Regulatory T-Cell-Mediated Suppression of Conventional T-Cells and Dendritic Cells by Different cAMP Intracellular Pathways

Exchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppression

(2015) Muayad Almahariq et al.   BIOCHEMICAL JOURNAL

Neonatal regulatory T cells have reduced capacity to suppress dendritic cell function

(2015) Cesar M. Rueda et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T Cell–Derived Adenosine Induces Dendritic Cell Migration through the Epac-Rap1 Pathway

(2015) Sabine Ring et al.   JOURNAL OF IMMUNOLOGY

Extracellular adenosine metabolism in immune cells in melanoma

(2014) Viktor Umansky et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Human CD4+CD39+regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+exosomes or CD73+cells

(2014) P. J. Schuler et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Surface expression of CD39 identifies an enriched Treg-cell subset in the rheumatic joint, which does not suppress IL-17A secretion

(2014) Jessica Herrath et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Bordetella Adenylate Cyclase Toxin Differentially Modulates Toll-Like Receptor-Stimulated Activation, Migration and T Cell Stimulatory Capacity of Dendritic Cells

(2014) Irena Adkins et al.   PLoS One

Extracellular ATP drives systemic inflammation, tissue damage and mortality

(2014) A Cauwels et al.   Cell Death & Disease

Regulatory T Cells Diminish HIV Infection in Dendritic Cells – Conventional CD4+ T Cell Clusters

(2014) Maria E. Moreno-Fernandez et al.   Frontiers in Immunology

Extracellular Adenosine-Mediated Modulation of Regulatory T Cells

(2014) Akio Ohta et al.   Frontiers in Immunology

Regulatory T-cells and cAMP suppress effector T-cells independently of PKA–CREM/ICER: a potential role for Epac

(2013) Amanda G. Vang et al.   BIOCHEMICAL JOURNAL

Interferon-  Suppresses cAMP to Disarm Human Regulatory T Cells

(2013) N. Bacher et al.   CANCER RESEARCH

CD73 expression on extracellular vesicles derived from CD4+CD25+Foxp3+T cells contributes to their regulatory function

(2013) Lesley Ann Smyth et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Beta2-adrenergic receptor signaling in CD4+Foxp3+regulatory T cells enhances their suppressive function in a PKA-dependent manner

(2013) Marcia G. Guereschi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Soluble Ecto-5′-nucleotidase (5′-NT), Alkaline Phosphatase, and Adenosine Deaminase (ADA1) Activities in Neonatal Blood Favor Elevated Extracellular Adenosine

(2013) Matthew Pettengill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Cyclic Nucleotide Phosphodiesterases in Modulating T Cell Responses in Murine Graft-versus-Host Disease

(2013) Michael Weber et al.   PLoS One

Regulatory T Cells Negatively Affect IL-2 Production of Effector T Cells through CD39/Adenosine Pathway in HIV Infection

(2013) Mohammad-Ali Jenabian et al.   PLoS Pathogens

Cyclic AMP underpins suppression by regulatory T cells

(2012) Josef Bodor et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Phenotypic and functional characteristics of CD4+CD39+ FOXP3+ and CD4+CD39+FOXP3neg T-cell subsets in cancer patients

(2012) Patrick J. Schuler et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The development and immunosuppressive functions of CD4+ CD25+ FoxP3+ regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway

(2012) Akio Ohta et al.   Frontiers in Immunology

Regulatory T cells control HIV replication in activated T cells through a cAMP-dependent mechanism

(2011) M. E. Moreno-Fernandez et al.   BLOOD

Cancer Exosomes Express CD39 and CD73, Which Suppress T Cells through Adenosine Production

(2011) A. Clayton et al.   JOURNAL OF IMMUNOLOGY

Repression of Cyclic Adenosine Monophosphate Upregulation Disarms and Expands Human Regulatory T Cells

(2011) M. Klein et al.   JOURNAL OF IMMUNOLOGY

Next-generation insights into regulatory T cells: expression profiling and FoxP3 occupancy in Human

(2011) Fabian Birzele et al.   NUCLEIC ACIDS RESEARCH

Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1)

(2011) M. Vaeth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Regulatory T Cells Produced by Inhibiting Cyclic Nucleotide Phosphodiesterase Type 3 Prevent Allograft Rejection

(2011) G. Feng et al.   Science Translational Medicine

Expression of CD39 by Human Peripheral Blood CD4+CD25+ T Cells Denotes a Regulatory Memory Phenotype

(2010) K. M. Dwyer et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Cyclic adenosine monophosphate and IL-10 coordinately contribute to nTreg cell-mediated suppression of dendritic cell activation

(2010) Melanie Fassbender et al.   CELLULAR IMMUNOLOGY

Rap1A regulates generation of T regulatory cells via LFA-1-dependent and LFA-1-independent mechanisms

(2010) Lequn Li et al.   CELLULAR IMMUNOLOGY

Gap junctions between regulatory T cells and dendritic cells prevent sensitization of CD8+ T cells

(2010) Sabine Ring et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Crosstalk Between PKA and Epac Regulates the Phenotypic Maturation and Function of Human Dendritic Cells

(2010) J. Garay et al.   JOURNAL OF IMMUNOLOGY

Distinct Roles of Adenylyl Cyclase VII in Regulating the Immune Responses in Mice

(2010) B. Duan et al.   JOURNAL OF IMMUNOLOGY

Much Ado about Adenosine: Adenosine Synthesis and Function in Regulatory T Cell Biology

(2010) P. B. Ernst et al.   JOURNAL OF IMMUNOLOGY

Generation and Accumulation of Immunosuppressive Adenosine by Human CD4+CD25highFOXP3+Regulatory T Cells

(2009) Magis Mandapathil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sumoylation of the Transcription Factor NFATc1 Leads to Its Subnuclear Relocalization and Interleukin-2 Repression by Histone Deacetylase

(2009) Arnab Nayak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of cAMP Degradation Improves Regulatory T Cell-Mediated Suppression

(2009) T. Bopp et al.   JOURNAL OF IMMUNOLOGY

CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis

(2009) J. M. Fletcher et al.   JOURNAL OF IMMUNOLOGY

Nonfunctional Regulatory T Cells and Defective Control of Th2 Cytokine Production in Natural Scurfy Mutant Mice

(2009) K. Lahl et al.   JOURNAL OF IMMUNOLOGY

CD73 Is Expressed by Human Regulatory T Helper Cells and Suppresses Proinflammatory Cytokine Production andHelicobacter felis–Induced Gastritis in Mice

(2009) Mohammad S. Alam et al.   JOURNAL OF INFECTIOUS DISEASES

Distinct metabolism of cyclic adenosine monophosphate in regulatory and helper CD4+ T cells

(2009) Alexandr V. Bazhin et al.   MOLECULAR IMMUNOLOGY

Epac and PKA: a tale of two intracellular cAMP receptors

(2008) Xiaodong Cheng et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

miR-142-3p restricts cAMP production in CD4+CD25− T cells and CD4+CD25+ TREG cells by targeting AC9 mRNA

(2008) Bo Huang et al.   EMBO REPORTS

Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation

(2008) Y. Onishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA