Article
Multidisciplinary Sciences
Min Wang, Lili Li, Jun Qian, Nannan Wang, Jun Bao, Jiangyue Lu, Faming Chen, Yanfen Li, Yangheng Zhang, Fuhua Yan
Summary: In this study, the salivary microbiota from patients with periodontitis was transferred to obese mice induced by high-fat diet to investigate the influence on gut microbiome and liver metabolism. The results showed that periodontitis salivary microbiota altered gut microbiota composition and exacerbated intestinal barrier dysfunction, leading to activation of toll-like receptor 4 signaling and release of pro-inflammatory factors in the liver. Moreover, the upregulation of the tryptophan-kynurenine-AhR signal axis in the liver was associated with aggravated hepatic steatosis and dysregulation of glucolipid metabolism during NAFLD development. This study suggests that periodontitis salivary microbiota may worsen the pathological progression of NAFLD in the context of obesity, with the tryptophan-AhR pathway potentially playing a key role.
Article
Nutrition & Dietetics
Roger Bentanachs, Laia Blanco, Maria Montesinos, Aleix Sala-Vila, Iolanda Lazaro, Jose Rodriguez-Morato, Rosa Maria Sanchez, Juan Carlos Laguna, Nuria Roglans, Marta Alegret
Summary: Non-alcoholic fatty liver disease is a sexual dimorphic disease, with different metabolic responses observed in female and male rats fed a high-fat high-fructose diet. In contrast to female rats, male rats showed increased adiposity and hyperleptinemia, but no hepatic steatosis, despite similar energy consumption.
Article
Nutrition & Dietetics
Danijela Ristic-Medic, Marijana Kovacic, Marija Takic, Aleksandra Arsic, Snjezana Petrovic, Marija Paunovic, Maja Jovicic, Vesna Vucic
Summary: This study evaluated the effects of calorie-restricted Mediterranean and low-fat diets on patients with NAFLD. Both diets resulted in significant weight loss and improvements in liver status and cardiometabolic markers. The Mediterranean diet may have additional benefits compared to the low-fat diet by improving fatty acid profiles and FLI in NAFLD patients.
Article
Medicine, Research & Experimental
Qing Zheng, Min Zhu, Xin Zeng, Wen Liu, Fudong Fu, Xiaoyu Li, Guangneng Liao, Yanrong Lu, Younan Chen
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease, and there is no effective treatment for its advanced stage, nonalcoholic steatohepatitis (NASH). This study compared and evaluated five different NAFLD mouse models, analyzing their characteristics and suitability for research and drug development. The high-fat diet (HFD) model showed early insulin resistance and mild liver steatosis, while the high-fat, high-fructose, and high-cholesterol diet (FFC) model exacerbated glucose and lipid metabolism disorders. The FFC combined with streptozotocin (STZ) model accelerated the pathologic process of NASH, and the STAM model showed the fastest formation of fibrosis nodules.
LABORATORY INVESTIGATION
(2023)
Article
Nutrition & Dietetics
Victoria Svop Jensen, Christian Fledelius, Erik Max Wulff, Jens Lykkesfeldt, Henning Hvid
Summary: The study demonstrates that hamsters rapidly develop dyslipidemia when fed a high-fat, high-fructose, high-cholesterol diet, and exhibit hepatic changes resembling human NAFLD within four to eight months on the NASH diet.
Article
Biochemistry & Molecular Biology
Junlin Zhang, Pu Yang, Hualin Wang, Qiang Huang, Ting Chen, Na Li, Hongyu Zhang, Zhiguo Liu
Summary: Excessive consumption of saturated fat leads to NAFLD, which can be alleviated by supplementation of n-3 PUFAs. The study demonstrated the crucial role of LOX-1 in HFD-induced ER stress, with potential implications for treating or preventing NAFLD.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Review
Cell Biology
Qiannan Ren, Qiming Sun, Junfen Fu
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely associated with a high-fat diet. Autophagy plays a protective role in NAFLD, but dysfunction of liver autophagy may contribute to the development of NAFLD.
Review
Pharmacology & Pharmacy
Linda Vanessa Marquez-Quiroga, Jaime Arellanes-Robledo, Veronica Rocio Vasquez-Garzon, Saul Villa-Trevino, Pablo Muriel
Summary: NASH is a major risk factor for HCC, and current experimental models provide valuable tools for studying and evaluating new drugs for chronic liver diseases. These models show promise in replicating liver alterations and promoting liver injury progression, but there is still room for improvement in simulating the progression from NASH to HCC.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ornella Selmin, Andreas J. Papoutsis, Sabine Hazan, Christopher Smith, Nick Greenfield, Micah G. Donovan, Spencer N. Wren, Thomas C. Doetschman, Justin M. Snider, Ashley J. Snider, Sherry H-H Chow, Donato F. Romagnolo
Summary: This study compared the effects of a typical Western diet and a soybean oil-rich n-6HFD on gut inflammation and microbiome using a mouse model. The results showed that n-6HFD induced colonic inflammation and altered gut bacterial composition, promoting the growth of proinflammatory bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Inaki Milton-Laskibar, Laura Judith Marcos-Zambrano, Saioa Gomez-Zorita, Alfredo Fernandez-Quintela, Enrique Carrillo de Santa Pau, J. Alfredo Martinez, Maria P. Portillo
Summary: The study analyzed and compared the metabolic effects of pterostilbene and resveratrol on gut microbiota composition in rats with NAFLD induced by a high-fat high-fructose diet. It found that the dramatic changes in gut microbiota induced by the diet were not significantly improved by pterostilbene or resveratrol.
Article
Engineering, Chemical
Yen-Peng Lee, Chien-Chao Chiu, Yi-Hsun Chen, Wen-Ching Huang, Yu-Chih Wang, Ching-Feng Chiu, Tien-Jen Lin, Shao-Wen Hung, Ju-Yun Liu, Hsiao-Li Chuang
Summary: A high-fructose diet can lead to metabolic syndrome, gut microbial dysbiosis, obesity, and nonalcoholic fatty liver disease (NAFLD). This study found that a single cefotaxime treatment could partially modify gut bacterial composition and affect the severity of fructose-induced NAFLD. Analysis of the treatment groups revealed that only the CF-FD group showed symptoms of obesity and NAFLD.
Article
Nutrition & Dietetics
Dou-Dou Li, Jia-Min Ma, Ming-Jing Li, Lu-Lu Gao, Yan-Na Fan, Yan-Nan Zhang, Xiu-Juan Tao, Jian-Jun Yang
Summary: This study investigated the effects of LBP, AE, and their combination on NASH. The results showed that LBP or AE reduced the severity of NASH, while the combination of LBP and AE more effectively improved liver damage and lowered levels of serum lipid and inflammation. Additionally, the combination also regulated genes involved in hepatic fatty acid synthesis and oxidation through the AMPK/PPARα/PGC-1α pathway, enhancing fatty acid oxidation.
Article
Biochemistry & Molecular Biology
Teruki Miyake, Shinya Furukawa, Bunzo Matsuura, Osamu Yoshida, Masumi Miyazaki, Akihito Shiomi, Sayaka Kanzaki, Hironobu Nakaguchi, Kotaro Sunago, Yoshiko Nakamura, Yusuke Imai, Takao Watanabe, Yasunori Yamamoto, Yohei Koizumi, Yoshio Tokumoto, Masashi Hirooka, Teru Kumagi, Masanori Abe, Yoichi Hiasa
Summary: The plasma fatty acid composition is associated with the histological evidence of nonalcoholic steatohepatitis (NASH). Increased synthesis of fatty acids is associated with NASH, while insufficient intake of n-3 essential fatty acids and reduced elongation of fatty acids are associated with fibrosis in NASH.
Article
Gastroenterology & Hepatology
Xuemei Gu, Rui Sun, Liang Chen, Shenghui Chu, Mark A. Doll, Xiaohong Li, Wenke Feng, Leah Siskind, Craig J. McClain, Zhongbin Deng
Summary: NcDase deficiency prevents hepatic inflammation and fibrosis in NASH, but not steatosis. It may regulate hepatic SCD1 expression and MUFAs synthesis through intestinal B cells, as well as alter gut microbiota composition, affecting liver lipid metabolism.
Article
Cell Biology
Jing-Hua Wang, Seung-Ju Hwang, Dong-Woo Lim, Chang-Gue Son
Summary: The ethanol extract of Cynanchum atratum (CAE) was found to have anti-fatty liver effects. A six-week treatment of CAE in mice on a high-fat, high-fructose diet significantly reduced body weight, liver weight, and mesenteric fat. CAE also improved blood parameters and liver damage, and normalized gene and protein expression related to liver lipid metabolism. Additionally, CAE decreased hepatic inflammation and fecal endotoxin levels, suggesting its potential for treating chronic metabolic diseases.