Targeting calpain in synaptic plasticity

Massive expansion of the calpain gene family in unicellular eukaryotes

(2012) Sen Zhao et al.   BMC EVOLUTIONARY BIOLOGY

Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease

(2012) A. T. Simoes et al.   BRAIN

Neural functions of calcineurin in synaptic plasticity and memory

(2012) K. Baumgartel et al.   LEARNING & MEMORY

Calpain inhibitors: a survey of compounds reported in the patent and scientific literature

(2011) Isaac O Donkor   EXPERT OPINION ON THERAPEUTIC PATENTS

Calpains as potential anti-cancer targets

(2011) Ludovic Leloup et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Impact of genetic insights into calpain biology

(2011) Hiroyuki Sorimachi et al.   JOURNAL OF BIOCHEMISTRY

Calpain-mediated regulation of stargazin in adult rat brain

(2011) L. Yu et al.   NEUROSCIENCE

A novel strategy for therapeutic intervention for the genetic disease: Preventing proteolytic cleavage using small chemical compound

(2010) Masami Yamada et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of Adhesion Dynamics by Calpain-mediated Proteolysis of Focal Adhesion Kinase (FAK)

(2010) Keefe T. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain-Derived Neurotrophic Factor and Epidermal Growth Factor Activate Neuronal m-Calpain via Mitogen-Activated Protein Kinase-Dependent Phosphorylation

(2010) S. Zadran et al.   JOURNAL OF NEUROSCIENCE

Focal Adhesion Kinase Acts Downstream of EphB Receptors to Maintain Mature Dendritic Spines by Regulating Cofilin Activity

(2009) Y. Shi et al.   JOURNAL OF NEUROSCIENCE

Cofilin/ADF is required for retinal elongation and morphogenesis of the Drosophila rhabdomere

(2008) Hung Pham et al.   DEVELOPMENTAL BIOLOGY

Neurite consolidation is an active process requiring constant repression of protrusive activity

(2008) Ana Mingorance-Le Meur et al.   EMBO JOURNAL

Calpain activity contributes to the control of SNAP-25 levels in neurons

(2008) Carlotta Grumelli et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Calpain-Mediated Signaling Mechanisms in Neuronal Injury and Neurodegeneration

(2008) P. S. Vosler et al.   MOLECULAR NEUROBIOLOGY

Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin

(2008) Rachel A. Hanna et al.   NATURE

Cortactin branches out: Roles in regulating protrusive actin dynamics

(2008) Amanda Gatesman Ammer et al.   CELL MOTILITY AND THE CYTOSKELETON

Protein synthesis inhibition and memory: Formation vs amnesia

(2007) Paul E. Gold   NEUROBIOLOGY OF LEARNING AND MEMORY