The Hygiene Hypothesis and Its Inconvenient Truths about Helminth Infections

Multiple Exposures to Ascaris suum Induce Tissue Injury and Mixed Th2/Th17 Immune Response in Mice

(2016) Denise Silva Nogueira et al.   PLoS Neglected Tropical Diseases

Human helminth therapy to treat inflammatory disorders- where do we stand?

(2015) Helena Helmby   BMC IMMUNOLOGY

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

(2015) Roni Nowarski et al.   CELL

IgE responses toAscarisand mite tropomyosins are risk factors for asthma

(2015) V. Ahumada et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Experimental hookworm infection and gluten microchallenge promote tolerance in celiac disease

(2015) John Croese et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Innate immunological function of TH2 cells in vivo

(2015) Liying Guo et al.   NATURE IMMUNOLOGY

Worm Infections in Children

(2015) J. E. Weatherhead et al.   PEDIATRICS IN REVIEW

Can Helminth Infection Reverse Microbial Dysbiosis?

(2015) P’ng Loke et al.   TRENDS IN PARASITOLOGY

The IgE response to Ascaris molecular components is associated with clinical indicators of asthma severity

(2015) Emiro Buendía et al.   World Allergy Organization Journal

Asthma and toxocariasis

(2014) Lingling Li et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Advancing a multivalent ‘Pan-anthelmintic’ vaccine against soil-transmitted nematode infections

(2014) Bin Zhan et al.   Expert Review of Vaccines

Cohort Profile: The Ecuador Life (ECUAVIDA) study in Esmeraldas Province, Ecuador

(2014) Philip J Cooper et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Goblet Cell-Derived Resistin-Like Molecule   Augments CD4+ T Cell Production of IFN-  and Infection-Induced Intestinal Inflammation

(2014) M. G. Nair et al.   JOURNAL OF IMMUNOLOGY

Helminth Infections Decrease Host Susceptibility to Immune-Mediated Diseases

(2014) Joel V. Weinstock et al.   JOURNAL OF IMMUNOLOGY

Helminth therapy or elimination: epidemiological, immunological, and clinical considerations

(2014) Linda J Wammes et al.   LANCET INFECTIOUS DISEASES

Helminths in the lungs

(2014) J. M. Craig et al.   PARASITE IMMUNOLOGY

Global numbers of infection and disease burden of soil transmitted helminth infections in 2010

(2014) Rachel L Pullan et al.   Parasites & Vectors

The "hygiene hypothesis" for allergic disease is a misnomer

(2014) W. Parker   BMJ-British Medical Journal

The Global Burden of Disease Study 2010: Interpretation and Implications for the Neglected Tropical Diseases

(2014) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases

Toxocariasis in North America: A Systematic Review

(2014) Rachel M. Lee et al.   PLoS Neglected Tropical Diseases

Randomised clinical trial: the safety and tolerability ofTrichuris suisova in patients with Crohn's disease

(2013) W. J. Sandborn et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Genetic analysis of the Trichuris muris-induced model of colitis reveals QTL overlap and a novel gene cluster for establishing colonic inflammation

(2013) Scott E Levison et al.   BMC GENOMICS

Parasitological and immunological aspects of early Ascaris spp. infection in mice

(2013) Pedro Henrique Gazzinelli-Guimarães et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Helminth Infections

(2013) Peter Hotez et al.   OBSTETRICS AND GYNECOLOGY

A fresh look at the hygiene hypothesis: How intestinal microbial exposure drives immune effector responses in atopic disease

(2013) Eric M. Brown et al.   SEMINARS IN IMMUNOLOGY

Soil-Transmitted Helminthiasis in the United States: A Systematic Review—1940–2010

(2011) Michelle C. Starr et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

Probiotic helminth administration in relapsing–remitting multiple sclerosis: a phase 1 study

(2011) JO Fleming et al.   Multiple Sclerosis Journal

Suppression of Inflammatory Immune Responses in Celiac Disease by Experimental Hookworm Infection

(2011) Henry J. McSorley et al.   PLoS One

Experimental hookworm infection: a randomized placebo-controlled trial in asthma

(2010) J. R. Feary et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update

(2010) H. Okada et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Mucin Gene Deficiency in Mice Impairs Host Resistance to an Enteric Parasitic Infection

(2010) Sumaira Z. Hasnain et al.   GASTROENTEROLOGY

Chronic Intestinal Helminth Infections Are Associated with Immune Hyporesponsiveness and Induction of a Regulatory Network

(2010) C. A. Figueiredo et al.   INFECTION AND IMMUNITY

Colonic transcriptional profiling in resistance and susceptibility to trichuriasis

(2010) S. E. Levison et al.   INFLAMMATORY BOWEL DISEASES

Estimating the global distribution and disease burden of intestinal nematode infections: Adding up the numbers – A review

(2010) Simon Brooker   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Toxocara infection and diminished lung function in a nationally representative sample from the United States population

(2010) Michael G. Walsh   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Association of atopy, asthma, allergic rhinoconjunctivitis, atopic dermatitis and intestinal helminth infections in Cuban children

(2010) Meike Wördemann et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Safety of hookworm infection in individuals with measurable airway responsiveness: a randomized placebo-controlled feasibility study

(2009) J. Feary et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Trichuris suis ova therapy for allergic rhinitis: A randomized, double-blind, placebo-controlled clinical trial

(2009) Peter Bager et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rescuing the bottom billion through control of neglected tropical diseases

(2009) Peter J Hotez et al.   LANCET

Helminths and our immune system: Friend or foe?

(2009) Helena Helmby   PARASITOLOGY INTERNATIONAL

Toxocariasis: America's Most Common Neglected Infection of Poverty and a Helminthiasis of Global Importance?

(2009) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases