Review
Engineering, Environmental
Ashiq Ahamed, Lili Liang, Ming Yang Lee, Johan Bobacka, Grzegorz Lisak
Summary: Engineered nanomaterials (ENMs) are a novel class of materials with superior physicochemical properties compared to conventional materials, but can potentially release into the environment and pose toxic effects. Research focuses on the transformations and potential risks of ENMs in consumer products, aiming to ensure their safe application.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Xibo Lu, Zhuang Wang
Summary: This study investigated the potential ecological risk of a mixture of different nanostructured carbon nanotubes (CNTs) to zebrafish embryos. The results showed that the embryos were more resistant to mixed-type CNTs compared to single-type CNTs, but this resistance decreased in the presence of dissolved organic matter (DOM). The mixed-type CNTs increased the antioxidant capacity of the embryos but also caused oxidative damage. Transcriptome sequencing analysis revealed that the mixed-type CNTs significantly altered gene expression and affected cellular processes. DOM influenced the activation of the antioxidant defense system and gene expression.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Environmental Sciences
Hira Zafar, Rabia Javed, Muhammad Zia
Summary: Nanotechnology has been widely used in agricultural biotechnology due to its unique properties. However, the overuse of nanomaterials raises concerns about their fate and distribution in biological environments. Nanoparticles have both beneficial and adverse effects on plant health, leading to various eco-toxicological effects. This review article summarizes the factors, mechanisms, and risk assessment of the hazardous effects of nanoparticles on plants, and provides recommendations for designing safer nanomaterials for smarter agriculture.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Xiaoqiong Cao, Xiaoyong Pan, Sneha P. Couvillion, Tong Zhang, Carlos Tamez, Lisa M. Bramer, Jason C. White, Wei-Jun Qian, Brian D. Thrall, Kee Woei Ng, Xiao Hu, Philip Demokritou
Summary: The study investigated the fate of iron and copper-doped carbon dots during digestion, with higher dissolution rate observed for copper. Copper-doped carbon dots were found to induce a series of toxic effects, including decreased cell viability and alterations in metabolites.
Article
Biotechnology & Applied Microbiology
Samantha V. Llewellyn, Gillian E. Conway, Ilaria Zanoni, Amalie Kofoed Jorgensen, Ume-Kulsoom Shah, Didem Ag Seleci, Johannes G. Keller, Jeong Won Kim, Wendel Wohlleben, Keld Alstrup Jensen, Anna Costa, Gareth J. S. Jenkins, Martin J. D. Clift, Shareen H. Doak
Summary: This study found that acute exposure to five ENMs caused significant genotoxicity in liver spheroids, while prolonged exposure only resulted in genotoxicity at low concentrations of ZnO ENMs. There was no significant difference in toxicity outcomes between fractionated, repeated exposure and single, bolus exposure regimes in liver spheroids.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Environmental Sciences
Roshanak Tarrahi, Sepideh Mahjouri, Alireza Khataee
Summary: This article summarizes the results of toxicological studies on the interactions between NMs and plants, discussing the toxic mechanisms of NMs on plants and highlighting the various factors that influence the impact of NMs on plants. The importance of dose metrics for assessing toxicity and the need for standardized methodologies for accurate dose delivery of NMs to plants in the laboratory are emphasized.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Christopher A. W. David, M. Estela del Castillo Busto, Susana Cuello-Nunez, Heidi Goenaga-Infante, Michael Barrow, David G. Fernig, Patricia Murray, Matthew J. Rosseinsky, Andrew Owen, Neill J. Liptrott
Summary: Nanomaterials have the potential to interfere with autophagic processes, leading to altered cellular function and viability. The association of particle size with impact on autophagy warrants further investigation.
CELL AND BIOSCIENCE
(2021)
Article
Environmental Sciences
Jia-Bei Li, Wen-Song Xi, Shi-Ying Tan, Yuan-Yuan Liu, Hao Wu, Yuanfang Liu, Aoneng Cao, Haifang Wang
Summary: The study found that the commercial VO2 nanoparticle S-VO2 exhibited cytotoxicity and genotoxicity to HepG2 cells by inhibiting cell proliferation, leading to apoptosis and DNA damage. Additionally, S-VO2 also induced excessive ROS production, causing mitochondrial dysfunction, ATP synthesis interruption, and DNA damage, thereby inhibiting the proliferation of HepG2 cells.
Article
Nanoscience & Nanotechnology
Fatima Brandao, Carla Costa, Maria Joao Bessa, Vanessa Valdiglesias, Bryan Hellack, Andrea Haase, Sonia Fraga, Joao Paulo Teixeira
Summary: This study assessed the cytotoxicity and genotoxicity of different-sized and surface-modified amorphous silica nanomaterials on rat alveolar epithelial cells. The results showed that variants with larger surface areas had higher cytotoxic potential, SiO2_40 induced significant DNA damage, and all tested variants increased gamma-H2AX levels. This study supports the use of multiparametric approaches to improve understanding of nanomaterial mechanisms and hazard prediction.
Article
Environmental Sciences
Abraao Tiago Batista Guimaraes, Guilherme Malafaia
Summary: The study investigated the chronic effects of carbon nanofibers (CNFs) on juveniles of Podocnemis expansa (Amazon turtle) and found that CNFs uptake was associated with changes in REDOX systems, increased levels of antioxidants, and higher frequencies of erythrocyte abnormalities. Furthermore, the study revealed mutagenic, genotoxic, cytotoxic, and neurotoxic effects of CNFs on the turtles, reinforcing their toxic potential.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Chemistry, Multidisciplinary
Filipa Lebre, Nivedita Chatterjee, Samantha Costa, Eli Fernandez-de-Gortari, Carla Lopes, Joao Meneses, Luis Ortiz, Ana R. Ribeiro, Vania Vilas-Boas, Ernesto Alfaro-Moreno
Summary: The use of nanomaterials in various industries has raised concerns about their potential toxicity and risks. Nanosafety involves the use of existing toxicological approaches and the development of new approaches, such as nanotoxicology, to fully understand the potential toxicity and effects of nanomaterials. New technologies, like organs-on-chips and sophisticated sensors, are being developed to aid in this assessment. Life cycle assessment is also an important element in evaluating the overall environmental impact and sustainability of nanomaterials.
Article
Engineering, Environmental
Abraao Tiago Batista Guimaraes, Italo Nascimento Freitas, Nabisab Mujawar Mubarak, Md Mostafizur Rahman, Fernando Postalli Rodrigues, Aline Sueli de Lima Rodrigues, Damia Barcelo, Abu Reza Md Towfiqul Islam, Guilherme Malafaia
Summary: This study evaluated the impact of exposure to poly-styrene nanoparticles (PS NPs) on the behavior, brain antioxidant activity, and DNA damage in male Swiss mice. It was found that mice exposed to PS NPs exhibited anxiolytic-like behavior and altered defensive response when confronted with a predator. Additionally, the exposure to PS NPs led to reduced brain antioxidant activity and increased DNA damage. These findings highlight the potential impact of PS NPs on mammals and underscore the ecotoxicological risks associated with their dispersion in natural environments.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Andreya Goncalves Costa Motta, Vinicius Guerra, Diogo Ferreira do Amaral, Amanda Pereira da Costa Araujo, Lucelia Goncalves Vieira, Daniela de Melo e Silva, Thiago Lopes Rocha
Summary: This study investigated the effects of exposure to ZnO NPs and ZnCl2 at environmentally relevant concentrations on the morphology, chondrocranium, and behavior of tadpoles. The results showed that both forms of zinc altered the development of tadpoles, causing morphological changes and reduced individual fitness.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Izabela Koss-Mikolajczyk, Agnieszka Bartoszek
Summary: Numerous studies have shown that diets rich in anthocyanins have a wide range of health benefits. However, the structural differences between individual anthocyanidins significantly affect their antioxidant and biological activities. This study aimed to investigate the impact of structural differences on the six most common dietary anthocyanidins and found that the number and position of hydroxyl and methoxy groups strongly influenced their antioxidant and biological activities.
Review
Chemistry, Physical
Maha M. El-Kady, Iqbal Ansari, Charu Arora, Nidhi Rai, Sanju Soni, Dakeshwar Kumar Verma, Priyanka Singh, Alaa El Din Mahmoud
Summary: The present era is dominated by nanotechnology, where nanomaterials have gained significant importance in various fields due to their unique properties. These materials are classified based on their characteristics and their potential risks need to be investigated. This review critically examines the applications, behavior, and toxic impact of nanomaterials on humans, animals, and the environment. The review also addresses the challenges and future requirements for the development of safe nanotechnology for sustainable development.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Medicine, Research & Experimental
Babita Kaundal, Anup K. Srivastava, Atul Dev, Soni Jignesh Mohanbhai, Surajit Karmakar, Subhasree Roy Choudhury
MOLECULAR PHARMACEUTICS
(2020)
Article
Plant Sciences
Atul Dev, Mohammed Nadim Sardoiwala, Avinash Chandra Kushwaha, Surajit Karmakar, Subhasree Roy Choudhury
Summary: In this study, genistein nanoformulation was synthesized and shown to selectively induce apoptosis in oral squamous cell carcinoma by increasing reactive oxygen species and regulating epigenetic control-related proteins. Improved biodistribution and biocompatibility of the formulation were observed in vivo, suggesting potential therapeutic implications in the treatment of OSCC.
Article
Chemistry, Applied
Mohammed Nadim Sardoiwala, Surajit Karmakar, Subhasree Roy Choudhury
Summary: This study evaluates the neuroprotective potential of chitosan-based FTY720 nanoformulations for Parkinson's disease prevention by downregulating phosphorylated serine 129 (pSer129) alpha-Syn, showcasing its neuroprotective effects through anti-oxidative and anti-inflammatory mechanisms.
CARBOHYDRATE POLYMERS
(2021)
Article
Materials Science, Biomaterials
Jignesh Mohanbhai Soni, Mohammed Nadim Sardoiwala, Subhasree Roy Choudhury, Shyam Sunder Sharma, Surajit Karmakar
Summary: Inflammatory Bowel Disease (IBD) is a complex inflammatory condition caused by interactions of environmental and genetic factors, requiring potent anti-inflammatory drugs for treatment. Melatonin-loaded chitosan nanoparticles show promising anti-inflammatory effects, effectively reducing inflammatory markers and improving disease symptoms.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Chemistry, Physical
Anup K. Srivastava, Babita Kaundal, Mohammed Nadim Sardoiwala, Subhasree Roy Choudhury, Surajit Karmakar
Summary: A highly stable protein nanoparticle networked rare-earth metal carbonate-grafted bio-composite membrane was developed for selective removal of non-reactive phosphate pollutants. The membrane exhibited excellent phosphate adsorption capacity and non-enzymatic phosphatase-like activity, enabling effective removal of phosphate pollutants from the aquatic system and promoting the recovery of the ecosystem.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Materials Science, Biomaterials
Ankur Sood, Atul Dev, Mohammed Nadim Sardoiwala, Subhasree Roy Choudhury, Shubhra Chaturvedi, Anil Kumar Mishra, Surajit Karmakar
Summary: Targeting active mitochondria can overcome radioresistance in tumors, leading to improved efficacy in radiotherapy. Nanoparticles designed for active mitochondrial targeting show potential for enhancing radiosensitization in hepatocellular carcinoma, with efficient drug loading capabilities.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Materials Science, Biomaterials
Mohammed Nadim Sardoiwala, Soni Jignesh Mohanbhai, Surajit Karmakar, Subhasree Roy Choudhury
Summary: Parkinson's disease (PD) is a neurodegenerative disease caused by synucleinopathy. Recent studies have found that Hytrin can regulate energy homeostasis by activating the mitochondrial redox regulator IDH2, leading to attenuation of synucleinopathy in PD. However, the burst release kinetics of Hytrin restrict its therapeutic potential. Therefore, researchers aimed to improve Hytrin release kinetics through nanocarrier mediated delivery, and formulated Hytrin loaded polydopamine serotonin nanohybrid to replenish dopamine and serotonin for PD protection. The nanoformulation showed effective neurotherapeutic potential by improving Hytrin release profile and reducing PD symptoms. The neuroprotective effect was attributed to IDH2 induction and alpha-synuclein reduction, and the study revealed the direct physical interaction between IDH2 and alpha-synuclein, a hallmark of PD.
BIOMATERIALS ADVANCES
(2022)
Article
Nanoscience & Nanotechnology
Atul Dev, Mohammed Nadim Sardoiwala, Mrunalini Boddu, Soni Jignesh MohanBhai, Subhasree Roy Choudhury, Surajit Karmakar
Summary: This study successfully developed 4oxo-fenretinide-loaded human serum albumin nanoparticles and evaluated their therapeutic potential in treating neuroblastoma. The nanoparticles showed significant inhibitory effects on cancer cell proliferation and tumor growth, and demonstrated the ability to modulate histone epigenetic modifiers and inhibit epithelial mesenchymal transition. The study suggests that these nanoparticles could be a promising treatment option for neuroblastoma.
ACS APPLIED NANO MATERIALS
(2022)
Article
Medicine, Research & Experimental
Mohammed Nadim Sardoiwala, Soni Jignesh Mohanbhai, Avinash Chandra Kushwaha, Atul Dev, Liku Biswal, Shyam Sunder Sharma, Subhasree Roy Choudhury, Surajit Karmakar
Summary: Melatonin significantly improves clinical symptoms of inflammatory bowel disease by reducing EZH2 expression, indicating its potential as a therapeutic target. The study highlights how melatonin regulates epigenetics to alleviate symptoms of IBD.
Article
Chemistry, Medicinal
Atul Dev, Mohammed Nadim Sardoiwala, Angela Sharma, Soni Jignesh MohanBhai, Surajit Karmakar, Subhasree Roy Choudhury
Summary: Neuroblastoma is a pediatric tumor that is highly invasive and often metastasizes. Current treatment options are limited due to drug resistance and systemic toxicities. Researchers have developed a nanoformulation that delivers an acetyl pool and a chemotherapeutic drug to address these issues and successfully treat neuroblastoma in preclinical models.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Materials Science, Biomaterials
Avinash Chandra Kushwaha, Soni Jignesh Mohanbhai, Mohammed Nadim Sardoiwala, Mahendran Jaganathan, Surajit Karmakar, Subhasree Roy Choudhury
Summary: Osteoporosis is a metabolic bone disorder caused by an imbalance in bone remodeling. Genistein has been found to counteract osteoclastogenesis, but its usage is limited. This study utilised a nanoemulsified formulation of genistein with vitamin D to overcome these limitations and provide an efficient therapy for osteoporosis management.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Mohammed Nadim Sardoiwala, Ankur Sood, Liku Biswal, Subhasree Roy Choudhury, Surajit Karmakar
Summary: This study demonstrates the synthesis of magnetotransferrin by reconstituting apotransferrin to form iron oxide nanoparticles within the transferrin. The brain targeting potential of magnetotransferrin has been validated through in vivo/ex vivo imaging and immunogold staining of brain sections. This magnetic protein could be a potent candidate for brain targeting, bio-imaging, and therapy of neurological infirmities.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Biomaterials
Babita Kaundal, Surajit Karmakar, Subhasree Roy Choudhury
Summary: This study developed mitochondria-targeting nanoparticles for glioblastoma treatment, which modulated mitochondrial function and suppressed the expression of polycomb proteins to inhibit glioblastoma progression.
BIOMATERIALS SCIENCE
(2022)
Article
Materials Science, Biomaterials
Soni Jignesh Mohanbhai, Mohammed Nadim Sardoiwala, Shiwangi Gupta, Nishith Shrimali, Subhasree Roy Choudhury, Shyam Sunder Sharma, Prasenjit Guchhait, Surajit Karmakar
Summary: The study showed that colon targeted chitosan nanoparticles can enhance the anti-inflammatory effect of melatonin, indicating potential for UC treatment.
BIOMATERIALS ADVANCES
(2022)
