Proton-sensing G protein-coupled receptors as regulators of cell proliferation and migration during tumor growth and wound healing

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

The Proton-Sensing G-Protein Coupled Receptor GPR4 Promotes Angiogenesis in Head and Neck Cancer

(2016) Zhibin Jing et al.   PLoS One

The pH-sensing receptor OGR1 improves barrier function of epithelial cells and inhibits migration in an acidic environment

(2015) Cheryl de Vallière et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy

(2015) Shari Pilon-Thomas et al.   CANCER RESEARCH

Impact of a Glycolic Acid-Containing pH 4 Water-in-Oil Emulsion on Skin pH

(2015) Barbara Behm et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

Involvement of acid-sensing ion channel 1α in hepatic carcinoma cell migration and invasion

(2015) Cheng Jin et al.   TUMOR BIOLOGY

Luminescent Dual Sensors Reveal Extracellular pH-Gradients and Hypoxia on Chronic Wounds That Disrupt Epidermal Repair

(2014) Stephan Schreml et al.   Theranostics

Regulation of inflammation by extracellular acidification and proton-sensing GPCRs

(2013) Fumikazu Okajima   CELLULAR SIGNALLING

Acidosis Decreases c-Myc Oncogene Expression in Human Lymphoma Cells: A Role for the Proton-Sensing G Protein-Coupled Receptor TDAG8

(2013) Zhigang Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acid-sensing ion channels in pain and disease

(2013) John A. Wemmie et al.   NATURE REVIEWS NEUROSCIENCE

Acidosis Activation of the Proton-Sensing GPR4 Receptor Stimulates Vascular Endothelial Cell Inflammatory Responses Revealed by Transcriptome Analysis

(2013) Lixue Dong et al.   PLoS One

Acidic tumor microenvironment and pH-sensing G protein-coupled receptors

(2013) Calvin R. Justus et al.   Frontiers in Physiology

pH sensing and regulation in cancer

(2013) Mehdi Damaghi et al.   Frontiers in Physiology

Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments

(2012) Jonathan W. Wojtkowiak et al.   CANCER RESEARCH

Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes

(2012) A. Calcinotto et al.   CANCER RESEARCH

Matrix metalloproteinases and epidermal wound repair

(2012) Vera L. Martins et al.   CELL AND TISSUE RESEARCH

Impact of Age and Body Site on Adult Female Skin Surface pH

(2012) Stephan Schreml et al.   DERMATOLOGY

Role of OGR1 in myeloid-derived cells in prostate cancer

(2012) L Yan et al.   ONCOGENE

Reduced pathological angiogenesis and tumor growth in mice lacking GPR4, a proton sensing receptor

(2011) Lorenza Wyder et al.   ANGIOGENESIS

Involvement of proton-sensing receptor TDAG8 in the anti-inflammatory actions of dexamethasone in peritoneal macrophages

(2011) Xiao-dong He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth muscle cells

(2011) Shinichi Matsuzaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The GPCR OGR1 (GPR68) mediates diverse signalling and contraction of airway smooth muscle in response to small reductions in extracellular pH

(2011) H Saxena et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of tumor cell migration and metastasis by the proton-sensing GPR4 receptor

(2011) Reid D. Castellone et al.   CANCER LETTERS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Interfering with pH regulation in tumours as a therapeutic strategy

(2011) Dario Neri et al.   NATURE REVIEWS DRUG DISCOVERY

Activation of GPR4 by Acidosis Increases Endothelial Cell Adhesion through the cAMP/Epac Pathway

(2011) Aishe Chen et al.   PLoS One

2D luminescence imaging of pH in vivo

(2011) S. Schreml et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Impact of 10% α-Hydroxy Acid Emulsion on Skin pH

(2011) S. Schreml et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

Episodic, transient systemic acidosis delays evolution of the malignant phenotype: Possible mechanism for cancer prevention by increased physical activity

(2010) Kieran Smallbone et al.   Biology Direct

The G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) facilitates tumor development by serving as an extracellular pH sensor

(2010) Y. Ihara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes

(2009) K. Dietl et al.   JOURNAL OF IMMUNOLOGY

Involvement of Proton-Sensing TDAG8 in Extracellular Acidification-Induced Inhibition of Proinflammatory Cytokine Production in Peritoneal Macrophages

(2009) C. Mogi et al.   JOURNAL OF IMMUNOLOGY

The impact of the pH value on skin integrity and cutaneous wound healing

(2009) S Schreml et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Abnormalities in Osteoclastogenesis and Decreased Tumorigenesis in Mice Deficient for Ovarian Cancer G Protein-Coupled Receptor 1

(2009) Hui Li et al.   PLoS One

G2A as a receptor for oxidized free fatty acids

(2008) Hideru Obinata et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

G2A Plays Proinflammatory Roles in Human Keratinocytes under Oxidative Stress as a Receptor for 9-Hydroxyoctadecadienoic Acid

(2007) Tomoyasu Hattori et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY