In the Shadow of Fibrosis: Innate Immune Suppression Mediated by Transforming Growth Factor-β

Transforming Growth Factor-β: Master Regulator of the Respiratory System in Health and Disease

(2016) Yael Aschner et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pseudomonas aeruginosa Evolutionary Adaptation and Diversification in Cystic Fibrosis Chronic Lung Infections

(2016) Craig Winstanley et al.   TRENDS IN MICROBIOLOGY

TGF-β-induced IL-6 prevents development of acute lung injury in influenza A virus-infected F508del CFTR-heterozygous mice

(2015) Parker S. Woods et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The immune suppressive function of transforming growth factor-β(TGF-β) in human diseases

(2015) Jingyi Sheng et al.   GROWTH FACTORS

Pirfenidone for Idiopathic Pulmonary Fibrosis: A Systematic Review and Meta-Analysis

(2015) Carlos Aravena et al.   PLoS One

γ-Herpes virus-68, but not Pseudomonas aeruginosa or influenza A (H1N1), exacerbates established murine lung fibrosis

(2014) Shanna L. Ashley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Role of Bacteria in the Pathogenesis and Progression of Idiopathic Pulmonary Fibrosis

(2014) Phillip L. Molyneaux et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Innate Antiviral Host Defense Attenuates TGF-β Function through IRF3-Mediated Suppression of Smad Signaling

(2014) Pinglong Xu et al.   MOLECULAR CELL

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

(2014) Talmadge E. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

Influenza viral neuraminidase primes bacterial coinfection through TGF-β–mediated expression of host cell receptors

(2014) Ning Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NK1.1+ CD8+ T cells escape TGF-β control and contribute to early microbial pathogen response

(2014) Anne L. Ruiz et al.   Nature Communications

Outgrowth of the Bacterial Airway Microbiome after Rhinovirus Exacerbation of Chronic Obstructive Pulmonary Disease

(2013) Philip L. Molyneaux et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TGF-β Activation and Function in Immunity

(2013) Mark A. Travis et al.   Annual Review of Immunology

Viral and bacterial infection in acute asthma and chronic obstructive pulmonary disease increases the risk of readmission

(2013) Peter A.B. Wark et al.   RESPIROLOGY

Synergistic and feedback signaling mechanisms in the regulation of inflammation in respiratory infections

(2012) Wenzhuo Y Wang et al.   Cellular & Molecular Immunology

The symphony of the ninth: the development and function of Th9 cells

(2012) Rukhsana Jabeen et al.   CURRENT OPINION IN IMMUNOLOGY

Differential role of regulatory T cells in early and late stages of pulmonary fibrosis

(2012) Daniel Boveda-Ruiz et al.   IMMUNOBIOLOGY

Airway TGF-β1 and oxidant stress in children with severe asthma: Association with airflow limitation

(2012) Sheena D. Brown et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TGF-β is responsible for NK cell immaturity during ontogeny and increased susceptibility to infection during mouse infancy

(2012) Jeffrey P Marcoe et al.   NATURE IMMUNOLOGY

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

Transforming Growth Factor-Beta Promotes Rhinovirus Replication in Bronchial Epithelial Cells by Suppressing the Innate Immune Response

(2012) Nicole Bedke et al.   PLoS One

Pirfenidone inhibits TGF-β1-induced over-expression of collagen type I and heat shock protein 47 in A549 cells

(2012) Keiko Hisatomi et al.   BMC Pulmonary Medicine

Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages

(2011) Luke Barron et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Viral Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis

(2011) Sharon Chao Wootton et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Adaptive and Innate Transforming Growth Factor   Signaling Impact Herpes Simplex Virus 1 Latency and Reactivation

(2011) S. J. Allen et al.   JOURNAL OF VIROLOGY

Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors

(2011) Mark J. Anderton et al.   TOXICOLOGIC PATHOLOGY

Viruses and bacteria in acute asthma exacerbations - A GA2LEN-DARE* systematic review

(2010) N. G. Papadopoulos et al.   ALLERGY

Reduced SMAD7 Leads to Overactivation of TGF-  Signaling in MDS that Can Be Reversed by a Specific Inhibitor of TGF-  Receptor I Kinase

(2010) L. Zhou et al.   CANCER RESEARCH

Acute exacerbation of idiopathic pulmonary fibrosis: incidence, risk factors and outcome

(2010) J. W. Song et al.   EUROPEAN RESPIRATORY JOURNAL

Role of viral respiratory infections in asthma and asthma exacerbations

(2010) William W Busse et al.   LANCET

Transforming Growth Factor-β: Activation by Neuraminidase and Role in Highly Pathogenic H5N1 Influenza Pathogenesis

(2010) Christina M. Carlson et al.   PLoS Pathogens

Transforming Growth Factor-β Enhances Rhinovirus Infection by Diminishing Early Innate Responses

(2009) Belinda J. Thomas et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cell Cycle Arrest by Transforming Growth Factor  1 Enhances Replication of Respiratory Syncytial Virus in Lung Epithelial Cells

(2009) J. D. Gibbs et al.   JOURNAL OF VIROLOGY

Transforming growth factor-β1in bronchoalveolar lavage fluid from children with cystic fibrosis

(2009) William T. Harris et al.   PEDIATRIC PULMONOLOGY

Exacerbation of Established Pulmonary Fibrosis in a Murine Model by Gammaherpesvirus

(2008) Tracy R. McMillan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

(2008) Elisabetta Volpe et al.   NATURE IMMUNOLOGY

Partial Inhibition of Integrin αvβ6 Prevents Pulmonary Fibrosis without Exacerbating Inflammation

(2007) Gerald S. Horan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE