Article
Multidisciplinary Sciences
Anna Mary Steitz, Clarissa Schroeder, Isabel Knuth, Corinna U. Keber, Leah Sommerfeld, Florian Finkernagel, Julia M. Jansen, Uwe Wagner, Sabine Muller-Bruesselbach, Thomas Worzfeld, Magdalena Huber, Vanessa M. Beutgen, Johannes Graumann, Elke Pogge von Strandmann, Rolf Mueller, Silke Reinartz
Summary: In ovarian high-grade serous carcinoma (HGSC), disruption of the protective peritoneal mesothelium is a crucial requirement for metastasis formation. This study discovered that tumor-associated NK cells induce TRAIL-dependent apoptosis in mesothelial cells via death receptors DR4 and DR5 when encountering activated T cells. The upregulation of TRAIL expression in NK cells and enhanced cytotoxicity towards mesothelial cells are primarily driven by T-cell-derived TNFa. Apoptotic mesothelial cells were found in the peritoneal fluid of HGSC patients, indicating a cooperative action of T and NK cells in breaching the mesothelial barrier.
Review
Biochemistry & Molecular Biology
You-Take Oh, Shi-Yong Sun
Summary: The involvement of the TRAIL/death receptor signaling pathway in the regulation of cancer invasion and metastasis is complex, with both positive and negative roles reported. The underlying molecular mechanisms are even more complicated. This review focuses on discussing the current understanding of how TRAIL/death receptor-mediated signaling regulates cancer cell invasion and metastasis.
Article
Oncology
Nagamani Vunnam, Malaney C. Young, Elly E. Liao, Chih Hung Lo, Evan Huber, MaryJane Been, David D. Thomas, Jonathan N. Sachs
Summary: Although nimesulide has been taken off the market due to hepatotoxicity, it is still used as a valuable research tool for developing new anticancer drugs. Several studies have been conducted to modify its structure and develop more potent anticancer agents. Understanding the mechanism of action for nimesulide is crucial in realizing its potential.
CANCER BIOLOGY & THERAPY
(2023)
Article
Oncology
K. M. A. Zinnah, Sang-Youel Park
Summary: The study demonstrated the mechanism behind the synergistic anticancer effect of amitriptyline and TRAIL, showing that amitriptyline increases TRAIL-induced apoptosis by upregulating death receptors DR4 and DR5. Inhibition of autophagy by amitriptyline was also shown to enhance DR4 and DR5 expression.
Article
Chemistry, Multidisciplinary
Michal Antoszczak, Sebastian Muller, Tatiana Caneque, Ludovic Colombeau, Nelson Dusetti, Patricia Santofimia-Castano, Christine Gaillet, Alain Puisieux, Juan Lucio Iovanna, Raphael Rodriguez
Summary: Persisting cancer cells are resistant to therapy and can adopt a drug-tolerant state through epithelial-mesenchymal plasticity. This study synthesized complex small molecule chimeras that accumulate in lysosomes and induce ferroptosis in drug-tolerant pancreatic cancer cells. The findings pave the way for the development of new cancer medicines targeting active ferroptosis.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Johannes Hoefle, Timo Trenkner, Nadja Kleist, Vera Schwane, Sarah Vollmers, Bryan Barcelona, Annika Niehrs, Pia Fittje, Van Hung Huynh-Tran, Juergen Sauter, Alexander H. Schmidt, Sven Peine, Angelique Hoelzemer, Laura Richert, Marcus Altfeld, Christian Koerner
Summary: TRAIL is identified to be involved in the recognition and activation of NK cells against HIV-1-infected cells. It induces degranulation and IFN-γ production, and its activation is not limited to its cognate death receptors but also involves decoy receptor I.
Article
Oncology
Min Huang, Cheng Yi, Xian-Zhou Huang, Juan Yan, Li-Jia Wei, Wei-Ju Tang, Shou-Chun Chen, Ying Huang
Summary: TRAIL-Mu3 exhibits stronger antitumor effects on pancreatic cancer cells compared with TRAIL by enhancing the apoptotic signaling pathway.
Review
Biochemistry & Molecular Biology
Longfei Deng, Xuan Zhai, Ping Liang, Hongjuan Cui
Summary: TRAIL holds therapeutic potential in cancer treatment, but many cancers, including GBM, exhibit resistance. Recent studies have identified new mechanisms in regulating TRAIL-induced apoptosis in GBM and effective combinatorial strategies. The TRAIL/TRAIL death receptor axis may have future clinical applications for GBM treatment.
Review
Pharmacology & Pharmacy
Adriana G. Quiroz-Reyes, Paulina Delgado-Gonzalez, Jose Francisco Islas, Juan Luis Delgado Gallegos, Javier Humberto Martinez Garza, Elsa N. Garza-Trevino
Summary: TRAIL is a promising strategy for tumor elimination, but cancer stem cells can easily develop evasion mechanisms for TRAIL-induced apoptosis.
Article
Environmental Sciences
Chun-Chen Huang, Yi-Ching Cheng, Ying-Chao Lin, Chun-Hung Chou, Chi-Tang Ho, Hao-Kuang Wang, Tzong-Der Way
Summary: The study showed that CSC-3436 could enhance TRAIL-induced apoptosis in TRAIL-resistant TNBC cells by down-regulating cell survival proteins and upregulating DR5 via the ROS-mediated upregulation of CHOP protein.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Xianzhou Huang, Haijun Li, Chunqing Ou, Yaqian Shu, Rui Luo, Xinchao Li, Shouchun Chen, Qinjie Wu, Changyang Gong, Lei Liu
Summary: The study demonstrates that a selfsustaining nanoplatform (SSN) can effectively reverse the downregulation of death receptors and remove blockage of XIAPs and survivin in TRAIL-resistant pancreatic cancer, providing a source-broadening and expenditure-reducing strategy to coactivate extrinsic and intrinsic apoptosis. This positive feedback loop not only broadens the source of death receptors but also reduces the expenditure of caspases by counteracting the inhibition of XIAPs and survivin, ultimately overcoming TRAIL-resistance in pancreatic cancer.
MATERIALS & DESIGN
(2021)
Article
Oncology
Khalid Rashid, Christian Roeder, Freya Goumas, Jan-Hendrik Egberts, Holger Kalthoff
Summary: In this study, the inhibition of CD95 signaling altered the chemotherapeutic effects of gemcitabine by suppressing the pro-inflammatory responses from CD95L-positive tumor cells as well as from the TNF-a and TRAIL signaling in a bi-lateral crosstalk manner.
Article
Biochemistry & Molecular Biology
Tomoya Fukuoka, Kenta Moriwaki, Shinji Takamatsu, Jumpei Kondo, Miki Tanaka-Okamoto, Azusa Tomioka, Manami Semba, Sachiko Komazawa-Sakon, Yoshihiro Kamada, Hiroyuki Kaji, Yasuhide Miyamoto, Masahiro Inoue, Kazuhiko Bessho, Yoko Miyoshi, Keiichi Ozono, Hiroyasu Nakano, Eiji Miyoshi
Summary: The study reveals that Lewis glycans positively regulate TRAIL-induced cell death, providing important insights into TRAIL sensitivity. Moreover, the expression of type I Lewis glycans is positively correlated with TRAIL sensitivity in colon cancer cell lines and patient-derived cancer organoids.
Article
Cell Biology
Emir Bozkurt, Heiko Dussmann, Manuela Salvucci, Brenton L. Cavanagh, Sandra Van Schaeybroeck, Daniel B. Longley, Seamus J. Martin, Jochen H. M. Prehn
Summary: The study reveals that TRAIL signaling not only activates apoptosis in colon cancer cells but also induces entosis through TRAIL receptors and the structural presence of caspase-8. The association of TRAIL signaling with cell-in-cell structures is significant in colorectal cancer, especially in the context of patient prognosis. Factors controlling entosis in tumors remain to be elucidated despite the evidence of entosis in cancers.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Guojun Zhang, Mingkai Xu, Xiaoqing Zhang, Ling Ma, Huiwen Zhang
Summary: SAM-1 can activate T cells and induce apoptosis in human tumor cells by regulating dendritic cell signaling pathways and cytokine production, mediated through TRAIL.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Review
Oncology
Elizabeth A. Repasky, Jason Eng, Bonnie L. Hylander
Article
Immunology
Nicholas D. Leigh, Kathleen M. Kokolus, Rachel E. O'Neill, Wei Du, Jason W. -L. Eng, Jingxin Qiu, George L. Chen, Philip L. McCarthy, J. David Farrar, Xuefang Cao, Elizabeth A. Repasky
JOURNAL OF IMMUNOLOGY
(2015)
Article
Multidisciplinary Sciences
Jason W. -L. Eng, Chelsey B. Reed, Kathleen M. Kokolus, Rosemarie Pitoniak, Adam Utley, Mark J. Bucsek, Wen Wee Ma, Elizabeth A. Repasky, Bonnie L. Hylander
NATURE COMMUNICATIONS
(2015)
Article
Biochemistry & Molecular Biology
Michelle N. Messmer, Kathleen M. Kokolus, Jason W. -L. Eng, Scott I. Abrams, Elizabeth A. Repasky
Review
Oncology
Jason W-L Eng, Kathleen M. Kokolus, Chelsey B. Reed, Bonnie L. Hylander, Wen W. Ma, Elizabeth A. Repasky
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2014)
Article
Biochemistry & Molecular Biology
Charles G. Pearce, Samer F. Najjar, Muneera R. Kapadia, Jozef Murar, Jason Eng, Brian Lyle, Oliver O. Aalami, Qun Jiang, Joseph A. Hrabie, Joseph E. Saavedra, Larry K. Keefer, Melina R. Kibbe
FREE RADICAL BIOLOGY AND MEDICINE
(2008)
Article
Oncology
Jason W. -L. Eng, Chelsey B. Reed, Kathleen M. Kokolus, Elizabeth A. Repasky
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2014)
Article
Surgery
Muneera R. Kapadia, Oliver O. Aalami, Samer F. Najjar, Qun Jiang, Jozef Murar, Brian Lyle, Jason W. Eng, Bonnie Kane, Timothy Carroll, Patricia M. Cahill, Melina R. Kibbe
JOURNAL OF SURGICAL RESEARCH
(2008)
Article
Surgery
Muneera R. Kapadia, Lesley W. Chow, Nick D. Tsihlis, Sadaf S. Ahanchi, Jason W. Hrabie, Jozef Murar, Janet Martinez, Daniel A. Popowich, Qun Jiang, Joseph A. Hrabie, Joseph E. Saavedra, Larry K. Keefer, James F. HUlvat, Samuel I. Stupp, Melina P. Kibbe
JOURNAL OF VASCULAR SURGERY
(2008)
Article
Biochemistry & Molecular Biology
Muneera R. Kapadia, Jason W. Eng, Qun Jiang, Detcho A. Stoyanovsky, Melina R. Kibbe
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2009)
Article
Multidisciplinary Sciences
Benjamin J. Povinelli, Kathleen M. Kokolus, Jason W. -L. Eng, Christopher W. Dougher, Leslie Curtin, Maegan L. Capitano, Christi T. Sailsbury-Ruf, Elizabeth A. Repasky, Michael J. Nemeth
Article
Multidisciplinary Sciences
Kathleen M. Kokolus, Maegan L. Capitano, Chen-Ting Lee, Jason W. -L. Eng, Jeremy D. Waight, Bonnie L. Hylander, Sandra Sexton, Chi-Chen Hong, Christopher J. Gordon, Scott I. Abrams, Elizabeth A. Repasky
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Oncology
Mark J. Bucsek, Guanxi Qiao, Cameron R. MacDonald, Thejaswini Giridharan, Lauren Evans, Brian Niedzwecki, Haichao Liu, Kathleen M. Kokolus, Jason W. -L. Eng, Michelle N. Messmer, Kristopher Attwood, Scott I. Abrams, Bonnie L. Hylander, Elizabeth A. Repasky
Article
Oncology
MA Bausero, A Bharti, DT Page, KD Perez, JWL Eng, SL Ordonez, EE Asea, C Jantschitsch, I Kindas-Muegge, D Ciocca, A Asea