Iron overload induced death of osteoblasts in vitro: involvement of the mitochondrial apoptotic pathway

NADPH oxidases: key modulators in aging and age-related cardiovascular diseases?

(2016) S. Sahoo et al.   CLINICAL SCIENCE

Mitochondrial iron overload: causes and consequences

(2016) Tracey A Rouault   CURRENT OPINION IN GENETICS & DEVELOPMENT

Mechanisms of iron hepatotoxicity

(2016) Antonello Pietrangelo   JOURNAL OF HEPATOLOGY

Activation of GLP-1 Receptor Promotes Bone Marrow Stromal Cell Osteogenic Differentiation through β-Catenin

(2016) Jingru Meng et al.   Stem Cell Reports

Decreased Bone Formation Explains Osteoporosis in a Genetic Mouse Model of Hemochromatosiss

(2016) Mathilde Doyard et al.   PLoS One

Iron and oxidative stress in cardiomyopathy in thalassemia

(2015) Vasilios Berdoukas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial iron and energetic dysfunction distinguish fibroblasts and induced neurons from pantothenate kinase-associated neurodegeneration patients

(2015) Paolo Santambrogio et al.   NEUROBIOLOGY OF DISEASE

Ropivacaine- and bupivacaine-induced death of rabbit annulus fibrosus cells in vitro : involvement of the mitochondrial apoptotic pathway

(2015) X.-Y. Cai et al.   OSTEOARTHRITIS AND CARTILAGE

Iron overload triggers mitochondrial fragmentation via calcineurin-sensitive signals in HT-22 hippocampal neuron cells

(2015) Junghyung Park et al.   TOXICOLOGY

Effects of Iron Overload on the Bone Marrow Microenvironment in Mice

(2015) Yuchen Zhang et al.   PLoS One

ROS-mediated iron overload injures the hematopoiesis of bone marrow by damaging hematopoietic stem/progenitor cells in mice

(2015) Xiao Chai et al.   Scientific Reports

NADPH oxidases in bone homeostasis and osteoporosis

(2014) Katrin Schröder   CELLULAR AND MOLECULAR LIFE SCIENCES

The interplay between mitochondrial protein and iron homeostasis and its possible role in ageing

(2014) Venkatesh Mallikarjun et al.   EXPERIMENTAL GERONTOLOGY

Thalassemia Bone Disease: A 19-Year Longitudinal Analysis

(2014) Phillip Wong et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Maintaining the pluripotency of mouse embryonic stem cells on gold nanoparticle layers with nanoscale but not microscale surface roughness

(2014) Zhonglin Lyu et al.   Nanoscale

An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia

(2014) Michael Dussiot et al.   NATURE MEDICINE

Iron Overload and Apoptosis of HL-1 Cardiomyocytes: Effects of Calcium Channel Blockade

(2014) Mei-pian Chen et al.   PLoS One

Metabolic control of cell death

(2014) D. R. Green et al.   SCIENCE

Blockade of mitochondrial calcium uniporter prevents cardiac mitochondrial dysfunction caused by iron overload

(2013) J. Sripetchwandee et al.   Acta Physiologica

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

N-acetyl cysteine as an osteogenesis-enhancing molecule for bone regeneration

(2013) Masahiro Yamada et al.   BIOMATERIALS

Free iron catalyzes oxidative damage to hematopoietic cells/mesenchymal stem cellsin vitroand suppresses hematopoiesis in iron overload patients

(2013) Wenyi Lu et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation

(2013) Seungha Hyeon et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of intracellular labile iron, ferritin, and antioxidant defence in resistance of chronically adapted Jurkat T cells to hydrogen peroxide

(2013) Abdullah Al-Qenaei et al.   FREE RADICAL BIOLOGY AND MEDICINE

Steap4 Plays a Critical Role in Osteoclastogenesisin Vitroby Regulating Cellular Iron/Reactive Oxygen Species (ROS) Levels and cAMP Response Element-binding Protein (CREB) Activation

(2013) Jian Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Measuring apoptosis by microscopy and flow cytometry

(2013) Conor M. Henry et al.   METHODS

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy is activated in compression-induced cell degeneration and is mediated by reactive oxygen species in nucleus pulposus cells exposed to compression

(2013) K.-G. Ma et al.   OSTEOARTHRITIS AND CARTILAGE

Thalassemia bone disease: the association between nephrolithiasis, bone mineral density and fractures

(2013) P. Wong et al.   OSTEOPOROSIS INTERNATIONAL

Mitochondrial Regulation of Cell Death

(2013) S. W. G. Tait et al.   Cold Spring Harbor Perspectives in Biology

Multiple Functions of BCL-2 Family Proteins

(2013) J. M. Hardwick et al.   Cold Spring Harbor Perspectives in Biology

Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells

(2012) Fan Ding et al.   APOPTOSIS

Control over the Gradient Differentiation of Rat BMSCs on a PCL Membrane with Surface-Immobilized Alendronate Gradient

(2012) Yang Zhu et al.   BIOMACROMOLECULES

Iron overload accelerates bone loss in healthy postmenopausal women and middle-aged men: A 3-year retrospective longitudinal study

(2012) Beom-Jun Kim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Transition metals and mitochondrial metabolism in the heart

(2012) Amy K. Rines et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

(2012) Lingling Xian et al.   NATURE MEDICINE

Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass

(2012) Min Guan et al.   NATURE MEDICINE

High body iron stores lead to bone loss

(2012) Fiona Mitchell   Nature Reviews Endocrinology

Iron homeostasis in osteoporosis and its clinical implications

(2012) G. F. Li et al.   OSTEOPOROSIS INTERNATIONAL

Iron excess limits HHIPL-2 gene expression and decreases osteoblastic activity in human MG-63 cells

(2012) M. Doyard et al.   OSTEOPOROSIS INTERNATIONAL

Non-transferrin bound iron: A key role in iron overload and iron toxicity

(2011) Pierre Brissot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Programmed Cell Death in Animal Development and Disease

(2011) Yaron Fuchs et al.   CELL

Cross talk between mitochondria and NADPH oxidases

(2011) Sergey Dikalov   FREE RADICAL BIOLOGY AND MEDICINE

Inhibitory effects of iron on bone morphogenetic protein 2-induced osteoblastogenesis

(2011) Qing Yang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Iron handling in hippocampal neurons: activity-dependent iron entry and mitochondria-mediated neurotoxicity

(2010) Ilaria Pelizzoni et al.   AGING CELL

Treatment options for thalassemia patients with osteoporosis

(2010) Evangelos Terpos et al.   Annals of the New York Academy of Sciences

Bone loss caused by iron overload in a murine model: importance of oxidative stress

(2010) J. Tsay et al.   BLOOD

Bone disease and skeletal complications in patients with β thalassemia major

(2010) Rachid Haidar et al.   BONE

From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis

(2010) Stavros C. Manolagas   ENDOCRINE REVIEWS

Differentiation character of adult mesenchymal stem cells and transfection of MSCs with lentiviral vectors

(2010) Xiayi Zhang et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Iron overload alters iron-regulatory genes and proteins, down-regulates osteoblastic phenotype, and is associated with apoptosis in fetal rat calvaria cultures

(2009) Jonathan G. Messer et al.   BONE

Ferritin ferroxidase activity: A potent inhibitor of osteogenesis

(2009) Abolfazl Zarjou et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Function and biogenesis of iron–sulphur proteins

(2009) Roland Lill   NATURE

Glutathione depletion in immortalized midbrain-derived dopaminergic neurons results in increases in the labile iron pool: Implications for Parkinson's disease

(2008) Deepinder Kaur et al.   FREE RADICAL BIOLOGY AND MEDICINE

Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury

(2008) Akira Uchiyama et al.   HEPATOLOGY

Bone Disease in Thalassemia: A Frequent and Still Unresolved Problem

(2008) Maria G Vogiatzi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Association between iron overload and osteoporosis in patients with hereditary hemochromatosis

(2008) L. Valenti et al.   OSTEOPOROSIS INTERNATIONAL

N-acetylcysteine stimulates osteoblastic differentiation of mouse calvarial cells

(2007) Ji Hae Jun et al.   JOURNAL OF CELLULAR BIOCHEMISTRY