Article
Cell Biology
Ye Feng, Ying Xu, Yongjian Gao, Yiying Chen, Xuefeng Wang, Zhi Chen
Summary: SOX2OT is an up-regulated oncogene in CRC, promoting cell proliferation, migration, and invasion. It acts as a competing endogenous RNA to upregulate SOX5 by sponging miR-194-5p, thus affecting tumorgenesis of CRC.
CELL DEATH & DISEASE
(2021)
Article
Developmental Biology
Faying Liu, Zengming Li, Jiubai Guo, Shufen Fang, Jiangyan Zhou, Bianna Cao, Jun Liu, Yulan Yi, Xiaoqun Yuan, Xiaoyun Xu, Ouping Huang, Liqun Wang, Yang Zou
Summary: The study revealed that LASPI plays an important role in the pathogenesis of adenomyosis, with its overexpression enhancing the proliferative, migratory and invasive abilities of EcESCs, potentially related to DNA hypermethylation. Further investigation is needed to explore the detailed molecular mechanisms of LASPI upregulation in promoting cell proliferation, invasion and migration in adenomyosis. LASPI could serve as a prognostic biomarker for adenomyosis.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Immunology
Sen Zhang, Huangfu Hui, Qinli Zhao, Yujun Li, Lina Wu
Summary: This study revealed that the long noncoding RNA HCP5 is highly expressed in laryngeal squamous cell carcinoma (LSCC) and plays a role in promoting cancer cell growth, migration, and invasion. HCP5 interacts with miR-216a-5p, and its knockdown inhibits the malignant biological function of LSCC cells. Moreover, miR-216a-5p downregulates the expression of ZEB1, a target gene involved in LSCC progression. These findings suggest that targeting HCP5 may be a potential therapeutic strategy for LSCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Chun Li, Xin-You Pan, Mingyun Ma, Jun Zhao, Fengda Zhao, Ya-Ping Lv
Summary: In hepatocellular carcinoma, APS inhibits tumor growth, migration, and invasion by suppressing M2 polarization of TAMs.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Cell Biology
Lingwei Wang, Gang Liu, Enkhbat Bolor-Erdene, Qinchuan Li, Yunqing Mei, Lei Zhou
Summary: Esophageal squamous cell carcinoma (ESCC) is a common and aggressive tumor with poor long-term survival rates. Through gene expression analysis, KIF4A was found to be overexpressed in ESCC tissues and cells, associated with poor prognosis. KIF4A may serve as diagnostic and prognostic biomarkers and potential therapeutic targets in ESCC patients.
Article
Medicine, Research & Experimental
Xiaoting Huang, Leyang Xiang, Baiyao Wang, Jijie Hu, Chunshan Liu, Anbang Ren, Kunpeng Du, Gengtai Ye, Yingying Liang, Yunqiang Tang, Dinghua Yang, Yawei Yuan
Summary: This study demonstrates that CMTM6 plays a critical role in promoting proliferation, migration, and invasion in HCC through interacting with and stabilizing vimentin. The overexpression of CMTM6 is significantly associated with poor prognosis in HCC, suggesting its potential as a biomarker and therapeutic target for treating HCC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Tianshui Sun, Fangfang Bi, Zhuonan Liu, Qing Yang
Summary: In ovarian cancer patients, TMEM119 is overexpressed and associated with poor survival. Experimental results indicate TMEM119 promotes proliferation, invasion, and migration of ovarian cancer cells. Additionally, TMEM119 may exert oncogenic effects by regulating PDGFRB expression and activating the PI3K/AKT signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Huanhuan Deng, Leihong Deng, Haichao Chao, Zhaojun Yu, Jianbiao Huang, Zhen Song, Lifen Peng, Tao Zeng
Summary: Bladder cancer (BLCA) is a common cancer with high mortality ranking 9th. The relationship between autophagy and epithelial to mesenchymal transition (EMT) in BLCA is poorly understood. This study identified the autophagy-related gene RAB14 and demonstrated its promotion of EMT, migration, and invasion in bladder cancer cells through the Akt-associated autophagic pathway. Knocking down RAB14 inhibited EMT and autophagy in T24 cells, and RAB14 levels were positively correlated with key autophagy genes LC3B and Beclin1. These findings suggest the potential role of RAB14 in BLCA progression.
CELL DEATH DISCOVERY
(2023)
Article
Cell Biology
Zengpeng Chi, Qimin Wang, Lei Tong, Jing Qiu, Fang Yang, Qingyuan Guo, Wenjian Li, Jiawei Zheng, Zhenggang Chen
Summary: This study investigates the role and mechanism of Geranylgeranyltransferase type I (GGTase-I) in the malignant progression of salivary adenoid cystic carcinoma (SACC). The silencing of GGTase-I significantly reduces the migration, invasion, and proliferation of SACC cells. Additionally, GGTase-I may play a vital role in the migration and invasion of SACC by regulating the RhoA/ROCK1/MLC signaling pathway.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Cell Biology
Jun Huang, Qiuhua Yu, Yanjuan Zhou, Ying Chu, Feng Jiang, Qiang Wang
Summary: Our study demonstrated that FAM201A was significantly upregulated in LUAD tissues and cells, and its knockdown suppressed cell proliferation, migration, and invasion while promoting apoptosis. FAM201A was shown to affect LUAD progression by targeting miR-7515 to promote GLO1 expression. Additionally, FAM201A downregulation also suppressed LUAD development in vivo, indicating its potential as a novel therapeutic target for LUAD.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Oncology
Li Zhang, Xingyue Chen, Shun Yao, Liming Zheng, Xingyue Yang, Yongfeng Wang, Xin Li, Enqin Wu, Biguang Tuo
Summary: Chloride, as a major intracellular anion, plays a crucial role in maintaining ion homeostasis, osmotic pressure, and cell volume. Intracellular chloride channel 1 (CLIC1), besides its function as an ion channel, is involved in cell cycle regulation and intracellular oxidation. It has been found that CLIC1 is highly expressed in tumor cells and associated with malignancy and poor prognosis, suggesting its potential role in systemic diseases.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Chemistry, Medicinal
Beiwei Liang, Chunlai Li, Zhan Zhou, Yubo Xie
Summary: This study aimed to investigate the effect of hydromorphone on the growth of human gastric cancer cells. The results showed that within a certain concentration range, hydromorphone can suppress the growth of human gastric cancer cells, and the inhibitory effect is enhanced with longer incubation time and higher concentrations. Hydromorphone inhibits the growth of human gastric cancer cells through cell cycle arrest and induction of apoptosis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Oncology
Shitong Zhang, Xianhu Fu
Summary: The study explores the expression and mechanism of PCDH7 in cervical cancer and evaluates its clinical prognostic significance. PCDH7 is downregulated in cervical cancer tissues and cell lines, and its low expression is associated with a low survival rate. PCDH7 may be used as an independent prognostic factor for cervical cancer, impacting cancer cell proliferation, migration, and invasion.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Cell Biology
Mengna Zhang, Lingxian Zhang, Ajun Geng, Xiao Li, Yu Zhou, Liming Xu, Yi Arial Zeng, Jinpeng Li, Cheguo Cai
Summary: In this study, the researchers investigated the function of cyclin-dependent kinase 14 (CDK14) in mammary development and breast cancer progression. The results showed that CDK14 is expressed in mammary basal cells and elevated in triple negative breast cancer (TNBC). CDK14 knockdown or inhibition was found to suppress mammary regeneration and the progression of TNBC.
Article
Biotechnology & Applied Microbiology
Qisheng Su, Zheng Yang, Xiaobin Guo, Wuning Mo, Xiaohong Li
Summary: The study revealed that TPPP3 is significantly down-regulated in NPC tissues and cells, and its overexpression can inhibit cell proliferation and invasion ability, while having no significant effect on migration ability. Overexpression of TPPP3 also decreases the expression of MMP-2 and MMP-9 mRNA.