Targeting key proximal drivers of type 2 inflammation in disease

Omalizumab for the treatment of chronic urticaria

(2015) Torsten Zuberbier et al.   Expert Review of Clinical Immunology

Efficacy and Safety of Omalizumab in Patients with Chronic Idiopathic/Spontaneous Urticaria who Remain Symptomatic on H 1 Antihistamines: A Randomized, Placebo-Controlled Study

(2015) Sarbjit S. Saini et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis

(2014) Jennifer D. Hamilton et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-33 Induces Antigen-Specific IL-5+ T Cells and Promotes Allergic-Induced Airway Inflammation Independent of IL-4

(2014) M. Kurowska-Stolarska et al.   JOURNAL OF IMMUNOLOGY

At the Bedside: The emergence of group 2 innate lymphoid cells in human disease

(2014) R. Stokes Peebles   JOURNAL OF LEUKOCYTE BIOLOGY

Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis

(2014) Lisa A. Beck et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

(2014) Hector G. Ortega et al.   NEW ENGLAND JOURNAL OF MEDICINE

Assessment of Pruritus Intensity: Prospective Study on Validity and Reliability of the Visual Analogue Scale, Numerical Rating Scale and Verbal Rating Scale in 471 Patients with Chronic Pruritus

(2013) N Phan et al.   ACTA DERMATO-VENEREOLOGICA

Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease

(2013) Steven J. Van Dyken et al.   Annual Review of Immunology

The effects of lebrikizumab in patients with mild asthma following whole lung allergen challenge

(2013) H. Scheerens et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids

(2013) Michael Noonan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

First-in-Human Study of REGN668/SAR231893 (IL-4Rα mAb): Safety, Tolerability and Biomarker Results of a Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study in Healthy Volunteers

(2013) Allen Radin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis

(2013) Mayte Suárez-Fariñas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Structural Basis of Signaling Blockade by Anti-IL-13 Antibody Lebrikizumab

(2013) Mark Ultsch et al.   JOURNAL OF MOLECULAR BIOLOGY

Omalizumab for the Treatment of Chronic Idiopathic or Spontaneous Urticaria

(2013) Marcus Maurer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

(2013) Sally Wenzel et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-4 Attenuates Th1-Associated Chemokine Expression and Th1 Trafficking to Inflamed Tissues and Limits Pathogen Clearance

(2013) Christopher A. Lazarski et al.   PLoS One

A global survey of changing patterns of food allergy burden in children

(2013) Susan L Prescott et al.   World Allergy Organization Journal

Targeting Interleukin-4 in Asthma: Lost in Translation?

(2012) Tania Maes et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Bronchoprovocation Testing in Asthma

(2012) Rohit K. Katial et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Progressive activation of TH2/TH22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis

(2012) Julia K. Gittler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma

(2012) Philippe Gevaert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

(2012) Ian D Pavord et al.   LANCET

Advances in Management of Atopic Dermatitis: New Therapies and Novel Uses of Existing Treatments

(2012) Elizabeth P. Chase et al.   SEMINARS IN CUTANEOUS MEDICINE AND SURGERY

State of the Art Treatment of Nasal Polyposis

(2011) Rony K. Aouad et al.   American Journal of Rhinology & Allergy

IL-13-induced MUC5AC production and goblet cell differentiation is steroid resistant in human airway cells

(2011) S. Kanoh et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Nonlesional atopic dermatitis skin is characterized by broad terminal differentiation defects and variable immune abnormalities

(2011) Mayte Suárez-Fariñas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mepolizumab, a humanized anti–IL-5 mAb, as a treatment option for severe nasal polyposis

(2011) Philippe Gevaert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Enteric-coated mycophenolate sodium versus cyclosporin A as long-term treatment in adult patients with severe atopic dermatitis: A randomized controlled trial

(2011) Inge M. Haeck et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Moderate correlation between quality of life and disease activity in adult patients with atopic dermatitis

(2011) I.M. Haeck et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Lebrikizumab Treatment in Adults with Asthma

(2011) Jonathan Corren et al.   NEW ENGLAND JOURNAL OF MEDICINE

Population PK and IgE Pharmacodynamic Analysis of a Fully Human Monoclonal Antibody Against IL4 Receptor

(2011) Tarundeep Kakkar et al.   PHARMACEUTICAL RESEARCH

A Randomized, Controlled, Phase 2 Study of AMG 317, an IL-4Rα Antagonist, in Patients with Asthma

(2010) Jonathan Corren et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effects of Interleukin-13 Blockade on Allergen-induced Airway Responses in Mild Atopic Asthma

(2010) Gail M. Gauvreau et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Direct Challenge Tests

(2010) Donald W. Cockcroft   CHEST

A review of treatment with mepolizumab, an anti–IL-5 mAb, in hypereosinophilic syndromes and asthma

(2010) William W. Busse et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Oral steroids and doxycycline: Two different approaches to treat nasal polyps

(2010) Thibaut Van Zele et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Thymic Stromal Lymphopoietin Promotes Lung Inflammation Through Activation of Dendritic Cells

(2010) Yan-Li Li et al.   JOURNAL OF ASTHMA

Efficacy and safety evaluation of ciclesonide in subjects with mild-to-moderate asthma not currently using inhaled corticosteroids

(2009) William E. Berger et al.   ALLERGY AND ASTHMA PROCEEDINGS

T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

(2009) Prescott G. Woodruff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program

(2009) Wendy C. Moore et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Emerging drugs for atopic dermatitis

(2009) Peck Y Ong   EXPERT OPINION ON EMERGING DRUGS

Inflammation in Chronic Rhinosinusitis and Nasal Polyposis

(2009) Cornelis M. van Drunen et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

IL-5- and eosinophil-mediated inflammation: from discovery to therapy

(2009) T. Kouro et al.   INTERNATIONAL IMMUNOLOGY

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

(2009) Pranabashis Haldar et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mepolizumab for Prednisone-Dependent Asthma with Sputum Eosinophilia

(2009) Parameswaran Nair et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cluster Analysis and Clinical Asthma Phenotypes

(2008) Pranab Haldar et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System

(2008) Sherry L. LaPorte et al.   CELL

Transgenic Expression of Interleukin-13 in the Skin Induces a Pruritic Dermatitis and Skin Remodeling

(2008) Tao Zheng et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Methods used in clinical development of novel anti-asthma therapies

(2008) Zuzana Diamant et al.   RESPIRATORY MEDICINE