IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination

Role of IGF-1 Receptor in Radiation Response

(2014) Almudena Valenciano et al.   Translational Oncology

Rb1 Haploinsufficiency Promotes Telomere Attrition and Radiation-Induced Genomic Instability

(2013) I. Gonzalez-Vasconcellos et al.   CANCER RESEARCH

IGF-1R Targeting Increases the Antitumor Effects of DNA-Damaging Agents in SCLC Model: An Opportunity to Increase the Efficacy of Standard Therapy

(2013) C. Ferte et al.   MOLECULAR CANCER THERAPEUTICS

Interlaboratory assessment of mitotic index by flow cytometry confirms superior reproducibility relative to microscopic scoring

(2012) D. J. Roberts et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Insulin-like Growth Factor Receptor Inhibitors: Baby or the Bathwater?

(2012) D. Yee   JNCI-Journal of the National Cancer Institute

Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition

(2012) A. Bielen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Depletion of the type 1 IGF receptor delays repair of radiation-induced DNA double strand breaks

(2012) Benjamin W. Turney et al.   RADIOTHERAPY AND ONCOLOGY

Akt: A Double-Edged Sword in Cell Proliferation and Genome Stability

(2012) Naihan Xu et al.   Journal of Oncology

Dual inhibition of epidermal growth factor and insulin-like 1 growth factor receptors reduce intestinal adenoma burden in the Apcmin/+ mouse

(2011) P H S Shaw et al.   BRITISH JOURNAL OF CANCER

Guidelines for preclinical and early phase clinical assessment of novel radiosensitisers

(2011) K J Harrington et al.   BRITISH JOURNAL OF CANCER

The apoptotic ring: A novel entity with phosphorylated histones H2AX and H2B, and activated DNA damage response kinases

(2011) Stéphanie Solier et al.   CELL CYCLE

γH2AX foci analysis for monitoring DNA double-strand break repair: Strengths, limitations and optimization

(2011) Markus Löbrich et al.   CELL CYCLE

PTEN Deletion in Prostate Cancer Cells Does Not Associate with Loss of RAD51 Function: Implications for Radiotherapy and Chemotherapy

(2011) M. Fraser et al.   CLINICAL CANCER RESEARCH

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

Insulin-Like Growth Factor–Type 1 Receptor Inhibitor NVP-AEW541 Enhances Radiosensitivity of PTEN Wild-Type but Not PTEN-Deficient Human Prostate Cancer Cells

(2011) Sofie F. Isebaert et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Insulin-like Growth Factor-I Receptor (IGF-IR) Translocates to Nucleus and AutoregulatesIGF-IRGene Expression in Breast Cancer Cells

(2011) Rive Sarfstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers

(2011) Siwanon Jirawatnotai et al.   NATURE

Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition

(2011) Neil Johnson et al.   NATURE MEDICINE

The insulin-like growth factor-I receptor inhibitor figitumumab (CP-751,871) in combination with docetaxel in patients with advanced solid tumours: results of a phase Ib dose-escalation, open-label study

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MDC1 Cleavage by Caspase-3: A Novel Mechanism for Inactivating the DNA Damage Response during Apoptosis

(2010) S. Solier et al.   CANCER RESEARCH

Type 1 Insulin-like Growth Factor Receptor Translocates to the Nucleus of Human Tumor Cells

(2010) T. Aleksic et al.   CANCER RESEARCH

IGFBP7 Is Not Required for B-RAF-Induced Melanocyte Senescence

(2010) Lyndee L. Scurr et al.   CELL

The Insulin-like Growth Factor I Receptor/Insulin Receptor Tyrosine Kinase Inhibitor PQIP Exhibits Enhanced Antitumor Effects in Combination with Chemotherapy Against Colorectal Cancer Models

(2010) S. A. Flanigan et al.   CLINICAL CANCER RESEARCH

High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines and Tumorgrafts Correlates with Sensitivity to Anti-IGF-IR Therapy

(2010) B. C. Litzenburger et al.   CLINICAL CANCER RESEARCH

Combination of Anti-IGF-1R Antibody A12 and Ionizing Radiation in Upper Respiratory Tract Cancers

(2010) Oliver Riesterer et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Therapy-Induced Senescence in Cancer

(2010) Jonathan A. Ewald et al.   JNCI-Journal of the National Cancer Institute

SUMOylation Mediates the Nuclear Translocation and Signaling of the IGF-1 Receptor

(2010) B. Sehat et al.   Science Signaling

Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair

(2009) E. Bolderson et al.   CLINICAL CANCER RESEARCH

Major Vault Protein May Affect Nonhomologous End-Joining Repair and Apoptosis Through Ku70/80 and BAX Downregulation in Cervical Carcinoma Tumors

(2009) Marta Lloret et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR

(2009) J. M. Carboni et al.   MOLECULAR CANCER THERAPEUTICS

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Insulin-like growth factor-1 attenuates cisplatin-induced γH2AX formation and DNA double-strand breaks repair pathway in non-small cell lung cancer

(2008) Jeong Hee Jeon et al.   CANCER LETTERS

Death through a tragedy: mitotic catastrophe

(2008) H Vakifahmetoglu et al.   CELL DEATH AND DIFFERENTIATION

Dual role of CDKs in DNA repair: To be, or not to be

(2008) Keiko Yata et al.   DNA REPAIR

Mitotic catastrophe and apoptosis induced by docetaxel in hormone-refractory prostate cancer cells

(2008) Francesco Fabbri et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

(2008) Aaron A. Goodarzi et al.   MOLECULAR CELL

Differential localization of MT1-MMP in human prostate cancer tissue: Role of IGF-1R in MT1-MMP expression

(2008) Isis C. Sroka et al.   PROSTATE

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics