Removal of Integrated Hepatitis B Virus DNA Using CRISPR-Cas9

Nested case-control study: hepatocellular carcinoma risk after hepatitis B surface antigen seroclearance

(2016) P. P. Gounder et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

An Effective Molecular Target Site in Hepatitis B Virus S Gene for Cas9 Cleavage and Mutational Inactivation

(2016) Hao Li et al.   International Journal of Biological Sciences

Multidrug resistance protein 4 is a critical protein associated with the antiviral efficacy of nucleos(t)ide analogues

(2016) Wei Liu et al.   LIVER INTERNATIONAL

Complete Spectrum of CRISPR/Cas9-induced Mutations on HBV cccDNA

(2016) Christoph Seeger et al.   MOLECULAR THERAPY

Metabolism and function of hepatitis B virus cccDNA: Implications for the development of cccDNA-targeting antiviral therapeutics

(2015) Ju-Tao Guo et al.   ANTIVIRAL RESEARCH

Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities

(2015) Robert G. Gish et al.   ANTIVIRAL RESEARCH

Targeting hepatitis B virus cccDNA by CRISPR/Cas9 nuclease efficiently inhibits viral replication

(2015) Chunsheng Dong et al.   ANTIVIRAL RESEARCH

Harnessing the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated Cas9 system to disrupt the hepatitis B virus

(2015) S Zhen et al.   GENE THERAPY

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B

(2015) Michael Nassal   GUT

Inhibition of hepatitis B virus by the CRISPR/Cas9 system via targeting the conserved regions of the viral genome

(2015) Xing Liu et al.   JOURNAL OF GENERAL VIROLOGY

Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease

(2015) Edward M. Kennedy et al.   VIROLOGY

Dual gRNAs guided CRISPR/Cas9 system inhibits hepatitis B virus replication

(2015) Jie Wang   WORLD JOURNAL OF GASTROENTEROLOGY

CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus

(2015) Vyas Ramanan et al.   Scientific Reports

CRISPR/Cas9 nickase-mediated disruption of hepatitis B virus open reading frame S and X

(2015) Madina Karimova et al.   Scientific Reports

CRISPR/Cas9-based tools for targeted genome editing and replication control of HBV

(2015) Cheng Peng et al.   VIROLOGICA SINICA

CRISPR/Cas9 for genome editing: progress, implications and challenges

(2014) F. Zhang et al.   HUMAN MOLECULAR GENETICS

RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection

(2014) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Short- and long-term outcome of interferon therapy for chronic hepatitis B infection

(2014) Yasushi Seo   WORLD JOURNAL OF GASTROENTEROLOGY

Management of antiviral drug resistance in chronic hepatitis B

(2014) Ki Bae Bang   WORLD JOURNAL OF GASTROENTEROLOGY

Molecular mechanism of hepatitis B virus-induced hepatocarcinogenesis

(2014) Mirko Tarocchi   WORLD JOURNAL OF GASTROENTEROLOGY

Role of hepatitis B virus DNA integration in human hepatocarcinogenesis

(2014) Hoang Hai   WORLD JOURNAL OF GASTROENTEROLOGY

The CRISPR/Cas9 System Facilitates Clearance of the Intrahepatic HBV Templates In Vivo

(2014) Su-Ru Lin et al.   Molecular Therapy-Nucleic Acids

Targeting Hepatitis B Virus With CRISPR/Cas9

(2014) Christoph Seeger et al.   Molecular Therapy-Nucleic Acids

Hepatitis B virus-induced hepatocellular carcinoma

(2013) Cheng Xu et al.   CANCER LETTERS

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

(2013) Lei S. Qi et al.   CELL

Inactivation of Hepatitis B Virus Replication in Cultured Cells and In Vivo with Engineered Transcription Activator-Like Effector Nucleases

(2013) Kristie Bloom et al.   MOLECULAR THERAPY

An Efficient Antiviral Strategy for Targeting Hepatitis B Virus Genome Using Transcription Activator-Like Effector Nucleases

(2013) Jieliang Chen et al.   MOLECULAR THERAPY

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients

(2012) Z. Jiang et al.   GENOME RESEARCH

Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

(2012) Wing-Kin Sung et al.   NATURE GENETICS

Re-evaluation of the Carcinogenic Significance of Hepatitis B Virus Integration in Hepatocarcinogenesis

(2012) Suzhen Jiang et al.   PLoS One

The Hepatitis B Virus X Protein Inhibits Thymine DNA Glycosylase Initiated Base Excision Repair

(2012) Maarten A. A. van de Klundert et al.   PLoS One

Quantitation of HBV covalently closed circular DNA in micro formalin fixed paraffin-embedded liver tissue using rolling circle amplification in combination with real-time PCR

(2011) Yanwei Zhong et al.   CLINICA CHIMICA ACTA

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Zinc-finger Nucleases as a Novel Therapeutic Strategy for Targeting Hepatitis B Virus DNAs

(2010) Thomas J Cradick et al.   MOLECULAR THERAPY

Hepatitis B Virus Resistance to Nucleos(t)ide Analogues

(2009) Fabien Zoulim et al.   GASTROENTEROLOGY

Understanding the molecular basis of HBV drug resistance by molecular modeling

(2008) A SHARON et al.   ANTIVIRAL RESEARCH

Hepatitis B Virus X Protein Increases the Cdt1-to-Geminin Ratio Inducing DNA Re-replication and Polyploidy

(2008) Lova Rakotomalala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis B Virus X Protein via the p38MAPK Pathway Induces E2F1 Release and ATR Kinase Activation Mediating p53 Apoptosis

(2008) Wen-Horng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY