Advancing our understanding of infant bronchiolitis through phenotyping and endotyping: clinical and molecular approaches

Treatable traits: toward precision medicine of chronic airway diseases

(2016) Alvar Agusti et al.   EUROPEAN RESPIRATORY JOURNAL

β2-Adrenergic receptor promoter haplotype influences the severity of acute viral respiratory tract infection during infancy: a prospective cohort study

(2015) Pingsheng Wu et al.   BMC Medical Genetics

The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma Development

(2015) Shu Mei Teo et al.   Cell Host & Microbe

Interleukin-15 is associated with disease severity in viral bronchiolitis

(2015) T. Ronan Leahy et al.   EUROPEAN RESPIRATORY JOURNAL

Change in the manifestations of asthma and asthma-related traits in childhood: a latent transition analysis

(2015) Frances L. Garden et al.   EUROPEAN RESPIRATORY JOURNAL

Genes associated with RSV lower respiratory tract infection and asthma: the application of genetic epidemiological methods to understand causality

(2015) Emma K Larkin et al.   Future Virology

Duration of wheezy episodes in early childhood is independent of the microbial trigger

(2015) Christian J. Carlsson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Endogenous metabolites and inflammasome activity in early childhood and links to respiratory diseases

(2015) Gunda Herberth et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The airway microbiome in patients with severe asthma: Associations with disease features and severity

(2015) Yvonne J. Huang et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Systems biology of asthma and allergic diseases: A multiscale approach

(2015) Supinda Bunyavanich et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Hospital course and discharge criteria for children hospitalized with bronchiolitis

(2015) Jonathan M. Mansbach et al.   Journal of Hospital Medicine

Metabolomic Endotype of Asthma

(2015) Suzy A. A. Comhair et al.   JOURNAL OF IMMUNOLOGY

Infectious Disease-related Emergency Department Visits Among Children in the US

(2015) Kohei Hasegawa et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Data-Driven Asthma Endotypes Defined from Blood Biomarker and Gene Expression Data

(2015) Barbara Jane George et al.   PLoS One

Objectives, design and enrollment results from the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure Study (INSPIRE)

(2015) Emma K Larkin et al.   BMC Pulmonary Medicine

Bronchiolitis in children: summary of NICE guidance

(2015) V. Ricci et al.   BMJ-British Medical Journal

Bronchiolitis in children: summary of NICE guidance

(2015) V. Ricci et al.   BMJ-British Medical Journal

Early Respiratory Microbiota Composition Determines Bacterial Succession Patterns and Respiratory Health in Children

(2014) Giske Biesbroek et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Gene Expression in Relation to Exhaled Nitric Oxide Identifies Novel Asthma Phenotypes with Unique Biomolecular Pathways

(2014) Brian D. Modena et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Nasopharyngeal gene expression, a novel approach to study the course of respiratory syncytial virus infection

(2014) Corné H. van den Kieboom et al.   EUROPEAN RESPIRATORY JOURNAL

Infectious pathogens and bronchiolitis outcomes

(2014) Kohei Hasegawa et al.   Expert Review of Anti-Infective Therapy

MicroRNAs and the immune response to respiratory virus infections

(2014) Anna Głobińska et al.   Expert Review of Clinical Immunology

MicroRNAs in the interaction between host and bacterial pathogens

(2014) Claire Maudet et al.   FEBS LETTERS

Detection of pathogenic bacteria during rhinovirus infection is associated with increased respiratory symptoms and asthma exacerbations

(2014) Kirsten M. Kloepfer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Respiratory Syncytial Virus Genomic Load and Disease Severity Among Children Hospitalized With Bronchiolitis: Multicenter Cohort Studies in the United States and Finland

(2014) K. Hasegawa et al.   JOURNAL OF INFECTIOUS DISEASES

Association Between Breast-Feeding and Severity of Acute Viral Respiratory Tract Infection

(2014) Shanda Vereen et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Hospital Length-of-stay Is Associated With Rhinovirus Etiology of Bronchiolitis

(2014) Tuomas Jartti et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Multicenter Study of Viral Etiology and Relapse in Hospitalized Children With Bronchiolitis

(2014) Kohei Hasegawa et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Clinical Practice Guideline: The Diagnosis, Management, and Prevention of Bronchiolitis

(2014) S. L. Ralston et al.   PEDIATRICS

Neonatal Airway Colonization Is Associated with Troublesome Lung Symptoms in Infants

(2013) Marie-Louise von Linstow et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Increased Risk of Pneumonia and Bronchiolitis after Bacterial Colonization of the Airways as Neonates

(2013) Nadja H. Vissing et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pathogenic Bacteria Colonizing the Airways in Asymptomatic Neonates Stimulates Topical Inflammatory Mediator Release

(2013) Nilofar V. Følsgaard et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Decision tree-based method for integrating gene expression, demographic, and clinical data to determine disease endotypes

(2013) ClarLynda R Williams-DeVane et al.   BMC Systems Biology

The impact of viral genotype on pathogenesis and disease severity: respiratory syncytial virus and human rhinoviruses

(2013) Martin L Moore et al.   CURRENT OPINION IN IMMUNOLOGY

Epigenetic changes associated with disease progression in a mouse model of childhood allergic asthma

(2013) A. Collison et al.   Disease Models & Mechanisms

Epidemiological and genetic characteristics associated with the severity of acute viral bronchiolitis by respiratory syncytial virus

(2013) Alfonso Eduardo Alvarez et al.   Jornal de Pediatria

Nasopharyngeal Proteobacteria are associated with viral etiology and acute wheezing in children with severe bronchiolitis

(2013) Embriette R. Hyde et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis

(2013) Harish Nair et al.   LANCET

Viral Etiologies of Infant Bronchiolitis, Croup and Upper Respiratory Illness During 4 Consecutive Years

(2013) E. Kathryn Miller et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Temporal Trends in Emergency Department Visits for Bronchiolitis in the United States, 2006 to 2010

(2013) Kohei Hasegawa et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Oral Dexamethasone for Bronchiolitis: A Randomized Trial

(2013) K. Alansari et al.   PEDIATRICS

Trends in Bronchiolitis Hospitalizations in the United States, 2000-2009

(2013) K. Hasegawa et al.   PEDIATRICS

Molecular Epidemiology and Disease Severity of Human Respiratory Syncytial Virus in Vietnam

(2013) Dinh Nguyen Tran et al.   PLoS One

Moving from the Oslerian paradigm to the post-genomic era: are asthma and COPD outdated terms?

(2013) Lowie E G W Vanfleteren et al.   THORAX

Whole Blood Gene Expression Profiles to Assess Pathogenesis and Disease Severity in Infants with Respiratory Syncytial Virus Infection

(2013) Asuncion Mejias et al.   PLOS MEDICINE

Human Rhinovirus Species and Season of Infection Determine Illness Severity

(2012) Wai-Ming Lee et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Prospective Multicenter Study of Viral Etiology and Hospital Length of Stay in Children With Severe Bronchiolitis

(2012) Pedro A. Piedra   ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE

Two novel, severe asthma phenotypes identified during childhood using a clustering approach

(2012) Jocelyne Just et al.   EUROPEAN RESPIRATORY JOURNAL

Influenza A Virus Infection of Human Respiratory Cells Induces Primary MicroRNA Expression

(2012) William A. Buggele et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Respiratory syncytial virus modifies microRNAs regulating host genes that affect virus replication

(2012) A. Bakre et al.   JOURNAL OF GENERAL VIROLOGY

Asthma phenotypes: the evolution from clinical to molecular approaches

(2012) Sally E Wenzel   NATURE MEDICINE

Global Gene Expression Profiling in Infants With Acute Respiratory Syncytial Virus Broncholitis Demonstrates Systemic Activation of Interferon Signaling Networks

(2012) Kristine L. Bucasas et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

In vitro modeling of respiratory syncytial virus infection of pediatric bronchial epithelium, the primary target of infection in vivo

(2012) R. Villenave et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

(2012) T. Olszak et al.   SCIENCE

NEW: Network-Enabled Wisdom in Biology, Medicine, and Health Care

(2012) E. E. Schadt et al.   Science Translational Medicine

Dysregulation of Allergic Airway Inflammation in the Absence of Microbial Colonization

(2011) Tina Herbst et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Host and viral factors associated with severity of human rhinovirus–associated infant respiratory tract illness

(2011) E. Kathryn Miller et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome

(2011) Jan Lötvall et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Microbiota Modulate Host Gene Expression via MicroRNAs

(2011) Guillaume Dalmasso et al.   PLoS One

Th2-associated immunity to bacteria in teenagers and susceptibility to asthma

(2010) E. M. Hollams et al.   EUROPEAN RESPIRATORY JOURNAL

Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis

(2010) Harish Nair et al.   LANCET

High prevalence of human rhinovirus C infection in Thai children with acute lower respiratory tract disease

(2009) Piyada Linsuwanon et al.   JOURNAL OF INFECTION

Clinical and Molecular Epidemiology of Human Rhinovirus C in Children and Adults in Hong Kong Reveals a Possible Distinct Human Rhinovirus C Subgroup

(2009) Susanna K. P. Lau et al.   JOURNAL OF INFECTIOUS DISEASES

In Very Young Infants Severity of Acute Bronchiolitis Depends On Carried Viruses

(2009) Christophe Marguet et al.   PLoS One

Evidence of Recombination and Genetic Diversity in Human Rhinoviruses in Children with Acute Respiratory Infection

(2009) Ting Huang et al.   PLoS One

Increased Concordance of Severe Respiratory Syncytial Virus Infection in Identical Twins

(2008) S. F. Thomsen et al.   PEDIATRICS