Article
Biochemistry & Molecular Biology
Lawrence E. Ostrowski, Weining Yin, Amanda J. Smith, Patrick R. Sears, Ximena M. Bustamante-Marin, Hong Dang, Friedhelm Hildebrandt, Leigh Anne Daniels, Nicole A. Capps, Kelli M. Sullivan, Margaret W. Leigh, Maimoona A. Zariwala, Michael R. Knowles
Summary: Primary ciliary dyskinesia (PCD) is a rare lung disease that is characterized by respiratory disorders, reduced fertility, and situs abnormalities. This study identified a patient with an unusually mild clinical phenotype and identified a homozygous non-canonical splice mutation in the ODAD1 gene. The mutant protein retains partial function, which explains the atypically mild clinical phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Yuyang Liu, Ying Shi, Mengwan Wu, Jialin Liu, Hong Wu, Chuan Xu, Ling Chen
Summary: PGCCs promote malignancy and immune-suppressive microenvironment in GBM. PGCCs or their progeny cells may be a potential therapeutic target for GBM.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Immunology
Goutham Vansarla, Anders P. Hakansson, Caroline Bergenfelz
Summary: HAMLET is a protein-lipid complex with specific antibacterial and antitumor activity, lacking cytotoxicity against healthy cells, while stimulating immune cells in humans and mice, inducing a pro-inflammatory response and enhancing the clearance of bacteria by activated immune cells.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Pegah Mehrpouya-Bahrami, Alina K. Moriarty, Paulo De Melo, W. Coles Keeter, Nada S. Alakhras, Andrew S. Nelson, Madeline Hoover, Maria S. Barrios, Jerry L. Nadler, C. Henrique Serezani, Mark H. Kaplan, Elena Galkina
Summary: STAT4 is essential for immunity to intracellular pathogens and plays a key role in neutrophil functions, including ROS production, chemotaxis, and formation of neutrophil extracellular traps. Deletion of STAT4 results in enhanced susceptibility to MRSA, highlighting its crucial involvement in innate immune responses.
Article
Engineering, Mechanical
Jin-Hong Jiang, Xu Yin, Guang-Kui Xu, Zi-Yu Wang, Li-Yuan Zhang
Summary: This paper proposes a novel type of tensegrity that can be easily converted into different types of tensegrities, providing a unified approach for their form-finding. By establishing unified form-finding models, the self-equilibrium and super-stability conditions of various types of tensegrities can be directly determined.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xandy Melissa Rodriguez Mesa, Leonardo Andres Contreras Bolanos, Geison Modesti Costa, Antonio Luis Mejia, Sandra Paola Santander Gonzalez
Summary: Bidens pilosa L. is traditionally used for medicinal purposes due to its anti-inflammatory, antinociceptive, and antioxidant properties. This study investigated the immunomodulatory effects of B. pilosa on antigen-presenting cells and found that the petroleum ether extract from the aerial part of the plant modulated the polarization and maturation state of macrophages and dendritic cells.
Article
Immunology
Yuyang Liu, Renqi Yao, Ying Shi, Yuxiao Liu, Hongyu Liu, Jialin Liu, Yunqian Guan, Yongming Yao, Ling Chen
Summary: This study comprehensively illustrated the potential function and predictive value of CD101 in patients with glioma. High levels of CD101 were associated with unfavorable clinical outcome, immune regulatory processes, and infiltration of immune cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Claudia C. S. Chini, Thais R. Peclat, Lilian S. Gomez, Julianna D. Zeidler, Gina M. Warner, Sonu Kashyap, Delaram Z. Z. Mazdeh, Faisal Hayat, Marie E. E. Migaud, Aneel Paulus, Asher A. A. Chanan-Khan, Eduardo N. N. Chini
Summary: Nicotinamide adenine dinucleotide (NAD) metabolism plays a crucial role in immune function regulation, but the complete understanding of how NAD and its metabolites, precursors, and enzymes work together in immune function and inflammatory diseases is still lacking. This study found that supplementation of NAD precursor NRH significantly increased NAD(+) levels in macrophages and activated a pro-inflammatory phenotype, inducing the expression of multiple cytokines, chemokines, and enzymes. Furthermore, NRH enhanced the effect of lipopolysaccharide on macrophage activation and cytokine gene expression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Clovis Boibessot, Oscar Molina, Gabriel Lachance, Christophe Tav, Audrey Champagne, Bertrand Neveu, Jean-Francois Pelletier, Frederic Pouliot, Vincent Fradet, Steve Bilodeau, Yves Fradet, Alain Bergeron, Paul Toren
Summary: Tumor-associated macrophages (TAMs) play a role in tumor progression within the tumor microenvironment. In prostate cancer patients, TAMs expressing the immunosuppressive marker CD163 independently predict metastases or prostate cancer death. The presence of prostate cancer cells and the cytokine milieu alter the phenotype of TAMs, which may promote tumor growth.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Polymer Science
Anabella P. Rosso, Marisa Martinelli
Summary: Dendritic thermo-responsive polymer-based nanogels were prepared using a precipitation methodology, incorporating dendritic building blocks and different percentages of crosslinker agents. Through detailed analysis of the property-structure relationship, nanogels of nanometric size with a potential application in the biomedical field were successfully prepared.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Cell Biology
Yasmin Luz, Amanda Reboucas, Carla Polyana O. S. Bernardes, Erik A. Rossi, Taise S. Machado, Bruno S. F. Souza, Claudia Ida Brodskyn, Patricia S. T. Veras, Washington L. C. dos Santos, Juliana P. B. de Menezes
Summary: This study aimed to investigate the effects of Leishmania infection on the migration of macrophages and dendritic cells in a 3D environment and shed light on the underlying mechanisms. The results showed that Leishmania infection inhibited 3D migration of macrophages, while enhancing 3D migration of dendritic cells, and these effects were associated with changes in tumor necrosis factor expression and cell adhesion.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Bowen Ni, Guanglong Huang, Runwei Yang, Ziyu Wang, Haimin Song, Kaishu Li, Yunxiao Zhang, Kezhi Wu, Guangwei Shi, Xiran Wang, Jie Shen, Yawei Liu
Summary: This study identified a novel membrane protein isoform, MS4A7-s, generated by alternative splicing in the glioblastoma (GBM) tumor microenvironment (TME). MS4A7-s is a specific M2 plasma membrane protein that plays a pro-oncogenic role in GBM TME. Higher expression of MS4A7-s is associated with poor prognosis in GBM patients. Furthermore, MS4A7-s promotes activation of the PI3K/AKT/GSK3 beta pathway in glioma-associated macrophages (GAMs), leading to M2 polarization and malignant progression of GBM.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Benedetta Mattorre, Silvana Caristi, Simona Donato, Emilia Volpe, Marika Faiella, Alessandro Paiardini, Rosa Sorrentino, Fabiana Paladini
Summary: The common expression of ERAP1 and IRAP in humans, as well as the evolution of ERAP2 under balancing selection leading to the generation of a short form, suggest a significant yet debated role of these metalloproteases in antigen presentation and other cellular processes, as evidenced by their complex interactions in macrophages and some cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Natallia Salei, Xingqi Ji, Dalia Pakalniskyte, Vanessa Kuentzel, Stephan Rambichler, Na Li, Markus Moser, Katja Steiger, Thorsten Buch, Hans-Joachim Anders, Barbara U. Schraml
Summary: A mouse model allowing for selective depletion of a specific subset of renal mononuclear phagocytes (MPs) was established, revealing the crucial role of CD64(+) MPs in cisplatin-induced kidney injury, while cDC1 and cDC2 were dispensable.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Kaveh Rahimi, Kambiz Hassanzadeh, Hashem Khanbabaei, Saeed Mohammadian Haftcheshmeh, Abbas Ahmadi, Esmael Izadpanah, Asadollah Mohammadi, Amirhossein Sahebkar
Summary: Dendritic cells (DCs) are crucial antigen-presenting cells in immune responses, and dysregulation of DCs can lead to inflammation or autoimmune diseases. Curcumin can modulate the function of DCs, inducing anti-inflammatory and immunomodulatory effects.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Tomoyoshi Sanada, Afsana Islam, Teppei Kaminota, Yui Kirino, Reina Tanimoto, Hana Yoshimitsu, Hajime Yano, Yosuke Mizuno, Masahiro Okada, Souhei Mitani, Tohru Ugumori, Junya Tanaka, Naohito Hato
Article
Biochemistry & Molecular Biology
Kensuke Umakoshi, Mohammed E. Choudhury, Ryutaro Nishioka, Hironori Matsumoto, Naoki Abe, Yuki Nishikawa, Satoshi Kikuchi, Jun Takeba, Hajime Yano, Toshihiro Yorozuya, Norio Sato, Mayuki Aibiki, Junya Tanaka
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Tasuku Nishihara, Junya Tanaka, Keisuke Sekiya, Yuki Nishikawa, Naoki Abe, Taisuke Hamada, Sakiko Kitamura, Keizo Ikemune, Shinichiro Ochi, Mohammed E. Choudhury, Hajime Yano, Toshihiro Yorozuya
NEUROCHEMISTRY INTERNATIONAL
(2020)
Review
Cell Biology
Naoki Abe, Tasuku Nishihara, Toshihiro Yorozuya, Junya Tanaka
Article
Biochemistry & Molecular Biology
Kazuya Miyanishi, Arisa Sato, Nanako Kihara, Ryo Utsunomiya, Junya Tanaka
Summary: Microglial cells in normal mature brains play a crucial role in phagocytosing synapses to maintain neural circuits and affect brain functions. Impaired synaptic elimination by microglia can disrupt the E/I balance, leading to various problems in memory, cognition, sleep, movement, social behaviors, and thinking. Additionally, disturbances in microglial phagocytosis functions are linked to neurological, mental, and developmental disorders like Parkinson's and Alzheimer's diseases, autism spectrum disorder, ADHD, and schizophrenia.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Cell Biology
Junya Tanaka, Hisaaki Takahashi, Hajime Yano, Hiroshi Nakanishi
Summary: This study demonstrates the presence of microglial progenitors expressing EGFR in the leptomeninges, indicating a population of microglia-like cells that grow independently of CSF1. The cells derived from leptomeninges resemble parenchymal microglia more closely than primary microglia.
Review
Biochemistry & Molecular Biology
Mohammed E. Choudhury, Yuka Kigami, Junya Tanaka
Summary: With the increasing age of the population, the incidence of Parkinson's disease has grown significantly. Microglia play important roles in both the degeneration of dopaminergic neurons and the compensatory mechanisms in different regions of the basal ganglia, making it challenging to target them for PD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Mohammed E. Choudhury, Kazuya Miyanishi, Haruna Takeda, Junya Tanaka
Summary: Aging leads to a reduction in brain microglial cells, disrupting the circadian rhythmicity of brain tissue, and microglial cells also play a role in sleep homeostasis and response to sleep loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Satoshi Tada, Mohammed E. Choudhury, Madoka Kubo, Rina Ando, Junya Tanaka, Masahiro Nagai
Summary: This study demonstrates the potential ameliorative effects of zonisamide on microglial mitochondrial dysfunction in Parkinson's disease, providing novel evidence for its clinical use as an antiparkinsonian drug.
Review
Oncology
Saya Ozaki, Kanta Mikami, Takeharu Kunieda, Junya Tanaka
Summary: CLICs are a type of ion channel proteins with potential as prognostic markers in cancer. This review focuses on CLIC2 and discusses its role in the metastasis and invasion of malignant tumor cells. CLIC2 may prevent malignant cell invasion and metastasis by inhibiting the activity of matrix metalloproteinase 14.
Article
Cell Biology
Ryo Utsunomiya, Kanta Mikami, Tomomi Doi, Mohammed E. Choudhury, Toshihiro Jogamoto, Naohito Tokunaga, Eiichi Ishii, Mariko Eguchi, Hajime Yano, Junya Tanaka
Summary: In addition to genetic factors, environmental factors also play a significant role in the development of attention deficit/hyperactivity disorder (ADHD). This study used Lister hooded rats as ADHD model animals and found that environmental conditions had a notable impact on the behavior and neural activity of the rats. Specifically, rats raised in an enriched environment showed improved ADHD-like behaviors, which were associated with reduced neuronal activity in the medial prefrontal cortex.
Article
Neurosciences
Mohammed E. Choudhury, Saya Ozaki, Noriyuki Miyaue, Taisei Matsuura, Kanta Mikami, Afsana Islam, Madoka Kubo, Rina Ando, Hajime Yano, Takeharu Kunieda, Masahiro Nagai, Junya Tanaka
Summary: Activated microglia potentially cause neurodegeneration in Parkinson's disease (PD). CLIC2 increases MMP-9 activity in microglia, which is involved in the pathogenesis of PD.
Article
Rehabilitation
Satoru Taguchi, Mohammed E. Choudhury, Kanta Mikami, Ryo Utsunomiya, Hajime Yano, Junya Tanaka
Summary: This study suggests that long-term exercise represses early response genes, increases resistance to stress, diminishes anxiety-related behavior, and improves social behavior.
ANNALS OF REHABILITATION MEDICINE-ARM
(2022)
Review
Oncology
Akihiro Inoue, Takanori Ohnishi, Masahiro Nishikawa, Yoshihiro Ohtsuka, Kosuke Kusakabe, Hajime Yano, Junya Tanaka, Takeharu Kunieda
Summary: Recurrence in glioblastoma may be caused by surviving glioma stem-like cells expressing high levels of CD44, which promote invasion and proliferation of tumor cells via various signaling pathways. Severe hypoxia activates genes related to cell invasion, whereas moderate hypoxia activates genes related to cell proliferation.
Article
Biochemistry & Molecular Biology
Akihiro Inoue, Takanori Ohnishi, Masahiro Nishikawa, Hideaki Watanabe, Kosuke Kusakabe, Mashio Taniwaki, Hajime Yano, Yoshihiro Ohtsuka, Shirabe Matsumoto, Satoshi Suehiro, Daisuke Yamashita, Seiji Shigekawa, Hisaaki Takahashi, Riko Kitazawa, Junya Tanaka, Takeharu Kunieda
Summary: This study analyzed the relationship between CD44 expression and magnetic resonance imaging (MRI)-based invasiveness of recurrent glioblastoma multiforme (GBM). High-invasive GBM showed significantly higher CD44 expression and was associated with worse survival. In addition, the study investigated the relationship between 5-aminolevulinic acid (5-ALA) spectroscopy-based tumor invasiveness and CD44 expression.