Dupilumab for the treatment of asthma

Airway inflammation in asthma

(2016) Alex KleinJan   CURRENT OPINION IN PULMONARY MEDICINE

Asthma phenotypes and endotypes

(2016) Gwen S. Skloot   CURRENT OPINION IN PULMONARY MEDICINE

Interleukin-4 receptor signaling and its binding mechanism: A therapeutic insight from inhibitors tool box

(2016) Zaheer Ul-Haq et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Effect of Subcutaneous Dupilumab on Nasal Polyp Burden in Patients With Chronic Sinusitis and Nasal Polyposis

(2016) Claus Bachert et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Suppressor of Cytokine Signaling (SOCS)1 Regulates Interleukin-4 (IL-4)-activated Insulin Receptor Substrate (IRS)-2 Tyrosine Phosphorylation in Monocytes and Macrophages via the Proteasome

(2016) Sarah M. McCormick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial

(2016) Eugene R Bleecker et al.   LANCET

Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial

(2016) Sally Wenzel et al.   LANCET

Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial

(2016) J Mark FitzGerald et al.   LANCET

Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials

(2016) Nicola A Hanania et al.   Lancet Respiratory Medicine

Commentary: IL-4 and IL-13 receptors and signaling

(2015) Sarah M. McCormick et al.   CYTOKINE

IL-4 and IL-13 signaling in allergic airway disease

(2015) Naina Gour et al.   CYTOKINE

Targeting key proximal drivers of type 2 inflammation in disease

(2015) Namita A. Gandhi et al.   NATURE REVIEWS DRUG DISCOVERY

Group 2 innate lymphoid cells and asthma

(2015) Hiroki Kabata et al.   ALLERGOLOGY INTERNATIONAL

GATA-3 Function in Innate and Adaptive Immunity

(2014) Irma Tindemans et al.   IMMUNITY

Interleukin-13-induced activation of signal transducer and activator of transcription 6 is mediated by an activation of Janus kinase 1 in cultured human bronchial smooth muscle cells

(2014) Chiba Yoshihiko et al.   Pharmacological Reports

An IL-4/IL-13 Dual Antagonist Reduces Lung Inflammation, Airway Hyperresponsiveness, and IgE Production in Mice

(2013) Marion T. Kasaian et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

(2013) K. F. Chung et al.   EUROPEAN RESPIRATORY JOURNAL

‘All things considered’: transcriptional regulation of T helper type 2 cell differentiation from precursor to effector activation

(2013) Wei-ping Zeng   IMMUNOLOGY

Targeting eosinophils in allergy, inflammation and beyond

(2013) Patricia C. Fulkerson et al.   NATURE REVIEWS DRUG DISCOVERY

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dual targeting strategies with bispecific antibodies

(2012) Roland Kontermann   mAbs

IL-4 and IL-13 Dual Antagonism

(2010) Larry Borish   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Randomized, Controlled, Phase 2 Study of AMG 317, an IL-4Rα Antagonist, in Patients with Asthma

(2010) Jonathan Corren et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cytokine inhibition in severe asthma: current knowledge and future directions

(2010) Jonathan Corren   CURRENT OPINION IN PULMONARY MEDICINE

T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

(2009) Prescott G. Woodruff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Chronic inflammation and asthma

(2009) Jenna R. Murdoch et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The cytokine network in asthma and chronic obstructive pulmonary disease

(2008) Peter J. Barnes   JOURNAL OF CLINICAL INVESTIGATION

Type I IL-4Rs Selectively Activate IRS-2 to Induce Target Gene Expression in Macrophages

(2008) N. M. Heller et al.   Science Signaling

Untangling the Complex Web of IL-4- and IL-13-Mediated Signaling Pathways

(2008) M. Wills-Karp et al.   Science Signaling