High molecular weight stress proteins: Identification, cloning and utilisation in cancer immunotherapy

Heat Shock Protein 70, Released from Heat-Stressed Tumor Cells, Initiates Antitumor Immunity by Inducing Tumor Cell Chemokine Production and Activating Dendritic Cells via TLR4 Pathway

(2014) T. Chen et al.   JOURNAL OF IMMUNOLOGY

A Multifunctional Chimeric Chaperone Serves as a Novel Immune Modulator Inducing Therapeutic Antitumor Immunity

(2013) X. Yu et al.   CANCER RESEARCH

Parecoxib Suppresses CHOP and Foxo1 Nuclear Translocation, but Increases GRP78 Levels in a Rat Model of Focal Ischemia

(2013) Zhi Ye et al.   NEUROCHEMICAL RESEARCH

Hypothermia Protects the Brain from Transient Global Ischemia/Reperfusion by Attenuating Endoplasmic Reticulum Response-Induced Apoptosis through CHOP

(2013) Xiaojie Liu et al.   PLoS One

Metazoan Hsp70 machines use Hsp110 to power protein disaggregation

(2012) Heike Rampelt et al.   EMBO JOURNAL

Heat shock proteins are therapeutic targets in autoimmune diseases and other chronic inflammatory conditions

(2012) Chantal Keijzer et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Scavenger receptor a restrains T-cell activation and protects against concanavalin A-induced hepatic injury

(2012) Daming Zuo et al.   HEPATOLOGY

Endoplasmic reticulum chaperone glucose regulated protein 170–Pokemon complexes elicit a robust antitumor immune response in vivo

(2012) Bangqing Yuan et al.   IMMUNOBIOLOGY

Human Heat Shock Protein 105/110 kDa (Hsp105/110) Regulates Biogenesis and Quality Control of Misfolded Cystic Fibrosis Transmembrane Conductance Regulator at Multiple Levels

(2012) Anita Saxena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Situ Vaccination with CD204 Gene-Silenced Dendritic Cell, not Unmodified Dendritic Cell, Enhances Radiation Therapy of Prostate Cancer

(2012) C. Guo et al.   MOLECULAR CANCER THERAPEUTICS

The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies

(2012) B Luo et al.   ONCOGENE

UPR-Induced Resistance to Etoposide Is Downstream of PERK and Independent of Changes in Topoisomerase IIα Levels

(2012) Melissa J. Mann et al.   PLoS One

Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis

(2012) M. J. C. van Herwijnen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Heat Shock Proteins in Antigen Cross Presentation

(2012) Ayesha Murshid et al.   Frontiers in Immunology

Characterization of stress sensitivity and chaperone activity of Hsp105 in mammalian cells

(2011) Nobuyuki Yamagishi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Serological identification of HSP105 as a novel non-Hodgkin lymphoma therapeutic target

(2011) R. Zappasodi et al.   BLOOD

Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines

(2011) Y Wang et al.   BRITISH JOURNAL OF CANCER

Targeting the Immunoregulator SRA/CD204 Potentiates Specific Dendritic Cell Vaccine-Induced T-cell Response and Antitumor Immunity

(2011) H. Yi et al.   CANCER RESEARCH

Molecular chaperoning by glucose-regulated protein 170 in the extracellular milieu promotes macrophage-mediated pathogen sensing and innate immunity

(2011) Daming Zuo et al.   FASEB JOURNAL

Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication

(2011) Sergio A. Quezada et al.   IMMUNOLOGICAL REVIEWS

Absence of scavenger receptor A promotes dendritic cell-mediated cross-presentation of cell-associated antigen and antitumor immune response

(2011) Chunqing Guo et al.   IMMUNOLOGY AND CELL BIOLOGY

Pattern Recognition Scavenger Receptor CD204 Attenuates Toll-like Receptor 4-induced NF-κB Activation by Directly Inhibiting Ubiquitination of Tumor Necrosis Factor (TNF) Receptor-associated Factor 6

(2011) Xiaofei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of Oxygen-regulated Protein 150 in AMP-activated Protein Kinase-mediated Alleviation of Lipid-induced Endoplasmic Reticulum Stress

(2011) Yun Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique Peptide Substrate Binding Properties of 110-kDa Heat-shock Protein (Hsp110) Determine Its Distinct Chaperone Activity

(2011) Xinping Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD204 Suppresses Large Heat Shock Protein-Facilitated Priming of Tumor Antigen gp100-Specific T Cells and Chaperone Vaccine Activity against Mouse Melanoma

(2011) J. Qian et al.   JOURNAL OF IMMUNOLOGY

Suppression of antigen-specific CD4+ T cell activation by SRA/CD204 through reducing the immunostimulatory capability of antigen-presenting cell

(2011) Huanfa Yi et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System

(2011) James Shorter   PLoS One

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

mda-7/IL-24: A unique member of the IL-10 gene family promoting cancer-targeted toxicity

(2010) Rupesh Dash et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Hsp105 reduces the protein aggregation and cytotoxicity by expanded-polyglutamine proteins through the induction of Hsp70

(2010) Nobuyuki Yamagishi et al.   EXPERIMENTAL CELL RESEARCH

Tumour secreted grp170 chaperones full-length protein substrates and induces an adaptive anti-tumour immune response in vivo

(2010) Hilal Arnouk et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

The Endoplasmic Reticulum Grp170 Acts as a Nucleotide Exchange Factor of Hsp70 via a Mechanism Similar to That of the Cytosolic Hsp110

(2010) Claes Andréasson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD30 Discriminates Heat Shock Protein 60-Induced FOXP3+CD4+ T Cells with a Regulatory Phenotype

(2010) I. de Kleer et al.   JOURNAL OF IMMUNOLOGY

Heat Shock Protein 90 Mediates Efficient Antigen Cross Presentation through the Scavenger Receptor Expressed by Endothelial Cells-I

(2010) A. Murshid et al.   JOURNAL OF IMMUNOLOGY

Superior Antitumor Response Induced by Large Stress Protein Chaperoned Protein Antigen Compared with Peptide Antigen

(2010) X. Y. Wang et al.   JOURNAL OF IMMUNOLOGY

Hsp110 Chaperones Control Client Fate Determination in the Hsp70–Hsp90 Chaperone System

(2010) Atin K. Mandal et al.   MOLECULAR BIOLOGY OF THE CELL

Vaccination with a chaperone complex based on PSCA and GRP170 adjuvant enhances the CTL response and inhibits the tumor growth in mice

(2010) Wenqian Huo et al.   VACCINE

Pattern recognition scavenger receptor SRA/CD204 down-regulates Toll-like receptor 4 signaling-dependent CD8 T-cell activation

(2009) H. Yi et al.   BLOOD

Secretion of stress protein grp170 promotes immune-mediated inhibition of murine prostate tumor

(2009) Ping Gao et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Caught with their PAMPs down? The extracellular signalling actions of molecular chaperones are not due to microbial contaminants

(2009) Brian Henderson et al.   CELL STRESS & CHAPERONES

Nucleotide Binding by Lhs1p Is Essential for Its Nucleotide Exchange Activity and for Functionin Vivo

(2009) Jeanine de Keyzer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T Cell Activation by Heat Shock Protein 70 Vaccine Requires TLR Signaling and Scavenger Receptor Expressed by Endothelial Cells-1

(2009) J. Gong et al.   JOURNAL OF IMMUNOLOGY

Heat shock proteins and immune system

(2009) Min-Fu Tsan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Vaccination of metastatic renal cell carcinoma patients with autologous tumour-derived vitespen vaccine: clinical findings

(2008) E Jonasch et al.   BRITISH JOURNAL OF CANCER

Secretable Chaperone Grp170 Enhances Therapeutic Activity of a Novel Tumor Suppressor, mda-7/IL-24

(2008) P. Gao et al.   CANCER RESEARCH

Structural Basis for the Cooperation of Hsp70 and Hsp110 Chaperones in Protein Folding

(2008) Sigrun Polier et al.   CELL

Heat-shock proteins in cancer vaccines: agents of antigen cross-presentation

(2008) Ayesha Murshid et al.   Expert Review of Vaccines

Phase III Comparison of Vitespen, an Autologous Tumor-Derived Heat Shock Protein gp96 Peptide Complex Vaccine, With Physician's Choice of Treatment for Stage IV Melanoma: The C-100-21 Study Group

(2008) Alessandro Testori et al.   JOURNAL OF CLINICAL ONCOLOGY

An adjuvant autologous therapeutic vaccine (HSPPC-96; vitespen) versus observation alone for patients at high risk of recurrence after nephrectomy for renal cell carcinoma: a multicentre, open-label, randomised phase III trial

(2008) Christopher Wood et al.   LANCET

Differential expression of heat shock protein 105 in melanoma and melanocytic naevi

(2008) Faith Chengetayi Muchemwa et al.   MELANOMA RESEARCH

Insights into the structural dynamics of the Hsp110-Hsp70 interaction reveal the mechanism for nucleotide exchange activity

(2008) C. Andreasson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA