Article
Immunology
Pekka Hurme, Miisa Komulainen, Marleena Tulkki, Annamari Leino, Beate Ruckert, Riitta Turunen, Tytti Vuorinen, Mubeccel Akdis, Cezmi A. Akdis, Tuomas Jartti
Summary: The cytokine profiles of Rhinovirus (RV) and respiratory syncytial virus (RSV)-induced first wheezing episode differ, with higher cytokine expression and longer hospitalization time in the RSV group. In the RV group, increased expression of I-309 (CCL1) and TARC is associated with fewer relapses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Chun Yi Lee, Chia Hsin Sung, Meng Che Wu, Yu Chuan Chang, Jih Chin Chang, Yu Ping Fang, Nancy M. Wang, Teh Ying Chou, Yu Jiun Chan
Summary: This study investigated the clinical characteristics and cytokines/chemokines profiles among respiratory syncytial virus (RSV), rhinovirus (RV), and their dual infection in Taiwanese children with viral bronchiolitis. The findings revealed that RV bronchiolitis had comparable severity to RSV but was more common in older children with a history of recurrent wheezing and blood eosinophilia. Different viral infections elicited characteristic clinical presentations and immune profiles in bronchiolitis. The study also highlighted the role of the IL-33/IL-31 axis in the immunopathogenesis of bronchiolitis.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Review
Allergy
Heidi Makrinioti, Kohei Hasegawa, John Lakoumentas, Paraskevi Xepapadaki, Maria Tsolia, Jose A. Castro-Rodriguez, Wojciech Feleszko, Tuomas Jartti, Sebastian L. Johnston, Andrew Bush, Vasiliki Papaevangelou, Carlos A. Camargo, Nikolaos G. Papadopoulos
Summary: This study compares the associations of RSV-induced bronchiolitis and RV-induced bronchiolitis with the development of preschool wheeze and childhood asthma through a meta-analysis. The results show that the RV-bronchiolitis group is more likely to develop recurrent wheeze and asthma. This study is clinically significant for understanding the relationship between viruses and asthma.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Pediatrics
Julie Magnier, Valerie Julian, Aurelien Mulliez, Alexandra Usclade, Emmanuelle Rochette, Bertrand Evrard, Flore Amat, Carole Egron
Summary: The study revealed that male infants with a family history of allergies may be at higher risk for asthma at school age following their first episode of acute bronchiolitis. Additionally, rhinovirus infection and specific gene may have significant associations with asthma at age seven.
Article
Pediatrics
Juliana Cristina Santiago Bastos, Paulo Vitor Marques Simas, Leonardo Cardia Caserta, Alfonso Eduardo Alvarez Bragunde, Fernando Augusto de Lima Marson, Matheus Cavalheiro Martini, Marina Aiello Padilla, Jose Dirceu Ribeiro, Marcia Merces Aparecida Bianchi dos Santos, Clarice Weis Arns
Summary: RSV and rhinoviruses are the most commonly detected viruses in severe bronchiolitis cases in infants. However, a significant portion of cases do not show RSV presence, indicating the presence of other viral agents like rhinoviruses.
JORNAL DE PEDIATRIA
(2022)
Article
Immunology
Ryohei Shibata, Zhaozhong Zhu, Tadao Ooka, Robert J. Freishtat, Jonathan M. Mansbach, Marcos Perez-Losada, Ignacio Ramos-Tapia, Stephen Teach, Carlos A. Camargo, Kohei Hasegawa
Summary: Using tIgE and virus data, we identified phenotypes of infant bronchiolitis and studied their association with asthma development and biological characteristics. We found 4 phenotypes, and infants with the tIgE(high)virus(RSV-low/RV) phenotype had a significantly higher risk for developing asthma. These phenotypes also exhibited different biological characteristics, such as depleted type I interferon and enriched antigen presentation pathways.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Orianne Dumas, Riku Erkkola, Eija Bergroth, Kohei Hasegawa, Jonathan M. Mansbach, Pedro A. Piedra, Tuomas Jartti, Carlos A. Camargo
Summary: This study aimed to investigate the association between severe bronchiolitis profiles identified by clustering and childhood asthma. The results showed that children with a history of wheezing and/or eczema and rhinovirus infection had a higher risk of developing childhood asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Virology
Styliani Pappa, Katerina Haidopoulou, Charalampos Zarras, Eleni Theodorakou, Eleni Papadimitriou, Elias Iosifidis, Ioanna Gkeka, Konstantina Stoikou, Eleni Vagdatli, Lemonia Skoura, Anna Papa
Summary: An unexpected surge of RSV infections among children was observed in Greece, with RSV-A being the predominant subtype. This may be attributed to the lack of immunity among children and mothers due to the COVID-19 pandemic. Awareness and molecular epidemiology are crucial for diagnosing and monitoring RSV infections.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Medicine, General & Internal
Sergio de Jesus Romero-Tapia, Crystell Guadalupe Guzman Priego, Blanca E. Del-Rio-Navarro, Manuel Sanchez-Solis
Summary: This review summarizes the close association between viral infection and the onset, progression, and exacerbation of asthma, discussing related protective and risk factors, as well as treatment options. It also presents recent research on the innate immunological pathways and changes in the epithelial barrier. The review emphasizes the importance of genetics and epigenetics in asthma and virus susceptibility, and describes the involvement of viral etiology in bronchiolitis, childhood wheezing, and asthma. The most frequently related respiratory viruses and their mechanisms of action are mentioned.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Mina Suh, Naimisha Movva, Xiaohui Jiang, Lauren C. Bylsma, Heidi Reichert, Jon P. Fryzek, Christopher B. Nelson
Summary: This study demonstrates that acute bronchiolitis due to RSV is the leading cause of hospitalizations in US infants, especially during the winter months.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
E. Murillo-Zamora, O. Mendoza-Cano, M. Huerta, M. Rios-Silva, A. Lugo-Radillo, V. Benites-Godinez, J. A. Bricio-Barrios, E. F. Rios-Bracamontes, X. Trujillo
Summary: The objective of this study was to assess the survival experience of children hospitalized with laboratory-confirmed respiratory syncytial virus (RSV) infection due to bronchiolitis. A nationwide retrospective cohort study was conducted in Mexico, analyzing data from 436 children aged 5 years and younger. High survival rates were observed within the first three weeks of hospital admission, with a mortality rate of 2.1 per 1,000 person-days.
Review
Immunology
Heidi Makrinioti, Andrew Bush, James Gern, Sebastian Lennox Johnston, Nikolaos Papadopoulos, Wojciech Feleszko, Carlos A. Camargo, Kohei Hasegawa, Tuomas Jartti
Summary: Bronchiolitis is a common cause of hospitalization in infants and is associated with a higher risk of childhood asthma development. The mechanisms underlying asthma development following bronchiolitis hospitalization are complex and involve immune responses to respiratory viruses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Jennifer Simpson, Kirsten M. Spann, Simon Phipps
Summary: RSV infection of hAECs leads to early and late release of HMGB1. Early release is independent of cell death but can be attenuated by inhibiting MLKL. Early release promotes late release and cell death via activation of RAGE. Inhibition of MLKL or targeting the HMGB1/RAGE pathway can attenuate the release of pro-inflammatory HMGB1 and decrease viral load.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Jaime Fergie, Mina Suh, Xiaohui Jiang, Jon P. Fryzek, Tara Gonzales
Summary: This study found an increase in the burden and severity of respiratory syncytial virus (RSV) hospitalizations and all-cause bronchiolitis hospitalizations among otherwise healthy 29-34 weeks' gestational age infants aged <6 months after 2014. The American Academy of Pediatrics' recommendation change regarding palivizumab usage may have contributed to this increase.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Heidi Reichert, Mina Suh, Xiaohui Jiang, Naimisha Movva, Lauren C. Bylsma, Jon P. Fryzek, Christopher B. Nelson
Summary: This study describes the mortality rate of infants in the United States due to respiratory syncytial virus (RSV). The highest mortality rates were observed among infants with a gestational age of less than 29 weeks, American Indian/Alaskan Native infants, and Medicaid-insured infants. However, the burden of RSV mortality was greatest in full-term infants, white infants, and Medicaid-insured infants.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Pediatrics
Giulia M. Martone, Heather K. Lehman, Todd C. Rideout, Divya Choudhary, Claire E. Cameron, Emily Oken, Sheryl L. Rifas-Shiman, Carlos A. Camargo, Diane R. Gold, Xiaozhong Wen
Summary: The study found that children who had delayed introduction of eggs after 12 months had a significantly higher risk of egg allergy at 2 years and the risk persisted into early adolescence at 12 years. This suggests that introducing eggs before 12 months could help prevent egg allergy.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2023)
Article
Critical Care Medicine
Brandon-R. Bedell, Krislyn-M. Boggs, Janice-A. Espinola, Ashley-F. Sullivan, Kohei Hasegawa, Margaret Samuels-Kalow, Kori -S. Zachrison, Carlos-A. Camargo Jr
Summary: There are discrepancies between trauma center certifications in the U.S., with many states maintaining unique certification systems. This study investigates the similarity between the national trauma certification program established by the American College of Surgeons (ACS) and state certifications, and creates a unified national trauma center database.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Nutrition & Dietetics
Raphaelle Varraso, Orianne Dumas, Fred K. Tabung, Krislyn M. Boggs, Teresa T. Fung, Frank Hu, Edward Giovannucci, Frank E. Speizer, Walter C. Willett, Carlos A. Camargo
Summary: This study aimed to determine if adherence to a healthful plant-based diet is associated with a lower risk of COPD, while adherence to an unhealthful plant-based diet is associated with a higher risk of COPD. Findings showed that participants with the highest hPDI score had a 46% lower risk of COPD, while those with the highest uPDI score had a 39% higher risk of COPD.
Article
Allergy
Rachel L. Miller, Holly Schuh, Aruna Chandran, Izzuddin M. Aris, Casper Bendixsen, Jeffrey Blossom, Carrie Breton, Carlos A. Camargo Jr, Glorisa Canino, Kecia N. Carroll, Sarah Commodore, Jose F. Cordero, Dana M. Dabelea, Assiamira Ferrara, Rebecca C. Fry, Jody M. Ganiban, James E. Gern, Frank D. Gilliland, Diane R. Gold, Rima Habre, Marion E. Hare, Robyn N. Harte, Tina Hartert, Kohei Hasegawa, Gurjit K. Khurana Hershey, Daniel J. Jackson, Christine Joseph, Jean M. Kerver, Haejin Kim, Augusto A. Litonjua, Carmen J. Marsit, Cindy McEvoy, Eneida A. Mendonca, Paul E. Moore, Flory L. Nkoy, Thomas G. O'Connor, Emily Oken, Dennis Ownby, Matthew Perzanowski, Katherine Rivera-Spoljaric, Patrick H. Ryan, Anne Marie Singh, Joseph B. Stanford, Rosalind J. Wright, Robert O. Wright, Antonella Zanobetti, Edward Zoratti, Christine C. Johnson
Summary: This study found that the incidence rates of asthma with recurrent exacerbations (ARE) are influenced by time, geography, age, race and ethnicity, sex, and parental history. Children aged 2-4 years, Hispanic Black and non-Hispanic Black children, and those with a parental history of asthma had the highest rates of ARE.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Michihito Kyo, Zhaozhong Zhu, Ryohei Shibata, Michimasa Fujiogi, Jonathan M. Mansbach, Carlos A. Camargo, Kohei Hasegawa
Summary: This study identified specific nasopharyngeal lipids that can differentiate between respiratory syncytial virus (RSV) and rhinovirus (RV) bronchiolitis in infants. These lipids, including phosphatidylcholine (18:2/18:2), dihydroceramide (16:0), and eicosapentaenoic acid, are also associated with the severity of bronchiolitis.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Obstetrics & Gynecology
Steven J. Ondersma, Amii M. Kress, Annemarie Stroustrup, Robert D. Annett, Lyndsay A. Avalos, Maria Talavera-Barber, Patricia A. Brennan, Carlos A. Camargo, Elisabeth Conradt, Anne L. Dunlop, Amy J. Elliott, Monique M. Hedderson, Ximin Li, Monica McGrath, Ruby H. N. Nguyen, Grier P. Page, Sheela Sathyanarayana, Barry Lester
JOURNAL OF PERINATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Heidi Makrinioti, Zhaozhong Zhu, Carlos A. Camargo, Valentina Fainardi, Kohei Hasegawa, Andrew Bush, Sejal Saglani
Summary: Obesity-related asthma in childhood is a heterogeneous phenotype, with prevalence increasing. Observational studies have found that early-life obesity or weight gain are risk factors for childhood asthma development, and the reverse association is also described. Obese children with asthma have poorer symptom control and more asthma attacks compared to non-obese children with asthma. Clinical trials have found that some obese children with asthma do not respond well to usual treatment.
Letter
Medicine, General & Internal
Christopher L. Bennett, Krislyn M. Boggs, Cameron J. Gettel, Wendy W. Sun, Arjun K. Venkatesh, Carlos A. Camargo
Article
Emergency Medicine
Son H. McLaren, Ying Shelly Qi, Janice A. Espinola, Jonathan M. Mansbach, Peter S. Dayan, Carlos A. Camargo
Summary: This article aims to identify characteristics associated with mild bronchiolitis in infants <= 90 days old. The results show that older age (61-90 days), adequate oral intake, and oxygen saturation >= 94% are factors associated with mild bronchiolitis.
JOURNAL OF THE AMERICAN COLLEGE OF EMERGENCY PHYSICIANS OPEN
(2023)
Article
Emergency Medicine
Scott A. Goldberg, Emma Chadwick, Supriya Makam, Hridaya J. Shah, Michelle B. Bass, Mohammad A. Hasdianda, Gregory Peters, Carlos A. Camargo Jr, Rebecca E. Cash
Summary: Since the publication of the National EMS Research Agenda in 2001, there has been an increase in EMS-specific research and NIH-funded grants. EMS-related publications have tripled and the number of funded EMS research grants has nearly quintupled in the United States over the past 20 years.
ANNALS OF EMERGENCY MEDICINE
(2023)
Article
Medical Informatics
Jeffrey A. Kline, Brian Reed, Alex Frost, Naomi Alanis, Meylakh Barshay, Andrew Melzer, James W. Galbraith, Alicia Budd, Amber Winn, Eugene Pun, Carlos A. Camargo Jr
Summary: This study describes the development and operation of a national network dedicated to surveillance of acute respiratory infections in emergency departments, providing a valuable public health resource for monitoring the epidemiology, viral causes, and outcomes of ED patients with ARIs.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2023)
Article
Virology
Yury A. Bochkov, Mark Devries, Kaitlin Tetreault, Ronald Gangnon, Sujin Lee, Leonard B. Bacharier, William W. Busse, Carlos A. Camargo, Timothy Choi, Robyn Cohen, Ramyani De, Gregory P. DeMuri, Anne M. Fitzpatrick, Peter J. Gergen, Kristine Grindle, Rebecca Gruchalla, Tina Hartert, Kohei Hasegawa, Gurjit K. Khurana Hershey, Patrick Holt, Kiara Homil, Tuomas Jartti, Meyer Kattan, Carolyn Kercsmar, Haejin Kim, Ingrid A. Laing, Peter N. Le Souef, Andrew H. Liu, David T. Mauger, Tressa Pappas, Shilpa J. Patel, Wanda Phipatanakul, Jacqueline Pongracic, Christine Seroogy, Peter D. Sly, Christopher Tisler, Ellen R. Wald, Robert Wood, Robert F. Lemanske, Daniel J. Jackson, James E. Gern
Summary: This study examined cross-neutralization reactions and antibody duration of rhinovirus type A (RV-A) and type C (RV-C). The results showed limited cross-neutralization reactions between the two types, which are limited to genetically similar strains. However, the duration of antibody response during childhood is similar for both types.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Christopher L. Bennett, Allan S. Detsky, Carson E. Clay, Janice A. Espinola, Julie Parsonnet, Carlos A. Camargo
Summary: This study found that emergency departments (EDs) in HIV priority jurisdictions in the United States serve populations emphasized in HIV-related efforts, such as Black or African American or Hispanic or Latino populations, as well as communities with higher proportions uninsured and living in poverty, and higher rates of chlamydia, gonorrhea, and syphilis. EDs with teaching hospital affiliations had the highest visit volumes and steady growth. The findings suggest that geographically targeted screening in EDs with a teaching hospital affiliation could efficiently reach vulnerable populations and reduce the burden of undiagnosed HIV in the US.
Article
Cardiac & Cardiovascular Systems
Geneva D. Mehta, Anna Chen Arroyo, Zhaozhong Zhu, Janice A. Espinola, Jonathan M. Mansbach, Kohei Hasegawa, Carlos A. Camargo Jr
Summary: The history of severe bronchiolitis in infancy is associated with decreased lung function at the age of 6, potentially increasing the risk of chronic respiratory illnesses in the future.
RESPIRATORY MEDICINE
(2023)
Article
Health Care Sciences & Services
Kori S. Zachrison, Rebecca E. Cash, Krislyn M. Boggs, Emily M. Hayden, Ashley F. Sullivan, Carlos A. Camargo Jr
Summary: This study aimed to examine the use of telehealth by US emergency departments (EDs) during COVID-19 and whether existing telehealth infrastructure or increased system integration were associated with increased likelihood of use. The results showed that telehealth use by US EDs in 2020 exceeded expectations and preexisting telehealth infrastructure was associated with increased innovation in its use.
TELEMEDICINE AND E-HEALTH
(2023)