Review
Biochemistry & Molecular Biology
Alice Jacquens, Edward J. Needham, Elisa R. Zanier, Vincent Degos, Pierre Gressens, David Menon
Summary: Head trauma is a common cause of disability in young adults, and cranial trauma in children has particularities in terms of epidemiology, mechanism, and physiopathology. The long-term repercussions of head trauma can be attributed to chronic neuroinflammation, a complex process involving various actors. Numerous studies have explored different anti-inflammatory therapies for traumatic brain injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Justin L. Krieg, Anna V. Leonard, Renee J. Turner, Frances Corrigan, Caroline Schnakers
Summary: Diffuse axonal injury (DAI) is a significant feature of traumatic brain injury (TBI), with different cytoskeletal components and temporal patterns. Accumulation of amyloid precursor protein (APP) is the most sensitive marker for axonal injury, but there are other types of axonal injury that cannot be detected using APP immunoreactivity. Recent research has identified the nodes of Ranvier and the axon initial segment as particularly vulnerable to axonal injury.
Article
Biochemistry & Molecular Biology
Zhihui Yang, Rawad Daniel Arja, Tian Zhu, George Anis Sarkis, Robert Logan Patterson, Pammela Romo, Disa S. Rathore, Ahmed Moghieb, Susan Abbatiello, Claudia S. Robertson, William E. Haskins, Firas Kobeissy, Kevin K. W. Wang
Summary: GFAP is truncated in traumatic brain injury, resulting in the formation of breakdown products. These GFAP breakdown products may have the potential to track the progression of brain injury, as shown in both experimental and clinical observations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Clement Delage, Toufik Taib, Celia Mamma, Dominique Lerouet, Valerie C. Besson
Summary: Traumatic brain injury (TBI) is a major cause of death and disability worldwide, leading to inflammatory responses, white matter injuries, and neurodegenerative pathologies. The consequences of TBI and pharmacological responses vary with age, emphasizing the need for age-specific approaches in therapy development.
Article
Anesthesiology
Federico Moro, Francesca Fossi, Aurora Magliocca, Rosaria Pascente, Eliana Sammali, Federico Baldini, Daniele Tolomeo, Edoardo Micotti, Giuseppe Citerio, Nino Stocchetti, Francesca Fumagalli, Sandra Magnoni, Roberto Latini, Giuseppe Ristagno, Elisa R. Zanier
Summary: In a mouse model, acute administration of argon gas (iAr) significantly accelerates sensorimotor recovery, improves cognitive deficits, and reduces white matter damage after TBI. iAr also decreases brain edema and neuroinflammation, while increasing ramified cells and the M2-like marker YM1 in microglia.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Clinical Neurology
Ouada Nebie, Kevin Carvalho, Lassina Barro, Liling Delila, Emilie Faivre, Ting-Yi Renn, Ming-Li Chou, Yu-Wen Wu, Ariunjargal Nyam-Erdene, Szu-Yi Chou, Luc Buee, Chaur-Jong Hu, Chih-Wei Peng, David Devos, David Blum, Thierry Burnouf
Summary: TBI causes significant brain anatomopathological damages which can be addressed by a synergistic biotherapy such as human platelet lysate. Its therapeutic potential was tested in in vitro and in vivo TBI models, showing promising results in improving motor function and mitigating neuroinflammation and oxidative stress. The data strongly support that human platelet lysate is a reliable and effective source of neurorestorative factors for brain trauma treatment.
Review
Chemistry, Medicinal
Julio J. Secades
Summary: Citicoline, a neuroprotective drug, has the potential to accelerate recovery of consciousness and improve the outcomes of patients with TBI. It could play a role in the management of TBI with its excellent safety profile.
Review
Biochemistry & Molecular Biology
David Gustafsson, Andrea Klang, Sebastian Thams, Elham Rostami
Summary: BDNF plays a crucial role in neural repair and regeneration, making it a focus of TBI research. Studies have shown varied effects on BDNF expression based on different experimental setups and interventions. Clinical research emphasizes the significance of BDNF polymorphism in outcomes, highlighting its protective role.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Chanon Srihagulang, Jirapong Vongsfak, Tanat Vaniyapong, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Traumatic Brain Injury (TBI) is a major cause of death and disability worldwide, characterized by immediate neuronal destruction and secondary brain injury mechanisms. Vagus nerve stimulation (VNS) shows potential for neuroprotection in TBI through various mechanisms, providing beneficial effects in animal models and patients. Further research is needed to fully understand the therapeutic potential of VNS in treating TBI.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Clinical Neurology
Daniel T. Laskowitz, David W. Van Wyck
Summary: The lack of targeted therapies for traumatic brain injury (TBI) is due to difficulties in animal modeling and clinical trial design. A reverse translational approach that focuses on translating endogenous mechanisms known to influence outcomes after TBI to develop druggable targets is proposed.
Article
Multidisciplinary Sciences
Ashfaq Ahmed Khan Malik, Waqas Ahmad, Farhan Younas, Haroon Badshah, Shatha Alharazy, Shafiq Ur Rehman, Muhammad Imran Naseer, Osama Yousef Muthaffar, Rehmatullah Achakzai, Ikram Ullah
Summary: Traumatic brain injury (TBI) is a major cause of mortality and a significant public health concern. This study investigated the neuroprotective effects of Troxerutin, a natural flavonoid, in a closed brain injury mouse model. The results demonstrated that pre-treatment with Troxerutin improved neurological functions, reduced brain edema, enhanced cognitive behavior, decreased Reactive Oxygen Species (ROS), and improved neuronal morphology and survival.
Article
Neurosciences
Jie Zhu, Xiaolong Lin, Chen Chen, Helian Tan, Yanping Gao, Di Li, Gang Chen
Summary: WNK3 is identified as a key regulator of chloride ion transport and neuronal survival in various cell types. The study revealed that overexpression of WNK3 ameliorated neuronal apoptosis, blood-brain barrier disruption, brain edema, and neurological deficits following traumatic brain injury, suggesting a potential neuroprotective role of WNK3 in TBI.
Article
Neurosciences
Xueshi Chen, Cheng Gao, Ya'nan Yan, Zhiqi Cheng, Guang Chen, Tongyu Rui, Chengliang Luo, Yuan Gao, Tao Wang, Xiping Chen, Luyang Tao
Summary: Traumatic brain injury (TBI) is a major global cause of death and disability, with various forms of cell death involved including ferroptosis. This study investigated the effect of the FDA approved drug ruxolitinib (Ruxo) on ferroptosis post-TBI, demonstrating its significant inhibitory effect on ferroptosis and neuroprotective effects on TBI-induced neurological deficits.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Neurosciences
Yu Liu, Zongren Zhao, Jianqiang Guo, Yuanhao Ma, Jing Li, Huanhuan Ji, Zhongjun Chen, Jinyu Zheng
Summary: The study found that anacardic acid has an anti-ferroptosis effect in traumatic brain injury, improving nerve function and cognitive impairment. Additionally, anacardic acid mitigated tissue defects, blood-brain barrier disruption, and neurodegeneration, while also displaying anti-inflammatory properties.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Marta Celorrio, James Rhodes, Sangeetha Vadivelu, McKenzie Davies, Stuart H. Friess
Summary: Preclinical trials testing the neuroprotective efficacy of N-acetylcysteine (NAC) against a secondary hypoxic insult after traumatic brain injury (TBI) demonstrated short and long-term neuropathological evidence of neuroprotection, but no detectable differences in long-term behavioral assessments between sham controls and injured mice were found.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Surgery
Patrick Stone, John Campbell, Stephanie Thompson, Jerri Walker
JOURNAL OF VASCULAR SURGERY
(2020)
Article
Surgery
Chelsea M. Knotts, Edward J. Prange, Krysta Orminski, Stephanie Thompson, Bryan K. Richmond
Article
Surgery
Shane Wylie Monnett, Jonathon Yu-Lin Tsai, Jeffrey Daniel Austin, Cameron Martin Harmon, Jacob Ian Shapiro, Lisa Christine Calderwood, Stephanie Thompson, Maria Alejandra Martinez, Edward Henry Tiley, Bryan Kelly Richmond, Jesse Allen Clanton
Article
Surgery
Robert W. Lightfoot, Caleb Thrash, Stephanie Thompson, Bryan K. Richmond
Summary: The optimal material for reinforcement of complex abdominal ventral hernia repair remains controversial. This study compared the outcomes of using porcine acellular dermal matrix (PADM) and bovine acellular dermal matrix (BADM) for open component separation ventral hernia repair. The results showed that BADM was associated with significantly fewer wound complications, lower recurrence rates, and fewer complications requiring reoperation. However, due to the small sample size, these differences did not reach statistical significance.
Article
Surgery
Chelsea Knotts, Alexandra Van Horn, Krysta Orminski, Stephanie Thompson, Jacob Minor, Michael Elmore, Bryan K. Richmond
Summary: This study examines the impact of demographics, comorbidities, frailty, and socioeconomic status on chemotherapy completion rates in colorectal cancer patients. The results show that comorbidities and frailty do not predict failure to complete chemotherapy, but age and insurance status are associated with chemotherapy completion rates.
Article
Surgery
Edward C. Tobin, Chelsea Knotts, Jonathon Tsai, Jeffrey Austin, Stephanie Thompson, Christina G. Attia, Bryan K. Richmond, Shane Monnett
Summary: Regardless of the technique used, rates of hiatal hernia occurrence at 5 years postoperatively did not differ significantly. In fact, avoiding closure of the crura was associated with fewer 30-day complications. The group that received closure with mesh reinforcement had the highest rate of 30-day complications.
Letter
Hematology
Batool El-Atoum, Gretchen Prather, Donna Arden, Stephanie Thompson, Steven Jubelirer, Mohamad Badawi, Ashley Meyer
Article
Surgery
Edward Charles Tobin, Nicholas Nolan, Stephanie Thompson, Michael Elmore, Bryan Kelly Richmond
Summary: Outcomes in colorectal cancer treatment are historically worse in Black people and residents of rural areas. This study found that the intersection of race and rural residence further worsens these outcomes.
Article
Obstetrics & Gynecology
Amee Amin, Marissa Frazie, Stephanie Thompson, Anjlee Patel
Summary: We evaluated the effectiveness of the Eat, Sleep, Console (ESC) model for neonatal abstinence syndrome at a regional referral center. Through retrospective analysis, we compared neonatal outcomes before and after the implementation of ESC model.
JOURNAL OF PERINATOLOGY
(2023)
Article
Surgery
Jacob Minor, Amy Wells, Krysta Orminski, Stephanie N. Thompson, Frank Annie, Lindsey Robinson, Byron C. Calhoun, Ramanathapura N. Haricharan
Summary: This study examined the incidence, risk factors, and spatial association of gastroschisis in a geographic region with known environmental pollution and hazardous waste sites. The results showed that gastroschisis was associated with younger maternal age, decreased pre-pregnancy BMI, and increased maternal tobacco use. Additionally, a potential geographic association was found between gastroschisis cases and EPA-designated hazardous waste sites.
Article
Public, Environmental & Occupational Health
Elham Alqudah, Amy Davis, Seher Berzingi, Katherine Webster, Stephanie Thompson, Cortney Evans, Kimberly Cross
Summary: This study aimed to identify factors associated with in-hospital formula supplementation in individuals who wanted to exclusively breastfeed. The results showed that certain maternal characteristics, such as high school level of education, primiparity, and Caesarean delivery, increased the risk of in-hospital formula supplementation.
MATERNAL AND CHILD HEALTH JOURNAL
(2023)
Article
Medicine, General & Internal
Anam Bashir, Raheel Khan, Stephanie Thompson, Manuel Caceres
Summary: Multiple studies have investigated the role of biomarkers in predicting pneumonia severity in adults but minimal conclusive research exists for children. This study aimed to determine if certain biomarkers collected within 72 hours of hospital arrival can predict the severity of community-associated pneumonia (CAP) in children. The results showed that elevated levels of CRP, PCT, and band counts were associated with increased pneumonia severity. PCT had the highest predictive value for moderate/severe CAP. Additionally, the study emphasized that clinical presentation should not be disregarded when assessing pneumonia severity.
Article
Oncology
Rahiya Rehman, Gabriel Solorzano, Rachel Heist, Stephanie N. Thompson, Mohamad Badawi
Meeting Abstract
Oncology
Rahiya Rehman, Gabriel Solorzano, Rachel Heist, Stephanie Thompson, Mohammad Badawi
PEDIATRIC BLOOD & CANCER
(2021)
Meeting Abstract
Oncology
Batool El-Atoum, Ryan Mitacek, Stephanie Thompson, Donna Arden, Gretchen Pfost, Steven Jubelirer, Mohamad Badawi, Ashley Meyer
PEDIATRIC BLOOD & CANCER
(2021)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)