Calpain-2 as a therapeutic target for acute neuronal injury

Protection against TBI-Induced Neuronal Death with Post-Treatment with a Selective Calpain-2 Inhibitor in Mice

(2018) Yubin Wang et al.   JOURNAL OF NEUROTRAUMA

Calpain-14 and its association with eosinophilic esophagitis

(2017) Vladislav A. Litosh et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Can ‘calpain-cathepsin hypothesis’ explain Alzheimer neuronal death?

(2016) Tetsumori Yamashima   AGEING RESEARCH REVIEWS

The autophagic lysosomal system in outflow pathway physiology and pathophysiology

(2016) Paloma B. Liton   EXPERIMENTAL EYE RESEARCH

Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression

(2016) T. Saito et al.   JOURNAL OF NEUROSCIENCE

Calpain research for drug discovery: challenges and potential

(2016) Yasuko Ono et al.   NATURE REVIEWS DRUG DISCOVERY

Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury

(2016) Yubin Wang et al.   NEUROBIOLOGY OF DISEASE

A calpain-2 selective inhibitor enhances learning & memory by prolonging ERK activation

(2016) Yan Liu et al.   NEUROPHARMACOLOGY

Calpain-1 and Calpain-2: The Yin and Yang of Synaptic Plasticity and Neurodegeneration

(2016) Michel Baudry et al.   TRENDS IN NEUROSCIENCES

Calpain 2-mediated autophagy defect increases susceptibility of fatty livers to ischemia–reperfusion injury

(2016) Q Zhao et al.   Cell Death & Disease

Accumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2

(2016) Yaling Yin et al.   Scientific Reports

Function and Mechanisms of Autophagy in Brain and Spinal Cord Trauma

(2015) Marta M. Lipinski et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of synaptic and nonsynaptic glutamate receptors in ischaemia induced neurotoxicity

(2015) A. Brassai et al.   BRAIN RESEARCH BULLETIN

Mitochondrial m-calpain opens the mitochondrial permeability transition pore in ischemia–reperfusion

(2015) Kaori Shintani-Ishida et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

ROS-Induced Nuclear Translocation of Calpain-2 Facilitates Cardiomyocyte Apoptosis in Tail-Suspended Rats

(2015) Hui Chang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Different Patterns of Electrical Activity Lead to Long-term Potentiation by Activating Different Intracellular Pathways

(2015) G. Zhu et al.   JOURNAL OF NEUROSCIENCE

Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors

(2015) Marton Siklos et al.   Acta Pharmaceutica Sinica B

Autophagy and apoptosis: where do they meet?

(2014) Subhadip Mukhopadhyay et al.   APOPTOSIS

Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness

(2014) Robert S.B. Clark et al.   Autophagy

Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury

(2014) Chinmoy Sarkar et al.   Autophagy

The role of calpain in an in vivo model of oxidative stress-induced retinal ganglion cell damage

(2014) Yu Yokoyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of calpains in traumatic brain injury

(2014) Shuang Liu et al.   BRAIN INJURY

Ischemic Stroke Injury Is Mediated by Aberrant Cdk5

(2014) D. A. Meyer et al.   JOURNAL OF NEUROSCIENCE

Degradation of βII-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions

(2014) Firas H. Kobeissy et al.   MOLECULAR NEUROBIOLOGY

Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders

(2014) Matthew P. Parsons et al.   NEURON

Organization, control and function of extrasynaptic NMDA receptors

(2014) T. Papouin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

(2014) Simin Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1  production in acute glaucoma

(2014) W. Chi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of autophagy and paraptosis in retinal ganglion cells after retinal ischemia and reperfusion injury in rats

(2014) TING WEI et al.   Experimental and Therapeutic Medicine

Characterization of the definitive classical calpain family of vertebrates using phylogenetic, evolutionary and expression analyses

(2014) D. J. Macqueen et al.   Open Biology

Targeting calpain in synaptic plasticity

(2013) Michel Baudry et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Calpain activation induced by glucose deprivation is mediated by oxidative stress and contributes to neuronal damage

(2013) Blanca Páramo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Brain injury-induced proteolysis is reduced in a novel calpastatin-overexpressing transgenic mouse

(2013) Kathleen M. Schoch et al.   JOURNAL OF NEUROCHEMISTRY

Calpain-2-Mediated PTEN Degradation Contributes to BDNF-Induced Stimulation of Dendritic Protein Synthesis

(2013) V. Briz et al.   JOURNAL OF NEUROSCIENCE

Distinct Roles for  -Calpain and m-Calpain in Synaptic NMDAR-Mediated Neuroprotection and Extrasynaptic NMDAR-Mediated Neurodegeneration

(2013) Y. Wang et al.   JOURNAL OF NEUROSCIENCE

Conditional Disruption of Calpain in the CNS Alters Dendrite Morphology, Impairs LTP, and Promotes Neuronal Survival following Injury

(2013) M. Amini et al.   JOURNAL OF NEUROSCIENCE

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Reconsider Alzheimer's disease by the ‘calpain–cathepsin hypothesis’—A perspective review

(2013) Tetsumori Yamashima   PROGRESS IN NEUROBIOLOGY

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

NMDA receptor subunits have different roles in NMDA-induced neurotoxicity in the retina

(2013) Ning Bai et al.   Molecular Brain

Evidence That the Blood Biomarker SNTF Predicts Brain Imaging Changes and Persistent Cognitive Dysfunction in Mild TBI Patients

(2013) Robert Siman et al.   Frontiers in Neurology

Dismantling the autophagic arsenal when it is time to die

(2012) Marco Corazzari et al.   Autophagy

Structure–function relationships in calpains

(2012) Robert L. Campbell et al.   BIOCHEMICAL JOURNAL

Regulation and physiological roles of the calpain system in muscular disorders

(2012) H. Sorimachi et al.   CARDIOVASCULAR RESEARCH

Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3)

(2012) J. Hubener et al.   HUMAN MOLECULAR GENETICS

Calpain and STriatal-Enriched protein tyrosine Phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model

(2012) C. M. Gladding et al.   HUMAN MOLECULAR GENETICS

Pharmacological analysis of the cortical neuronal cytoskeletal protective efficacy of the calpain inhibitor SNJ-1945 in a mouse traumatic brain injury model

(2012) Mona Bains et al.   JOURNAL OF NEUROCHEMISTRY

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

(2012) Cristian A. Lasagna-Reeves et al.   Scientific Reports

Calpain-5 Mutations Cause Autoimmune Uveitis, Retinal Neovascularization, and Photoreceptor Degeneration

(2012) Vinit B. Mahajan et al.   PLoS Genetics

The crosstalk between autophagy and apoptosis: where does this lead?

(2012) Claire Gordy et al.   Protein & Cell

Cyclin-Dependent Kinases in Brain Development and Disease

(2011) Susan C. Su et al.   Annual Review of Cell and Developmental Biology

Tau Oligomers as Potential Targets for Immunotherapy for Alzheimers Disease and Tauopathies

(2011) C. A. Lasagna-Reeves et al.   Current Alzheimer Research

Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in mice

(2011) C.-L. Luo et al.   NEUROSCIENCE

Activation of Autophagy in a Rat Model of Retinal Ischemia following High Intraocular Pressure

(2011) Antonio Piras et al.   PLoS One

Comparison of Dysferlin Expression in Human Skeletal Muscle with That in Monocytes for the Diagnosis of Dysferlin Myopathy

(2011) Eduard Gallardo et al.   PLoS One

The molecular basis of retinal ganglion cell death in glaucoma

(2011) Mohammadali Almasieh et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo

(2011) R Russo et al.   Cell Death & Disease

Control of basal autophagy by calpain1 mediated cleavage of ATG5

(2010) Hong-Guang Xia et al.   Autophagy

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Brain-Derived Neurotrophic Factor and Epidermal Growth Factor Activate Neuronal m-Calpain via Mitogen-Activated Protein Kinase-Dependent Phosphorylation

(2010) S. Zadran et al.   JOURNAL OF NEUROSCIENCE

αII-Spectrin Breakdown Products (SBDPs): Diagnosis and Outcome in Severe Traumatic Brain Injury Patients

(2010) Stefania Mondello et al.   JOURNAL OF NEUROTRAUMA

A Pharmacological Analysis of the Neuroprotective Efficacy of the Brain- and Cell-Permeable Calpain Inhibitor MDL-28170 in the Mouse Controlled Cortical Impact Traumatic Brain Injury Model

(2010) Stephanie N. Thompson et al.   JOURNAL OF NEUROTRAUMA

A novel calpastatin-based inhibitor improves postischemic neurological recovery

(2009) John Anagli et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Extrasynaptic NMDA Receptors Couple Preferentially to Excitotoxicity via Calpain-Mediated Cleavage of STEP

(2009) J. Xu et al.   JOURNAL OF NEUROSCIENCE

αII-Spectrin Breakdown Product Cerebrospinal Fluid Exposure Metrics Suggest Differences in Cellular Injury Mechanisms after Severe Traumatic Brain Injury

(2009) Gretchen M. Brophy et al.   JOURNAL OF NEUROTRAUMA

A Novel Calpain Inhibitor, ((1S)-1-((((1S)-1-Benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic Acid 5-Methoxy-3-oxapentyl Ester (SNJ-1945), Reduces Murine Retinal Cell Death In Vitro and In Vivo

(2009) M. Shimazawa et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cocrystal Structures of Primed Side-Extending α-Ketoamide Inhibitors Reveal Novel Calpain-Inhibitor Aromatic Interactions#

(2008) Jin Qian et al.   JOURNAL OF MEDICINAL CHEMISTRY

Knockdown of m-calpain increases survival of primary hippocampal neurons following NMDA excitotoxicity

(2008) Matthew B. Bevers et al.   JOURNAL OF NEUROCHEMISTRY

Calpain-Mediated Signaling Mechanisms in Neuronal Injury and Neurodegeneration

(2008) P. S. Vosler et al.   MOLECULAR NEUROBIOLOGY

Postsynaptic Density-95 (PSD-95) and Calcineurin Control the Sensitivity of N-Methyl-D-aspartate Receptors to Calpain Cleavage in Cortical Neurons

(2008) E. Y. Yuen et al.   MOLECULAR PHARMACOLOGY

Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin

(2008) Rachel A. Hanna et al.   NATURE

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

(2008) Andrea Williams et al.   Nature Chemical Biology

A novel calpain inhibitor, ((1S)-1((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl) carbamic acid 5-methoxy-3-oxapentyl ester, protects neuronal cells from cerebral ischemia-induced damage in mice

(2008) A. Koumura et al.   NEUROSCIENCE

Calpain in the CNS: From Synaptic Function to Neurotoxicity

(2008) J. Liu et al.   Science Signaling