Insulin-like Growth Factor 1 Signaling Axis Meets p53 Genome Protection Pathways

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

(2015) Flore Kruiswijk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Can we unlock the potential of IGF-1R inhibition in cancer therapy?

(2014) Helen King et al.   CANCER TREATMENT REVIEWS

The Emerging Role of Insulin and Insulin-Like Growth Factor Signaling in Cancer Stem Cells

(2014) Roberta Malaguarnera et al.   Frontiers in Endocrinology

The association of TP53 mutations with the resistance of colorectal carcinoma to the insulin-like growth factor-1 receptor inhibitor picropodophyllin

(2013) Quan Wang et al.   BMC CANCER

p53 is required for brown adipogenic differentiation and has a protective role against diet-induced obesity

(2013) A Molchadsky et al.   CELL DEATH AND DIFFERENTIATION

IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination

(2013) M M Chitnis et al.   ONCOGENE

Growth hormone is a cellular senescence target in pituitary and nonpituitary cells

(2013) V. Chesnokova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin-like growth factor type 1 receptor (IGF-1R) exclusive nuclear staining: A predictive biomarker for IGF-1R monoclonal antibody (Ab) therapy in sarcomas

(2012) Irène Asmane et al.   EUROPEAN JOURNAL OF CANCER

The decline and fall of the IGF-I receptor

(2012) Renato Baserga   JOURNAL OF CELLULAR PHYSIOLOGY

IGF-1 and BRCA1 signalling pathways in familial cancer

(2012) Haim Werner et al.   LANCET ONCOLOGY

Insulin-like growth factors in the brain and their potential clinical implications

(2012) E. E. Benarroch   NEUROLOGY

Depletion of the type 1 IGF receptor delays repair of radiation-induced DNA double strand breaks

(2012) Benjamin W. Turney et al.   RADIOTHERAPY AND ONCOLOGY

Insulin receptor and cancer

(2011) A. Belfiore et al.   ENDOCRINE-RELATED CANCER

p53 Regulates insulin-like growth factor-I receptor gene expression in uterine serous carcinoma and predicts responsiveness to an insulin-like growth factor-I receptor-directed targeted therapy

(2011) Zohar Attias-Geva et al.   EUROPEAN JOURNAL OF CANCER

Tumor suppressors govern insulin-like growth factor signaling pathways: implications in metabolism and cancer

(2011) H Werner   ONCOGENE

The insulin-like growth factor-I receptor as an oncogene

(2011) Haim Werner et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Serial analysis of resected prostate cancer suggests up-regulation of type 1 IGF receptor with disease progression

(2010) Benjamin W. Turney et al.   BJU INTERNATIONAL

Type 1 Insulin-like Growth Factor Receptor Translocates to the Nucleus of Human Tumor Cells

(2010) T. Aleksic et al.   CANCER RESEARCH

Targeting insulin-like growth factor 1 receptor in sarcomas

(2010) Katia Scotlandi et al.   CURRENT OPINION IN ONCOLOGY

HMGA1 protein is a positive regulator of the insulin-like growth factor-I receptor gene

(2010) Aurora Aiello et al.   EUROPEAN JOURNAL OF CANCER

Progression to metastatic stage in a cellular model of prostate cancer is associated with methylation of the androgen receptor gene and transcriptional suppression of the insulin-like growth factor-I receptor gene

(2010) Hagit Schayek et al.   EXPERIMENTAL CELL RESEARCH

Differential regulation of insulin-like growth factor-I receptor gene expression by wild type and mutant androgen receptor in prostate cancer cells

(2010) Hagit Schayek et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Werner et al. Identification of Insulin-Like Growth Factor-I Receptor (IGF-IR) Gene Promoter-Binding Proteins in Estrogen Receptor (ER)-Positive and ER-Depleted Breast Cancer Cells

(2010) Rive Sarfstein et al.   Cancers

Mitochondrial localization of the low level p53 protein in proliferative cells

(2009) Ioana Ferecatu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting the IGF1 axis in cancer proliferation

(2009) Ilan Bruchim et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Transcription factor E2F1 is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene

(2009) Hagit Schayek et al.   GROWTH HORMONE & IGF RESEARCH

Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions

(2009) A Gualberto et al.   ONCOGENE

p53 Regulation of Metabolic Pathways

(2009) E. Gottlieb et al.   Cold Spring Harbor Perspectives in Biology

The Type 1 Insulin-Like Growth Factor Receptor Pathway

(2008) M. M. Chitnis et al.   CLINICAL CANCER RESEARCH

Insulin-Like Growth Factor-I Regulates Krüppel-Like Factor-6 Gene Expression in a p53-Dependent Manner

(2008) Itay Bentov et al.   ENDOCRINOLOGY

Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer

(2008) John SP Yuen et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Structural and Biochemical Studies of TIGAR (TP53-induced Glycolysis and Apoptosis Regulator)

(2008) Hua Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Similarities and differences between insulin and IGF-I: Structures, receptors, and signalling pathways

(2008) Haim Werner et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

IGF-1 Induces SREBP-1 Expression and Lipogenesis in SEB-1 Sebocytes via Activation of the Phosphoinositide 3-Kinase/Akt Pathway

(2007) Terry M. Smith et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY