CSC ‐3436 sensitizes triple negative breast cancer cells to TRAIL ‐induced apoptosis through ROS ‐mediated p38/ CHOP /death receptor 5 signaling pathways

Bufalin Induces Apoptotic Cell Death in Human Nasopharyngeal Carcinoma Cells through Mitochondrial ROS and TRAIL Pathways

(2019) En-Yun Su et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

RUNX3 enhances TRAIL-induced apoptosis by upregulating DR5 in colorectal cancer

(2019) Bo Ram Kim et al.   ONCOGENE

Auriculasin sensitizes primary prostate cancer cells to TRAIL-mediated apoptosis through up-regulation of the DR5-dependent pathway

(2019) Hyun-Dong Cho et al.   FOOD AND CHEMICAL TOXICOLOGY

Telmisartan generates ROS-dependent upregulation of death receptor 5 to sensitize TRAIL in lung cancer via inhibition of autophagy flux

(2018) Mohammad Rasheduzzaman et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Down-regulation of intracellular anti-apoptotic proteins, particularly c-FLIP by therapeutic agents; the novel view to overcome resistance to TRAIL

(2018) Ali Hassanzadeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

CSC-3436 inhibits TWIST-induced epithelial-mesenchymal transition via the suppression of Twist/Bmi1/Akt pathway in head and neck squamous cell carcinoma

(2018) Ying-Ju Lai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role of cellular reactive oxygen species in cancer chemotherapy

(2018) Haotian Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

DATS sensitizes glioma cells to TRAIL-mediated apoptosis by up-regulation of death receptor 5 via ROS

(2017) Jung Soon Hwang et al.   FOOD AND CHEMICAL TOXICOLOGY

Pterostilbene Enhances TRAIL-Induced Apoptosis through the Induction of Death Receptors and Downregulation of Cell Survival Proteins in TRAIL-Resistance Triple Negative Breast Cancer Cells

(2017) Chao-Ming Hung et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Plumbagin enhances TRAIL-induced apoptosis of human leukemic Kasumi-1 cells through upregulation of TRAIL death receptor expression, activation of caspase-8 and inhibition of cFLIP

(2017) Xiaoyang Kong et al.   ONCOLOGY REPORTS

Silibinin sensitizes TRAIL-mediated apoptosis by upregulating DR5 through ROS-induced endoplasmic reticulum stress-Ca2+-CaMKII-Sp1 pathway

(2017) Matharage Gayani Dilshara et al.   Oncotarget

Intracellular localization of DR5 and related regulatory pathways as a mechanism of resistance to TRAIL in cancer

(2016) Ufuk Mert et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1

(2015) Ling-Chu Chang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The alkyllysophospholipid edelfosine enhances TRAIL-mediated apoptosis in gastric cancer cells through death receptor 5 and the mitochondrial pathway

(2015) Sung-Chul Lim et al.   TUMOR BIOLOGY

Camptothecin sensitizes human hepatoma Hep3B cells to TRAIL-mediated apoptosis via ROS-dependent death receptor 5 upregulation with the involvement of MAPKs

(2014) Rajapaksha Gedara Prasad Tharanga Jayasooriya et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK–CHOP signaling pathways

(2014) Minh Truong Do et al.   FOOD AND CHEMICAL TOXICOLOGY

YM155 sensitizes triple-negative breast cancer to membrane-bound TRAIL through p38 MAPK- and CHOP-mediated DR5 upregulation

(2014) Marzia Pennati et al.   INTERNATIONAL JOURNAL OF CANCER

The TRAIL system is over-expressed in breast cancer and FLIP a marker of good prognosis

(2014) Gustav J. Ullenhag et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

CCT327 enhances TRAIL-induced apoptosis through the induction of death receptors and downregulation of cell survival proteins in TRAIL-resistant human leukemia cells

(2014) YAN-JIN LIU et al.   ONCOLOGY REPORTS

Emerging targeted therapies in triple-negative breast cancer

(2012) J. Crown et al.   ANNALS OF ONCOLOGY

Modulation of TRAIL resistance in colon carcinoma cells: Different contributions of DR4 and DR5

(2011) Caroline MM van Geelen et al.   BMC CANCER

Metabolic alterations in cancer cells and therapeutic implications

(2011) Naima Hammoudi et al.   Chinese Journal of Cancer

The coffee diterpene kahweol sensitizes TRAIL-induced apoptosis in renal carcinoma Caki cells through down-regulation of Bcl-2 and c-FLIP

(2010) Hee Jung Um et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

Hispidulin Sensitizes Human Ovarian Cancer Cells to TRAIL-Induced Apoptosis by AMPK Activation Leading to Mcl-1 Block in Translation

(2010) Jung-Mu Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Gossypol Induces Death Receptor-5 through Activation of the ROS-ERK-CHOP Pathway and Sensitizes Colon Cancer Cells to TRAIL

(2010) Bokyung Sung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERK/Ribosomal S6 Kinase (RSK) Signaling Positively Regulates Death Receptor 5 Expression through Co-activation of CHOP and Elk1

(2010) You-Take Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subtyping of Breast Cancer by Immunohistochemistry to Investigate a Relationship between Subtype and Short and Long Term Survival: A Collaborative Analysis of Data for 10,159 Cases from 12 Studies

(2010) Fiona M. Blows et al.   PLOS MEDICINE

LY303511 Enhances TRAIL Sensitivity of SHEP-1 Neuroblastoma Cells via Hydrogen Peroxide-Mediated Mitogen-Activated Protein Kinase Activation and Up-regulation of Death Receptors

(2009) K. Shenoy et al.   CANCER RESEARCH

Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC  -independent mechanism in human malignant tumor cells

(2008) J. H. Lim et al.   CARCINOGENESIS