Tumor-associated antigens: Tn antigen, sTn antigen, and T antigen

The Cosmc connection to the Tn antigen in cancer

(2017) Tongzhong Ju et al.   Cancer Biomarkers

Interactions of mucins with the Tn or Sialyl Tn cancer antigens including MUC1 are due to GalNAc–GalNAc interactions

(2016) Kristin E. Haugstad et al.   GLYCOBIOLOGY

The Role of Sialyl-Tn in Cancer

(2016) Jennifer Munkley   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Silencing of ST6GalNAc I suppresses the proliferation, migration and invasion of hepatocarcinoma cells through PI3K/AKT/NF-κB pathway

(2016) Xiao Yu et al.   TUMOR BIOLOGY

What controls the expression of the core-1 (Thomsen—Friedenreich) glycotope on tumor cells?

(2015) U. Karsten et al.   BIOCHEMISTRY-MOSCOW

Novel insights into the immunomodulatory role of the dendritic cell and macrophage-expressed C-type lectin MGL

(2015) Yvette van Kooyk et al.   IMMUNOBIOLOGY

Promoters of HumanCosmcandT-synthaseGenes Are Similar in Structure, Yet Different in Epigenetic Regulation

(2015) Junwei Zeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer

(2015) Bianca T. Hofmann et al.   Molecular Cancer

Glycan variation and evolution in the eukaryotes

(2015) Anthony P. Corfield et al.   TRENDS IN BIOCHEMICAL SCIENCES

Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation

(2015) Erandi Lira-Navarrete et al.   Nature Communications

The Breast Cancer-Associated Glycoforms of MUC1, MUC1-Tn and sialyl-Tn, Are Expressed in COSMC Wild-Type Cells and Bind the C-Type Lectin MGL

(2015) Richard Beatson et al.   PLoS One

GALNT2 suppresses malignant phenotypes through IGF-1 receptor and predicts favorable prognosis in neuroblastoma

(2015) Wan-Ling Ho et al.   Oncotarget

C1GALT1 overexpression promotes the invasive behavior of colon cancer cells through modifying O-glycosylation of FGFR2

(2015) Ji-Shiang Hung et al.   Oncotarget

Role of the polypeptide N-acetylgalactosaminyltransferase 3 in ovarian cancer progression: possible implications in abnormal mucin O-glycosylation

(2015) Zhi-Qiang Wang et al.   Oncotarget

OsteopontinO-glycosylation contributes to its phosphorylation and cell-adhesion properties

(2014) Yoshinobu Kariya et al.   BIOCHEMICAL JOURNAL

Preclinical studies with JAA-F11 anti-Thomsen-Friedenreich monoclonal antibody for human breast cancer

(2014) Kimiko Ferguson et al.   Future Oncology

RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells

(2014) Fumito Tamura et al.   Gastric Cancer

UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase from the snail Biomphalaria glabrata – substrate specificity and preference of glycosylation sites

(2014) Christopher Taus et al.   GLYCOCONJUGATE JOURNAL

Identification of a Novel Protein Binding Motif within the T-synthase for the Molecular Chaperone Cosmc

(2014) Rajindra P. Aryal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered Tumor-Cell Glycosylation Promotes Metastasis

(2014) Irina Häuselmann et al.   Frontiers in Oncology

Specific humoral immune response to the Thomsen-Friedenreich tumor antigen (CD176) in mice after vaccination with the commensal bacterium Bacteroides ovatus D-6

(2013) Philippe Ulsemer et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The development of synthetic antitumour vaccines from mucin glycopeptide antigens

(2013) Nikola Gaidzik et al.   CHEMICAL SOCIETY REVIEWS

Detection of breast cancer cells in blood samples by immunostaining of the Thomsen–Friedenreich antigen

(2013) Ulrich Andergassen et al.   Future Oncology

Human T Cell Activation Results in Extracellular Signal-regulated Kinase (ERK)-Calcineurin-dependent Exposure of Tn Antigen on the Cell Surface and Binding of the Macrophage Galactose-type Lectin (MGL)

(2013) Sandra J. van Vliet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The molecular chaperone cosmc enhances malignant behaviors of colon cancer cells via activation of Akt and ERK

(2013) John Huang et al.   MOLECULAR CARCINOGENESIS

A β-glucuronosyltransferase fromArabidopsis thalianainvolved in biosynthesis of type II arabinogalactan has a role in cell elongation during seedling growth

(2013) Eva Knoch et al.   PLANT JOURNAL

COSMC Is Overexpressed in Proliferating Infantile Hemangioma and Enhances Endothelial Cell Growth via VEGFR2

(2013) Jian-Jr Lee et al.   PLoS One

Primary Breast Cancer Tumours Contain High Amounts of IgA1 Immunoglobulin: An Immunohistochemical Analysis of a Possible Carrier of the Tumour-Associated Tn Antigen

(2013) Charlotte Welinder et al.   PLoS One

Enhancement of metastatic ability by ectopic expression of ST6GalNAcI on a gastric cancer cell line in a mouse model

(2012) Hidenori Ozaki et al.   CLINICAL & EXPERIMENTAL METASTASIS

Inhibition of metastatic tumor formation in vivo by a bacteriophage display-derived galectin-3 targeting peptide

(2012) Jessica R. Newton-Northup et al.   CLINICAL & EXPERIMENTAL METASTASIS

Detailed O-glycomics of the Muc2 mucin from colon of wild-type, core 1- and core 3-transferase-deficient mice highlights differences compared with human MUC2

(2012) Kristina A Thomsson et al.   GLYCOBIOLOGY

Mycophenolic acid reverses IgA1 aberrant glycosylation through up-regulating Cosmc expression in IgA nephropathy

(2012) Linshen Xie et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Knockdown of Core 1 Beta 1, 3-galactosyltransferase Prolongs Skin Allograft Survival with Induction of Galectin-1 Secretion and Suppression of CD8+T Cells

(2012) Hai-Dan Chen et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The Tn Antigen-Structural Simplicity and Biological Complexity

(2011) Tongzhong Ju et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Co-translational function of Cosmc, core 1 synthase specific molecular chaperone, revealed by a cell-free translation system

(2011) Yoshiki Narimatsu et al.   FEBS LETTERS

Control of mucin-type O-glycosylation: A classification of the polypeptide GalNAc-transferase gene family

(2011) E. P. Bennett et al.   GLYCOBIOLOGY

Differential glycosylation of MUC1 and CEACAM5 between normal mucosa and tumour tissue of colon cancer patients

(2011) Eirikur Saeland et al.   INTERNATIONAL JOURNAL OF CANCER

Phase III Multicenter Clinical Trial of the Sialyl-TN (STn)-Keyhole Limpet Hemocyanin (KLH) Vaccine for Metastatic Breast Cancer

(2011) D. Miles et al.   ONCOLOGIST

Structural Basis for Distinct Binding Properties of the Human Galectins to Thomsen-Friedenreich Antigen

(2011) Cheng-Feng Bian et al.   PLoS One

Cosmc is an essential chaperone for correct protein O-glycosylation

(2010) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sialyl-Tn vaccine induces antibody-mediated tumour protection in a relevant murine model

(2009) S Julien et al.   BRITISH JOURNAL OF CANCER

The Endoplasmic Reticulum Chaperone Cosmc Directly Promotesin VitroFolding of T-synthase

(2009) Rajindra P. Aryal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Tumor Antigens Tn and Sialyl Tn Arise from Mutations in Cosmc

(2008) T. Ju et al.   CANCER RESEARCH

Regulation of protein O-glycosylation by the endoplasmic reticulum–localized molecular chaperone Cosmc

(2008) Tongzhong Ju et al.   JOURNAL OF CELL BIOLOGY

Tumor immunolocalization using 124I-iodine-labeled JAA-F11 antibody to Thomsen–Friedenreich alpha-linked antigen

(2007) Richa Chaturvedi et al.   APPLIED RADIATION AND ISOTOPES