Fast functionalization of (7-aza)indoles using continuous flow processes

A review on recent developments of indole-containing antiviral agents

(2015) Ming-Zhi Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Continuous flow nitration in miniaturized devices

(2014) Amol A Kulkarni   Beilstein Journal of Organic Chemistry

Immobilized Transition Metals as Catalysts for Cross-Couplings in Continuous Flow-A Critical Assessment of the Reaction Mechanism and Metal Leaching

(2014) David Cantillo et al.   ChemCatChem

Synthesis of Some Novel 3-Substituted Indole Derivatives Using Polyamine Functionalized Heterogeneous Catalyst

(2014) Rupali L. Magar et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

The Azaindole Framework in the Design of Kinase Inhibitors

(2014) Jean-Yves Mérour et al.   MOLECULES

Synthesis of Isatins by I2/TBHP Mediated Oxidation of Indoles

(2014) You Zi et al.   ORGANIC LETTERS

Process Intensification of the Suzuki–Miyaura Reaction over Sol–Gel Entrapped Catalyst SiliaCat DPP-Pd Under Conditions of Continuous Flow

(2014) Valerica Pandarus et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Robust and reusable supported palladium catalysts for cross-coupling reactions in flow

(2014) William R. Reynolds et al.   Catalysis Science & Technology

Sonogashira cross-coupling under non-basic conditions. Flow chemistry as a new paradigm in reaction control

(2014) Svatava Voltrova et al.   Organic Chemistry Frontiers

Highly regioselective synthesis of 2,4,5-(hetero)aryl substituted oxazoles by intermolecular [3+2]-cycloaddition of unsymmetrical internal alkynes

(2013) Elli Chatzopoulou et al.   CHEMICAL COMMUNICATIONS

One-Pot Synthesis of Camalexins and 3,3′-Biindoles by the Masuda Borylation-Suzuki Arylation (MBSA) Sequence

(2013) Boris O. A. Tasch et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Discovery, Synthesis, and Characterization of an Orally Bioavailable, Brain Penetrant Inhibitor of Mixed Lineage Kinase 3

(2013) Val S. Goodfellow et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in the synthesis and properties of 4-, 5-, 6- or 7-azaindoles

(2013) Jean-Yves Mérour et al.   TETRAHEDRON

Building a Sulfonamide Library by Eco-Friendly Flow Synthesis

(2013) Antimo Gioiello et al.   ACS Combinatorial Science

In Situ Anionic Shielding for Regioselective Metalation: Directed peri and Iterative Metalation Routes to Polyfunctionalized 7-Azaindoles

(2012) Cédric Schneider et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous Flow Synthesis. A Pharma Perspective

(2012) Laia Malet-Sanz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Continuous Flow Sonogashira C–C Coupling Using a Heterogeneous Palladium–Copper Dual Reactor

(2012) Li-Min Tan et al.   ORGANIC LETTERS

Mixing and Dispersion in Small-Scale Flow Systems

(2012) Kevin D. Nagy et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Ten key issues in modern flow chemistry

(2011) Jens Wegner et al.   CHEMICAL COMMUNICATIONS

Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents

(2011) Pamela Kassis et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

One-Pot Synthesis of Diazine-Bridged Bisindoles and Concise Synthesis of the Marine Alkaloid Hyrtinadine A

(2011) Boris O. A. Tasch et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Continuous flow reactors: a perspective

(2011) Charlotte Wiles et al.   GREEN CHEMISTRY

Microfluidic Mixing: A Review

(2011) Chia-Yen Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regioselective dibromination of methyl indole-3-carboxylate and application in the synthesis of 5,6-dibromoindoles

(2011) Thomas B. Parsons et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Rapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling–TMS-deprotection–CuAAC sequence

(2011) Eugen Merkul et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Suzuki–Miyaura Cross-Coupling of Heteroaryl Halides and Arylboronic Acids in Continuous Flow

(2011) Timothy Noël et al.   ORGANIC LETTERS

Continuous Flow Processing of Slurries: Evaluation of an Agitated Cell Reactor

(2011) Duncan L. Browne et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Indole synthesis: a review and proposed classification

(2011) Douglass F. Taber et al.   TETRAHEDRON

Synthesis and biological evaluation of 2,3-bis(het)aryl-4-azaindole derivatives as protein kinase inhibitors

(2011) Frédéric Pin et al.   MedChemComm

Synthesis and biological activities of new furo[3,4-b]carbazoles: Potential topoisomerase II inhibitors

(2010) Youssef Hajbi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The flow synthesis of heterocycles for natural product and medicinal chemistry applications

(2010) Marcus Baumann et al.   MOLECULAR DIVERSITY

Silica-supported palladium: Sustainable catalysts for cross-coupling reactions

(2009) Vivek Polshettiwar et al.   COORDINATION CHEMISTRY REVIEWS

Highly Substituted Indole Library Synthesis by Palladium-Catalyzed Coupling Reactions in Solution and on a Solid Support

(2009) Shilpa A. Worlikar et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Convenient access to C-2 or C-5 substituted 4-azaindole derivatives

(2009) Fabienne Saab et al.   TETRAHEDRON

Novel 5-azaindolocarbazoles as cytotoxic agents and Chk1 inhibitors

(2008) Myriam Lefoix et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Amino-Zinc-Ene-Enolate Cyclization: A Short Access tocis-3-Substituted Prolino-homotryptophane Derivatives

(2008) Céline Mothes et al.   JOURNAL OF ORGANIC CHEMISTRY

High-Efficiency Aminocarbonylation by Introducing CO to a Pressurized Continuous Flow Reactor

(2008) Csaba Csajági et al.   ORGANIC LETTERS