesarz et al.   PAIN

Role of adult hippocampal neurogenesis in persistent pain

(2016) A. Vania Apkarian et al.   PAIN

A ‘complex’ of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients

(2016) L. Becerra et al.   NeuroImage-Clinical

Effect of Minocycline on Lumbar Radicular Neuropathic Pain

(2015) Pascal Vanelderen et al.   ANESTHESIOLOGY

Evidence for brain glial activation in chronic pain patients

(2015) Marco L. Loggia et al.   BRAIN

Antinociceptive properties of selective MT2 melatonin receptor partial agonists

(2015) Martha López-Canul et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Exercise therapy for chronic musculoskeletal pain: Innovation by altering pain memories

(2015) Jo Nijs et al.   MANUAL THERAPY

P38 Phosphorylation in Medullary Microglia Mediates Ectopic Orofacial Inflammatory Pain in Rats

(2015) Masaaki Kiyomoto et al.   Molecular Pain

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

(2015) Robert E Sorge et al.   NATURE NEUROSCIENCE

Microglia in neuronal plasticity: Influence of stress

(2015) Jean-Christophe Delpech et al.   NEUROPHARMACOLOGY

Peripheral and central effects of repeated social defeat stress: Monocyte trafficking, microglial activation, and anxiety

(2015) B.F. Reader et al.   NEUROSCIENCE

Chronic stress and brain plasticity: Mechanisms underlying adaptive and maladaptive changes and implications for stress-related CNS disorders

(2015) Jason Radley et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Exercise therapy normalizes BDNF upregulation and glial hyperactivity in a mouse model of neuropathic pain

(2015) Cayo Almeida et al.   PAIN

Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways

(2015) Martha Lopez-Canul et al.   PAIN

Minocycline protects against lipopolysaccharide-induced cognitive impairment in mice

(2015) Yue Hou et al.   PSYCHOPHARMACOLOGY

Decreased glial reactivity could be involved in the antipsychotic-like effect of cannabidiol

(2015) Felipe V. Gomes et al.   SCHIZOPHRENIA RESEARCH

Effect of Prolonged Moderate Exercise on the Changes of Nonneuronal Cells in Early Myocardial Infarction

(2015) Barbara Rinaldi et al.   NEURAL PLASTICITY

Neural stem/progenitor cells react to non-glial cns neoplasms

(2015) Jack Griffin Campbell et al.   SpringerPlus

Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice

(2014) Gang Chen et al.   BRAIN

Development and pharmacological characterization of a model of sleep disruption-induced hypersensitivity in the rat

(2014) R. Wodarski et al.   EUROPEAN JOURNAL OF PAIN

Brain-derived neurotrophic factor as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?

(2014) Jo Nijs et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Exercise Preconditioning Protects against Spinal Cord Injury in Rats by Upregulating Neuronal and Astroglial Heat Shock Protein 72

(2014) Cheng-Kuei Chang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Involvement of pro- and antinociceptive factors in minocycline analgesia in rat neuropathic pain model

(2014) Ewelina Rojewska et al.   JOURNAL OF NEUROIMMUNOLOGY

PAR2-Mediated Upregulation of BDNF Contributes to Central Sensitization in Bone Cancer Pain

(2014) Yanju Bao et al.   Molecular Pain

BDNF: No gain without pain?

(2014) Peter A. Smith   NEUROSCIENCE

Nerve Pressure Pain Hypersensitivity and Upper Limb Mechanosensitivity in Breast Cancer Survivors: A Case–Control Study

(2014) Elena Caro-Morán et al.   PAIN MEDICINE

Association of Exercise Therapy and Reduction of Pain Sensitivity in Patients With Knee Osteoarthritis: A Randomized Controlled Trial

(2014) Marius Henriksen et al.   ARTHRITIS CARE & RESEARCH

Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice

(2014) Simon Gritsch et al.   Nature Communications

Cerebrospinal Fluid Cytokines and Neurotrophic Factors in Human Chronic Pain Populations: A Comprehensive Review

(2014) Martin F. Bjurstrom et al.   Pain Practice

Overexpression of Heat Shock Protein 72 Attenuates NF-κB Activation Using a Combination of Regulatory Mechanisms in Microglia

(2014) Patrick W. Sheppard et al.   PLoS Computational Biology

Physical exercise increases GFAP expression and induces morphological changes in hippocampal astrocytes

(2013) Lisiani Saur et al.   Brain Structure & Function

Central Sensitization and Altered Central Pain Processing in Chronic Low Back Pain

(2013) Nathalie A. Roussel et al.   CLINICAL JOURNAL OF PAIN

Palmitoylethanolamide Reduces Formalin-Induced Neuropathic-Like Behaviour Through Spinal Glial/Microglial Phenotypical Changes in Mice

(2013) Livio Luongo et al.   CNS & Neurological Disorders-Drug Targets

Protease-activated receptor 2 in dorsal root ganglion contributes to peripheral sensitization of bone cancer pain

(2013) S. Liu et al.   EUROPEAN JOURNAL OF PAIN

The A1 adenosine receptor as a new player in microglia physiology

(2013) L. Luongo et al.   GLIA

The Central Sensitization Inventory (CSI): Establishing Clinically Significant Values for Identifying Central Sensitivity Syndromes in an Outpatient Chronic Pain Sample

(2013) Randy Neblett et al.   JOURNAL OF PAIN

Emerging roles of astrocytes in neural circuit development

(2013) Laura E. Clarke et al.   NATURE REVIEWS NEUROSCIENCE

microRNAs and the regulation of neuronal plasticity under stress conditions

(2013) M. Schouten et al.   NEUROSCIENCE

Glial Biology in Learning and Cognition

(2013) R. Douglas Fields et al.   NEUROSCIENTIST

One night of total sleep deprivation promotes a state of generalized hyperalgesia: A surrogate pain model to study the relationship of insomnia and pain

(2013) Sigrid Schuh-Hofer et al.   PAIN

Glia and pain: Is chronic pain a gliopathy?

(2013) Ru-Rong Ji et al.   PAIN

Pain Treatment for Patients With Osteoarthritis and Central Sensitization

(2013) Enrique Lluch Girbés et al.   PHYSICAL THERAPY

Basolateral Amygdala Lesion Inhibits the Development of Pain Chronicity in Neuropathic Pain Rats

(2013) Zheng Li et al.   PLoS One

Microglia Control Neuronal Network Excitability via BDNF Signalling

(2013) Francesco Ferrini et al.   NEURAL PLASTICITY

Physical exercise modulates peripheral levels of brain-derived neurotrophic factor (BDNF): A systematic review of experimental studies in the elderly

(2012) Flávia Gomes de Melo Coelho et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Thermal Hyperalgesia Distinguishes Those With Severe Pain and Disability in Unilateral Lateral Epicondylalgia

(2012) Brooke K. Coombes et al.   CLINICAL JOURNAL OF PAIN

Evidence for central sensitization in chronic whiplash: A systematic literature review

(2012) J. Van Oosterwijck et al.   EUROPEAN JOURNAL OF PAIN

Commentary on Landry et al.: “Propentofylline, a CNS glial modulator, does not decrease pain in post-herpetic neuralgia patients: In vitro evidence for differential responses in human and rodent microglia and macrophages”

(2012) Linda R. Watkins et al.   EXPERIMENTAL NEUROLOGY

Salvinorin A Reduces Mechanical Allodynia and Spinal Neuronal Hyperexcitability Induced by Peripheral Formalin Injection

(2012) Francesca Guida et al.   Molecular Pain

Stress, anxiety, and dendritic spines: What are the connections?

(2012) B. Leuner et al.   NEUROSCIENCE

The emerging field of pain epigenetics

(2012) Laura S. Stone et al.   PAIN

Schizophrenia: Linking prenatal infection to cytokines, the tryptophan catabolite (TRYCAT) pathway, NMDA receptor hypofunction, neurodevelopment and neuroprogression

(2012) George Anderson et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Cerebral microglia mediate sleep/wake and neuroinflammatory effects of methamphetamine

(2011) Jonathan P. Wisor et al.   BRAIN BEHAVIOR AND IMMUNITY

Fractalkine/CX3CR1 Signalling in Chronic Pain and Inflammation

(2011) Anna K. Clark et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

In the mind or in the brain? Scientific evidence for central sensitisation in chronic fatigue syndrome

(2011) Jo Nijs et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: In vitro evidence for differential responses in human and rodent microglia and macrophages

(2011) Russell P. Landry et al.   EXPERIMENTAL NEUROLOGY

Spinal Cord Toll-Like Receptor 4 Mediates Inflammatory and Neuropathic Hypersensitivity in Male But Not Female Mice

(2011) R. E. Sorge et al.   JOURNAL OF NEUROSCIENCE

 -Adrenergic Receptor Antagonism Prevents Anxiety-Like Behavior and Microglial Reactivity Induced by Repeated Social Defeat

(2011) E. S. Wohleb et al.   JOURNAL OF NEUROSCIENCE

Stress and anxiety: Structural plasticity and epigenetic regulation as a consequence of stress

(2011) Bruce S. McEwen et al.   NEUROPHARMACOLOGY

Microglial Morphology and Dynamic Behavior Is Regulated by Ionotropic Glutamatergic and GABAergic Neurotransmission

(2011) Aurora M. Fontainhas et al.   PLoS One

Do patients with chronic patellar tendinopathy have an altered somatosensory profile? - A Quantitative Sensory Testing (QST) study

(2011) C. P. van Wilgen et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

Central Sensitization in Patients with Rheumatoid Arthritis: A Systematic Literature Review

(2011) Mira Meeus et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Protease-activated receptor 2 signaling in inflammation

(2011) Andrea S. Rothmeier et al.   Seminars in Immunopathology

Sleep loss and inflammation

(2010) Janet M. Mullington et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Brain-derived neurotrophic factor contributes to spinal long-term potentiation and mechanical hypersensitivity by activation of spinal microglia in rat

(2010) Li-Jun Zhou et al.   BRAIN BEHAVIOR AND IMMUNITY

Conditioned pain modulation (the diffuse noxious inhibitory control-like effect): its relevance for acute and chronic pain states

(2010) David Yarnitsky   Current Opinion in Anesthesiology

Evidence of Central and Peripheral Sensitization in a Rat Model of Narcotic Bowel-Like Syndrome

(2010) Simona Agostini et al.   GASTROENTEROLOGY

The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines

(2010) Paul J. Austin et al.   JOURNAL OF NEUROIMMUNOLOGY

Interactions between the immune and nervous systems in pain

(2010) Ke Ren et al.   NATURE MEDICINE

Central sensitization: Implications for the diagnosis and treatment of pain

(2010) Clifford J. Woolf   PAIN

The efficacy of cognitive-behavioral therapy for insomnia in patients with chronic pain

(2010) Carla R. Jungquist et al.   SLEEP MEDICINE

Neuroplasticity – Exercise-Induced Response of Peripheral Brain-Derived Neurotrophic Factor

(2010) Kristel Knaepen et al.   SPORTS MEDICINE

Sensitisation of spinal cord pain processing in medication overuse headache involves supraspinal pain control

(2009) A Perrotta et al.   CEPHALALGIA

Widespread Mechanical Pain Hypersensitivity as Sign of Central Sensitization in Unilateral Epicondylalgia

(2009) Josué Fernández-Carnero et al.   CLINICAL JOURNAL OF PAIN

Astroglia in Medullary Dorsal Horn (Trigeminal Spinal Subnucleus Caudalis) Are Involved in Trigeminal Neuropathic Pain Mechanisms

(2009) A. Okada-Ogawa et al.   JOURNAL OF NEUROSCIENCE

Recognition of central sensitization in patients with musculoskeletal pain: Application of pain neurophysiology in manual therapy practice

(2009) Jo Nijs et al.   MANUAL THERAPY

Activation of the prostaglandin system in response to sleep loss in healthy humans: Potential mediator of increased spontaneous pain

(2009) Monika Haack et al.   PAIN

White and gray matter abnormalities in the brain of patients with fibromyalgia: A diffusion-tensor and volumetric imaging study

(2008) Jürgen Lutz et al.   ARTHRITIS AND RHEUMATISM

Central mechanisms of experimental and chronic neuropathic pain: Findings from functional imaging studies

(2008) F. Seifert et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Brain activity associated with slow temporal summation of C-fiber evoked pain in fibromyalgia patients and healthy controls

(2008) Roland Staud et al.   EUROPEAN JOURNAL OF PAIN

Activation of JNK pathway in persistent pain

(2008) Yong-Jing Gao et al.   NEUROSCIENCE LETTERS