Hepatitis B core protein as a therapeutic target

The potential and challenges of CRISPR-Cas in eradication of hepatitis B virus covalently closed circular DNA

(2018) Hung-Chih Yang et al.   VIRUS RESEARCH

Prolonged RNA interference therapy with ARC-520 Injection in treatment naïve, HBeAg positive and negative patients with chronic HBV results in significant reductions of HBs antigen

(2017) M.-F. Yuen et al.   JOURNAL OF HEPATOLOGY

EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

(2017) Pietro Lampertico et al.   JOURNAL OF HEPATOLOGY

Complete and Incomplete Hepatitis B Virus Particles: Formation, Function, and Application

(2017) Jianming Hu et al.   Viruses-Basel

Removal of Integrated Hepatitis B Virus DNA Using CRISPR-Cas9

(2017) Hao Li et al.   Frontiers in Cellular and Infection Microbiology

Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms

(2017) Zheng Zhou et al.   Scientific Reports

Effect of a hepatitis B virus inhibitor, NZ-4, on capsid formation

(2016) Li Yang et al.   ANTIVIRAL RESEARCH

NVR 3-778, a First-in-Class HBV Core Inhibitor, Alone and in Combination with Peg-Interferon (PegIFN), in Treatment-Naive HBeAg-Positive Patients: Early Reductions in HBV DNA and HBeAg

(2016) M.-F. Yuen et al.   JOURNAL OF HEPATOLOGY

Cell-Free Hepatitis B Virus Capsid Assembly Dependent on the Core Protein C-Terminal Domain and Regulated by Phosphorylation

(2016) Laurie Ludgate et al.   JOURNAL OF VIROLOGY

Hepatitis B virus basal core promoter mutations show lower replication fitness associated with cccDNA acetylation status

(2016) Lemonica Koumbi et al.   VIRUS RESEARCH

Core protein: A pleiotropic keystone in the HBV lifecycle

(2015) Adam Zlotnick et al.   ANTIVIRAL RESEARCH

Anti capsid drugs HAP12 and AT130 target HBV core protein nuclear functions

(2015) L. Belloni et al.   DIGESTIVE AND LIVER DISEASE

Genome-free hepatitis B virion levels in patient sera as a potential marker to monitor response to antiviral therapy

(2014) L. Luckenbaugh et al.   JOURNAL OF VIRAL HEPATITIS

Phosphoacceptors Threonine 162 and Serines 170 and 178 within the Carboxyl-Terminal RRRS/T Motif of the Hepatitis B Virus Core Protein Make Multiple Contributions to Hepatitis B Virus Replication

(2014) J. Jung et al.   JOURNAL OF VIROLOGY

Transcription of Hepatitis B Virus Covalently Closed Circular DNA Is Regulated by CpG Methylation during Chronic Infection

(2014) Yongmei Zhang et al.   PLoS One

Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses

(2014) Christian Königer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA

(2014) J. Lucifora et al.   SCIENCE

The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo

(2014) Su-Ru Lin et al.   Molecular Therapy-Nucleic Acids

Targeting Hepatitis B Virus With CRISPR/Cas9

(2014) Christoph Seeger et al.   Molecular Therapy-Nucleic Acids

Preclinical Characterization of GLS4, an Inhibitor of Hepatitis B Virus Core Particle Assembly

(2013) Guoyi Wu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Hepatitis B virus core protein enhances human telomerase reverse transcriptase expression and hepatocellular carcinoma cell proliferation in a c-Ets2-dependent manner

(2013) Xiaoxiao Gai et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

378 HEPATITIS B CORE (HBC) PROTEIN IS A KEY AND VERY EARLY NEGATIVE REGULATOR OF THE INTERFERON RESPONSE

(2013) M. Gruffaz et al.   JOURNAL OF HEPATOLOGY

Nucleic Acid Chaperone Activity Associated with the Arginine-Rich Domain of Human Hepatitis B Virus Core Protein

(2013) T.-H. Chu et al.   JOURNAL OF VIROLOGY

Sulfamoylbenzamide Derivatives Inhibit the Assembly of Hepatitis B Virus Nucleocapsids

(2013) M. R. Campagna et al.   JOURNAL OF VIROLOGY

Maturation-Associated Destabilization of Hepatitis B Virus Nucleocapsid

(2013) X. Cui et al.   JOURNAL OF VIROLOGY

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Identification of Disubstituted Sulfonamide Compounds as Specific Inhibitors of Hepatitis B Virus Covalently Closed Circular DNA Formation

(2012) Dawei Cai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phase Diagrams Map the Properties of Antiviral Agents Directed against Hepatitis B Virus Core Assembly

(2012) Lichun Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Hepatitis B surface antigen levels: association with 5-year response to peginterferon alfa-2a in hepatitis B e-antigen-negative patients

(2012) Patrick Marcellin et al.   Hepatology International

Characterization of Nucleosome Positioning in Hepadnaviral Covalently Closed Circular DNA Minichromosomes

(2012) Liping Shi et al.   JOURNAL OF VIROLOGY

HBc binds to the CpG islands of HBV cccDNA and promotes an epigenetic permissive state

(2011) Yan-Hai Guo et al.   Epigenetics

Hepatitis B Virus Core Protein Variations Differ in Tumor and Adjacent Nontumor Tissues from Patients with Hepatocellular Carcinoma

(2011) Yu Zhu et al.   INTERVIROLOGY

Trapping of Hepatitis B Virus Capsid Assembly Intermediates by Phenylpropenamide Assembly Accelerators

(2010) Sarah P. Katen et al.   ACS Chemical Biology

Inhibition of hepatitis B virus replication by the internal fragment of hepatitis B core protein

(2010) Jinchao Han et al.   VIRUS RESEARCH

Hepatitis B Virus Core Variants Modify Natural Course of Viral Infection and Hepatocellular Carcinoma Progression

(2009) Feng–Yu Sung et al.   GASTROENTEROLOGY

Production and Function of the Cytoplasmic Deproteinized Relaxed Circular DNA of Hepadnaviruses

(2009) H. Guo et al.   JOURNAL OF VIROLOGY

Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function

(2009) L. Belloni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of mutations in core protein of hepatitis B virus in liver fibrosis

(2009) Ashraf Mohamadkhani et al.   Virology Journal

Hepatitis B virus core protein inhibits TRAIL-induced apoptosis of hepatocytes by blocking DR5 expression

(2008) J Du et al.   CELL DEATH AND DIFFERENTIATION

HBsAg Seroclearance in Chronic Hepatitis B in Asian Patients: Replicative Level and Risk of Hepatocellular Carcinoma

(2008) Man–Fung Yuen et al.   GASTROENTEROLOGY

Core mutations in patients with acute episodes of chronic HBV infection are associated with the emergence of new immune recognition sites and the development of high IgM anti-HBc index values

(2008) Alexandra Alexopoulou et al.   JOURNAL OF MEDICAL VIROLOGY

Small-Molecule Effectors of Hepatitis B Virus Capsid Assembly Give Insight into Virus Life Cycle

(2008) C. Bourne et al.   JOURNAL OF VIROLOGY