Expression and function of the metabotropic purinergic P2Y receptor family in experimental seizure models and patients with drug-refractory epilepsy

Spatiotemporal progression of ubiquitin-proteasome system inhibition after status epilepticus suggests protective adaptation against hippocampal injury

(2017) Tobias Engel et al.   Molecular Neurodegeneration

CADmutations and uridine-responsive epileptic encephalopathy

(2016) Johannes Koch et al.   BRAIN

ATPergic signalling during seizures and epilepsy

(2016) Tobias Engel et al.   NEUROPHARMACOLOGY

Purinergic receptors as potential therapeutic targets in Alzheimer's disease

(2016) Lucas T. Woods et al.   NEUROPHARMACOLOGY

A critical look at the function of the P2Y11 receptor

(2016) Karin Dreisig et al.   Purinergic Signalling

P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction

(2016) Segundo J. Guzman et al.   NEURAL PLASTICITY

ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y1 Purinergic Receptor via a YPX3L Motif

(2016) Michael R. Dores et al.   PLoS One

Enhanced astroglial Ca2+signaling increases excitatory synaptic strength in the epileptic brain

(2015) Carla Álvarez-Ferradas et al.   GLIA

Supportive or detrimental roles of P2Y receptors in brain pathology?—The two faces of P2Y receptors in stroke and neurodegeneration detected in neural cell and in animal model studies

(2015) Daniel Förster et al.   Purinergic Signalling

Epileptogenesis

(2015) Asla Pitkänen et al.   Cold Spring Harbor Perspectives in Medicine

Neuroprotection elicited by P2Y13 receptors against genotoxic stress by inducing DUSP2 expression and MAPK signaling recovery

(2014) Verónica Morente et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

P2Y receptors in Alzheimer's disease

(2014) Laurie Erb et al.   BIOLOGY OF THE CELL

P2Y1receptor inhibits GABA transport through a calcium signalling-dependent mechanism in rat cortical astrocytes

(2014) Pedro F. Jacob et al.   GLIA

Expression of Astrocyte-Related Receptors in Cortical Dysplasia With Intractable Epilepsy

(2014) Sayuri Sukigara et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuronal Hyperactivity Recruits Microglial Processes via Neuronal NMDA Receptors and Microglial P2Y12 Receptors after Status Epilepticus

(2014) U. B. Eyo et al.   JOURNAL OF NEUROSCIENCE

Nucleotide signalling during inflammation

(2014) Marco Idzko et al.   NATURE

Corticotropin-Releasing Factor Facilitates Epileptiform Activity in the Entorhinal Cortex: Roles of CRF2 Receptors and PKA Pathway

(2014) Lalitha Kurada et al.   PLoS One

CHOP regulates the p53–MDM2 axis and is required for neuronal survival after seizures

(2013) Tobias Engel et al.   BRAIN

Uridine modulates neuronal activity and inhibits spike-wave discharges of absence epileptic Long Evans and Wistar Albino Glaxo/Rijswijk rats

(2013) Zsolt Kovács et al.   BRAIN RESEARCH BULLETIN

The kainic acid model of temporal lobe epilepsy

(2013) Maxime Lévesque et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

(2012) Eva M Jimenez-Mateos et al.   NATURE MEDICINE

Adenosine dysfunction in epilepsy

(2011) Detlev Boison   GLIA

ERK1/2 activation is involved in the neuroprotective action of P2Y13 and P2X7 receptors against glutamate excitotoxicity in cerebellar granule neurons

(2011) Felipe Ortega et al.   NEUROPHARMACOLOGY

P2Y nucleotide receptors: promise of therapeutic applications

(2010) Kenneth A. Jacobson et al.   DRUG DISCOVERY TODAY

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

P2Y2 Receptor Transcription Is Increased by NF- B and Stimulates Cyclooxygenase-2 Expression and PGE2 Released by Intestinal Epithelial Cells

(2009) E. Degagne et al.   JOURNAL OF IMMUNOLOGY

Key factors in the discovery and development of new antiepileptic drugs

(2009) Meir Bialer et al.   NATURE REVIEWS DRUG DISCOVERY

Uracil nucleotides: From metabolic intermediates to neuroprotection and neuroinflammation

(2008) Davide Lecca et al.   BIOCHEMICAL PHARMACOLOGY

Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice

(2008) Genshin Mouri et al.   BRAIN RESEARCH

Deficits in Phosphorylation of GABAA Receptors by Intimately Associated Protein Kinase C Activity Underlie Compromised Synaptic Inhibition during Status Epilepticus

(2008) M. Terunuma et al.   JOURNAL OF NEUROSCIENCE

Status Epilepticus Induces a Particular Microglial Activation State Characterized by Enhanced Purinergic Signaling

(2008) E. Avignone et al.   JOURNAL OF NEUROSCIENCE

Modulation of neurotransmitter release by P2X and P2Y receptors in the rat spinal cord

(2007) Attila Heinrich et al.   NEUROPHARMACOLOGY