Journal
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
Volume 1800, Issue 8, Pages 760-769Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagen.2010.03.011
Keywords
Ferritin; Iron; Iron store; Ferritin receptor; Inflammation; Cancer
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Funding
- National Institutes of Health [R37 DK42421, R01DK71892]
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Background: Serum ferritin was discovered in the 1930s, and was developed as a clinical test in the 1970s. Many diseases are associated with iron overload or iron deficiency. Serum ferritin is widely used in diagnosing and monitoring these diseases. Scope of review: In this chapter, we discuss the role of serum ferritin in physiological and pathological processes and its use as a clinical tool. Major conclusions: Although many aspects of the fundamental biology of serum ferritin remain surprisingly unclear, a growing number of roles have been attributed to extracellular ferritin, including newly described roles in iron delivery, angiogenesis, inflammation, immunity, signaling and cancer. General significance: Serum ferritin remains a clinically useful tool. Further studies on the biology of this protein may provide new biological insights. (C) 2010 Elsevier B.V. All rights reserved.
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