TGFβ as a therapeutic target in cystic fibrosis

TGF-β1 Evokes Human Airway Smooth Muscle Cell Shortening and Hyperresponsiveness via Smad3

(2018) Christie A. Ojiaku et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Impact of azithromycin on the clinical and antimicrobial effectiveness of tobramycin in the treatment of cystic fibrosis

(2017) Dave P. Nichols et al.   Journal of Cystic Fibrosis

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

(2017) Rajesha Rupaimoole et al.   NATURE REVIEWS DRUG DISCOVERY

TGFΒ-induced transcription in cancer

(2017) Gaia Cantelli et al.   SEMINARS IN CANCER BIOLOGY

Systematic Review and Network Meta-analysis of Idiopathic Pulmonary Fibrosis Treatments

(2017) Kelly Fleetwood et al.   Journal of Managed Care & Specialty Pharmacy

In the Shadow of Fibrosis: Innate Immune Suppression Mediated by Transforming Growth Factor-β

(2016) Belinda J. Thomas et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Transforming Growth Factor-β: Master Regulator of the Respiratory System in Health and Disease

(2016) Yael Aschner et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Hypoxia and sterile inflammation in cystic fibrosis airways: mechanisms and potential therapies

(2016) Samuel T. Montgomery et al.   EUROPEAN RESPIRATORY JOURNAL

Eradication of methicillin resistantStaphylococcus aureusdetected for the first time in cystic fibrosis: A single center observational study

(2016) Matthias Kappler et al.   PEDIATRIC PULMONOLOGY

RPTOR, a novel target of miR-155, elicits a fibrotic phenotype of cystic fibrosis lung epithelium by upregulating CTGF

(2016) Motohiro Tsuchiya et al.   RNA Biology

miR-1343 attenuates pathways of fibrosis by targeting the TGF-  receptors

(2015) L. R. Stolzenburg et al.   BIOCHEMICAL JOURNAL

Impact of Sustained Eradication of NewPseudomonas aeruginosaInfection on Long-term Outcomes in Cystic Fibrosis

(2015) Nicole Mayer-Hamblett et al.   CLINICAL INFECTIOUS DISEASES

Airway Surface Dehydration by Transforming Growth Factor β (TGF-β) in Cystic Fibrosis Is Due to Decreased Function of a Voltage-dependent Potassium Channel and Can Be Rescued by the Drug Pirfenidone

(2015) Dahis Manzanares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defective goblet cell exocytosis contributes to murine cystic fibrosis–associated intestinal disease

(2015) Jinghua Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA Dysregulation in Cystic Fibrosis

(2015) Paul J. McKiernan et al.   MEDIATORS OF INFLAMMATION

Origins of Cystic Fibrosis Lung Disease

(2015) David A. Stoltz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR

(2015) Claire E. Wainwright et al.   NEW ENGLAND JOURNAL OF MEDICINE

Predicting future lung function decline in cystic fibrosis patients: Statistical methods and clinical connections

(2015) Rhonda D. Szczesniak et al.   PEDIATRIC PULMONOLOGY

Eosinophilic pneumonias in children: A review of the epidemiology, diagnosis, and treatment

(2015) Lisa Giovannini-Chami et al.   PEDIATRIC PULMONOLOGY

Targeting the TGFβ pathway for cancer therapy

(2015) Cindy Neuzillet et al.   PHARMACOLOGY & THERAPEUTICS

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis

(2015) Harriet Corvol et al.   Nature Communications

Cystic fibrosis-adapted Pseudomonas aeruginosa quorum sensing lasR mutants cause hyperinflammatory responses

(2015) S. L. LaFayette et al.   Science Advances

Improving the efficacy of inhaled drugs in cystic fibrosis: Challenges and emerging drug delivery strategies

(2014) Ivana d'Angelo et al.   ADVANCED DRUG DELIVERY REVIEWS

Identification of a Cell-of-Origin for Fibroblasts Comprising the Fibrotic Reticulum in Idiopathic Pulmonary Fibrosis

(2014) Hong Xia et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeting EGFR signalling in chronic lung disease: therapeutic challenges and opportunities

(2014) S. Vallath et al.   EUROPEAN RESPIRATORY JOURNAL

Targeting RAS–ERK signalling in cancer: promises and challenges

(2014) Ahmed A. Samatar et al.   NATURE REVIEWS DRUG DISCOVERY

Cystic fibrosis genetics: from molecular understanding to clinical application

(2014) Garry R. Cutting   NATURE REVIEWS GENETICS

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

(2014) Talmadge E. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

TGF-Beta Downregulation of Distinct Chloride Channels in Cystic Fibrosis-Affected Epithelia

(2014) Hongtao Sun et al.   PLoS One

Transforming growth factor β and severe asthma: A perfect storm

(2014) Mazen Al-Alawi et al.   RESPIRATORY MEDICINE

Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis

(2014) M. J. Hoegger et al.   SCIENCE

The hierarchy quorum sensing network in Pseudomonas aeruginosa

(2014) Jasmine Lee et al.   Protein & Cell

Ataluren for the treatment of nonsense-mutation cystic fibrosis: a randomised, double-blind, placebo-controlled phase 3 trial

(2014) Eitan Kerem et al.   Lancet Respiratory Medicine

The Impact of Cystic Fibrosis on the Immunologic Profile of Pediatric Patients

(2013) Daniela M. Bernardi et al.   Jornal de Pediatria

Signaling between Transforming Growth Factor β (TGF-β) and Transcription Factor SNAI2 Represses Expression of MicroRNA miR-203 to Promote Epithelial-Mesenchymal Transition and Tumor Metastasis

(2013) Xiangming Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Cystic Fibrosis Transmembrane Conductance Regulator by MicroRNA-145, -223, and -494 Is Altered in  F508 Cystic Fibrosis Airway Epithelium

(2013) I. K. Oglesby et al.   JOURNAL OF IMMUNOLOGY

Normal mucus formation requires cAMP-dependent HCO3−secretion and Ca2+-mediated mucin exocytosis

(2013) Ning Yang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Risk Factors for Bronchiectasis in Children with Cystic Fibrosis

(2013) Peter D. Sly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dysregulated Proinflammatory and Fibrogenic Phenotype of Fibroblasts in Cystic Fibrosis

(2013) François Huaux et al.   PLoS One

Tgf-β1 Inhibits Cftr Biogenesis and Prevents Functional Rescue of ΔF508-Cftr in Primary Differentiated Human Bronchial Epithelial Cells

(2013) Steven M. Snodgrass et al.   PLoS One

Myofibroblast Differentiation and Enhanced Tgf-B Signaling in Cystic Fibrosis Lung Disease

(2013) William T. Harris et al.   PLoS One

Airway inflammation in cystic fibrosis: molecular mechanisms and clinical implications

(2013) Malena Cohen-Cymberknoh et al.   THORAX

CFTR, Mucins, and Mucus Obstruction in Cystic Fibrosis

(2013) S. M. Kreda et al.   Cold Spring Harbor Perspectives in Medicine

Effect of Simvastatin on Transforming Growth Factor Beta-1–Induced Myofibroblast Differentiation and Collagen Production in Nasal Polyp-Derived Fibroblasts

(2012) Il-Ho Park et al.   American Journal of Rhinology & Allergy

Amphiregulin, an Epidermal Growth Factor Receptor Ligand, Plays an Essential Role in the Pathogenesis of Transforming Growth Factor-β-induced Pulmonary Fibrosis

(2012) Yang Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia

(2012) B. Button et al.   SCIENCE

Crosstalk between TGF-β signaling and the microRNA machinery

(2012) Henriett Butz et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

microRNA regulation of expression of the cystic fibrosis transmembrane conductance regulator gene

(2011) Austin E. Gillen et al.   BIOCHEMICAL JOURNAL

Idiopathic pulmonary fibrosis

(2011) Talmadge E King et al.   LANCET

A CFTR Potentiator in Patients with Cystic Fibrosis and theG551DMutation

(2011) Bonnie W. Ramsey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Plasma TGF-β1 in pediatric cystic fibrosis: Potential biomarker of lung disease and response to therapy

(2011) William T. Harris et al.   PEDIATRIC PULMONOLOGY

Effect of Temperature on Cystic Fibrosis Lung Disease and Infections: A Replicated Cohort Study

(2011) Joseph M. Collaco et al.   PLoS One

Evolution of pulmonary inflammation and nutritional status in infants and young children with cystic fibrosis

(2011) S. C. Ranganathan et al.   THORAX

Role of epithelial HCO3− transport in mucin secretion: lessons from cystic fibrosis

(2010) Paul M. Quinton   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

TGF-β Signaling Specifies Axons during Brain Development

(2010) Jason J. Yi et al.   CELL

Loss of Anion Transport without Increased Sodium Absorption Characterizes Newborn Porcine Cystic Fibrosis Airway Epithelia

(2010) Jeng-Haur Chen et al.   CELL

Epithelium-specific deletion of TGF-β receptor type II protects mice from bleomycin-induced pulmonary fibrosis

(2010) Min Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Smad Proteins Bind a Conserved RNA Sequence to Promote MicroRNA Maturation by Drosha

(2010) Brandi N. Davis et al.   MOLECULAR CELL

Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth

(2010) D. A. Stoltz et al.   Science Translational Medicine

TGF-β Signaling May Play a Role in the Development of Goblet Cell Hyperplasia in a Mouse Model of Allergic Rhinitis

(2010) Yuhui Ouyang et al.   ALLERGOLOGY INTERNATIONAL

Mepacrine inhibits subepithelial fibrosis by reducing the expression of arginase and TGF-β1 in an extended subacute mouse model of allergic asthma

(2009) Ulaganathan Mabalirajan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Transforming Growth Factor-β Enhances Rhinovirus Infection by Diminishing Early Innate Responses

(2009) Belinda J. Thomas et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Anti-inflammatory and pro-inflammatory roles of TGF-β, IL-10, and IL-22 in immunity and autoimmunity

(2009) Shomyseh Sanjabi et al.   CURRENT OPINION IN PHARMACOLOGY

Transforming growth factor-β1in bronchoalveolar lavage fluid from children with cystic fibrosis

(2009) William T. Harris et al.   PEDIATRIC PULMONOLOGY

Pulmonary Complications of Cystic Fibrosis

(2009) Patrick A Flume   Respiratory Care

PPAR-γ agonists inhibit TGF-β1-induced chemokine expression in human tubular epithelial cells

(2008) Wei-ming Wang et al.   ACTA PHARMACOLOGICA SINICA

Persistent Methicillin-resistantStaphylococcus aureusand Rate of FEV1Decline in Cystic Fibrosis

(2008) Elliott C. Dasenbrook et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Update on gene modifiers in cystic fibrosis

(2008) Joseph M Collaco et al.   CURRENT OPINION IN PULMONARY MEDICINE

Therapeutic potential of inhaled p38 mitogen-activated protein kinase inhibitors for inflammatory pulmonary diseases

(2008) Puneet Chopra et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The role of quorum sensing in chronic cystic fibrosisPseudomonas aeruginosainfections

(2008) Craig Winstanley et al.   FEMS MICROBIOLOGY LETTERS

MicroRNA-155 Is Regulated by the Transforming Growth Factor  /Smad Pathway and Contributes to Epithelial Cell Plasticity by Targeting RhoA

(2008) W. Kong et al.   MOLECULAR AND CELLULAR BIOLOGY

SMAD proteins control DROSHA-mediated microRNA maturation

(2008) Brandi N. Davis et al.   NATURE

Association of a Polymorphism of the Transforming Growth Factor-β1 Gene with Genetic Susceptibility to Osteoporosis in Postmenopausal Japanese Women

(2006) Yoshiji Yamada et al.   JOURNAL OF BONE AND MINERAL RESEARCH