The Role of CD4 T Cell Memory in Generating Protective Immunity to Novel and Potentially Pandemic Strains of Influenza

Somatic mutations and affinity maturation are impaired by excessive numbers of T follicular helper cells and restored by Treg cells or memory T cells

(2015) Silvia Preite et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Abundance and specificity of influenza reactive circulating memory follicular helper and non-follicular helper CD4 T cells in healthy adults

(2015) Scott A. Leddon et al.   IMMUNOLOGY

T follicular regulatory cells in the regulation of B cell responses

(2015) Peter T. Sage et al.   TRENDS IN IMMUNOLOGY

The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa

(2015) Heather D Marshall et al.   eLife

Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors

(2015) Michael Platten et al.   Frontiers in Immunology

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

Serological Responses to an Avian Influenza A/H7N9 Vaccine Mixed at the Point-of-Use With MF59 Adjuvant

(2014) Mark J. Mulligan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Healthy Human Subjects Have CD4+ T Cells Directed against H5N1 Influenza Virus

(2014) M. Roti et al.   JOURNAL OF IMMUNOLOGY

Circulating CXCR5+PD-1+Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults

(2014) Ramin Sedaghat Herati et al.   JOURNAL OF IMMUNOLOGY

Effect of Influenza A(H5N1) Vaccine Prepandemic Priming on CD4+ T-Cell Responses

(2014) Jennifer L. Nayak et al.   JOURNAL OF INFECTIOUS DISEASES

Seasonal Influenza Can Poise Hosts for CD4 T-Cell Immunity to H7N9 Avian Influenza

(2014) Katherine A. Richards et al.   JOURNAL OF INFECTIOUS DISEASES

Life of T Follicular Helper Cells

(2014) Woong-Kyung Suh   MOLECULES AND CELLS

Seeking Help: B Cells Adapting to Flu Variability

(2014) R. G. van der Most et al.   Science Translational Medicine

In the Shadow of Hemagglutinin: A Growing Interest in Influenza Viral Neuraminidase and Its Role as a Vaccine Antigen

(2014) Teddy Wohlbold et al.   Viruses-Basel

Plasticity of Human CD4 T Cell Subsets

(2014) Jens Geginat et al.   Frontiers in Immunology

The emergence of H7N9 viruses: a chance to redefine correlates of protection for influenza virus vaccines

(2013) Florian Krammer et al.   Expert Review of Vaccines

Circulating Precursor CCR7loPD-1hi CXCR5+ CD4+ T Cells Indicate Tfh Cell Activity and Promote Antibody Responses upon Antigen Reexposure

(2013) Jing He et al.   IMMUNITY

Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

(2013) Michela Locci et al.   IMMUNITY

Control of TFH cell numbers: why and how?

(2013) Alvin Pratama et al.   IMMUNOLOGY AND CELL BIOLOGY

Cutting Edge: Heterosubtypic Influenza Infection Antagonizes Elicitation of Immunological Reactivity to Hemagglutinin

(2013) J. L. Nayak et al.   JOURNAL OF IMMUNOLOGY

Human Cytotoxic T Lymphocytes Directed to Seasonal Influenza A Viruses Cross-React with the Newly Emerging H7N9 Virus

(2013) C. E. van de Sandt et al.   JOURNAL OF VIROLOGY

CD4 T Cell Help Is Limiting and Selective during the Primary B Cell Response to Influenza Virus Infection

(2013) S. Alam et al.   JOURNAL OF VIROLOGY

Increase in IFNγ−IL-2+ Cells in Recent Human CD4 T Cell Responses to 2009 Pandemic H1N1 Influenza

(2013) Jason M. Weaver et al.   PLoS One

Induction and Role of Indoleamine 2,3 Dioxygenase in Mouse Models of Influenza A Virus Infection

(2013) Lei Huang et al.   PLoS One

Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination

(2013) S.-E. Bentebibel et al.   Science Translational Medicine

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

Memory CD4+ T cells protect against influenza through multiple synergizing mechanisms

(2012) K. Kai McKinstry et al.   JOURNAL OF CLINICAL INVESTIGATION

Revealing the role of CD4+T cells in viral immunity: Figure 1.

(2012) Andrea J. Sant et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD4+ T-Cell Expansion Predicts Neutralizing Antibody Responses to Monovalent, Inactivated 2009 Pandemic Influenza A(H1N1) Virus Subtype H1N1 Vaccine

(2012) Jennifer L. Nayak et al.   JOURNAL OF INFECTIOUS DISEASES

Multifunctional CD4 Cells Expressing Gamma Interferon and Perforin Mediate Protection against Lethal Influenza Virus Infection

(2012) D. M. Brown et al.   JOURNAL OF VIROLOGY

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

(2012) Tom M Wilkinson et al.   NATURE MEDICINE

Evaluations for In Vitro Correlates of Immunogenicity of Inactivated Influenza A H5, H7 and H9 Vaccines in Humans

(2012) Robert B. Couch et al.   PLoS One

Indoleamine 2,3 dioxygenase and metabolic control of immune responses

(2012) David H. Munn et al.   TRENDS IN IMMUNOLOGY

Trivalent inactivated influenza vaccines induce broad immunological reactivity to both internal virion components and influenza surface proteins

(2012) Katherine A. Richards et al.   VACCINE

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion

(2011) Rimpei Morita et al.   IMMUNITY

The memory phase of the CD4 T-cell response to influenza virus infection maintains its diverse antigen specificity

(2011) Katherine A. Richards et al.   IMMUNOLOGY

Cross-protective immunity against influenza pH1N1 2009 viruses induced by seasonal influenza A (H3N2) virus is mediated by virus-specific T-cells

(2011) M. L. B. Hillaire et al.   JOURNAL OF GENERAL VIROLOGY

Infection with Seasonal Influenza Virus Elicits CD4 T Cells Specific for Genetically Conserved Epitopes That Can Be Rapidly Mobilized for Protective Immunity to Pandemic H1N1 Influenza Virus

(2011) S. Alam et al.   JOURNAL OF VIROLOGY

Repetitive Antigen Stimulation Induces Stepwise Transcriptome Diversification but Preserves a Core Signature of Memory CD8+ T Cell Differentiation

(2010) Thomas C. Wirth et al.   IMMUNITY

The potential of CD4 T-cell memory

(2010) K. Kai McKinstry et al.   IMMUNOLOGY

Memory CD4 T cells: generation, reactivation and re-assignment

(2010) Megan K.L. MacLeod et al.   IMMUNOLOGY

Cutting Edge: CD4 T Cells Generated from Encounter with Seasonal Influenza Viruses and Vaccines Have Broad Protein Specificity and Can Directly Recognize Naturally Generated Epitopes Derived from the Live Pandemic H1N1 Virus

(2010) K. A. Richards et al.   JOURNAL OF IMMUNOLOGY

Memory CD4 T Cells Direct Protective Responses to Influenza Virus in the Lungs through Helper-Independent Mechanisms

(2010) J. R. Teijaro et al.   JOURNAL OF VIROLOGY

Memory CD4+ T cells induce innate responses independently of pathogen

(2010) Tara M Strutt et al.   NATURE MEDICINE

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

(2010) J. J. O'Shea et al.   SCIENCE

Genome-wide screening of human T-cell epitopes in influenza A virus reveals a broad spectrum of CD4+ T-cell responses to internal proteins, hemagglutinins, and neuraminidases

(2009) Jenny Aurielle B. Babon et al.   HUMAN IMMUNOLOGY

Infection of HLA-DR1 Transgenic Mice with a Human Isolate of Influenza A Virus (H1N1) Primes a Diverse CD4 T-Cell Repertoire That Includes CD4 T Cells with Heterosubtypic Cross-Reactivity to Avian (H5N1) Influenza Virus

(2009) K. A. Richards et al.   JOURNAL OF VIROLOGY

Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic

(2009) Gavin J. D. Smith et al.   NATURE

Emergence and pandemic potential of swine-origin H1N1 influenza virus

(2009) Gabriele Neumann et al.   NATURE

CD8+ T lymphocyte mobilization to virus-infected tissue requires CD4+ T-cell help

(2009) Yusuke Nakanishi et al.   NATURE

In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses

(2009) Yasushi Itoh et al.   NATURE

Response to a Monovalent 2009 Influenza A (H1N1) Vaccine

(2009) Michael E. Greenberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Trial of 2009 Influenza A (H1N1) Monovalent MF59-Adjuvanted Vaccine

(2009) Tristan W. Clark et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pre-existing immunity against swine-origin H1N1 influenza viruses in the general human population

(2009) J. A. Greenbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

(2009) R. J. Garten et al.   SCIENCE

Selective CD4+ T Cell Help for Antibody Responses to a Large Viral Pathogen: Deterministic Linkage of Specificities

(2008) Alessandro Sette et al.   IMMUNITY

Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals

(2008) Laurel Yong-Hwa Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunomic Analysis of the Repertoire of T-Cell Specificities for Influenza A Virus in Humans

(2008) E. Assarsson et al.   JOURNAL OF VIROLOGY

In vitro evidence that commercial influenza vaccines are not similar in their ability to activate human T cell responses

(2008) Mary Dawn T. Co et al.   VACCINE