Non-glucose metabolism in cancer cells—is it all in the fat?

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Molecular Evolution of the Metazoan PHD–HIF Oxygen-Sensing System

(2011) Kalle T. Rytkönen et al.   MOLECULAR BIOLOGY AND EVOLUTION

Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells

(2010) Lisa S. Pike et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism

(2010) Z. J. Reitman et al.   JNCI-Journal of the National Cancer Institute

Molecular alterations of the IDH1 gene in AML: a Children's Oncology Group and Southwest Oncology Group study

(2010) P A Ho et al.   LEUKEMIA

Rapamycin Regulates Stearoyl CoA Desaturase 1 Expression in Breast Cancer

(2010) D. Luyimbazi et al.   MOLECULAR CANCER THERAPEUTICS

All the 1p19q codeleted gliomas are mutated on IDH1 or IDH2

(2010) M. Labussiere et al.   NEUROLOGY

Cancer-associated IDH mutations: biomarker and therapeutic opportunities

(2010) K E Yen et al.   ONCOGENE

mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis: Fig. 1.

(2010) Mathieu Laplante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Akt–SREBP nexus: cell signaling meets lipid metabolism

(2010) James R. Krycer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

IDH mutations in glioma and acute myeloid leukemia

(2010) Lenny Dang et al.   TRENDS IN MOLECULAR MEDICINE

The Randle cycle revisited: a new head for an old hat

(2009) Louis Hue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors

(2009) Dmitry O. Koltun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy

(2009) T Mashima et al.   BRITISH JOURNAL OF CANCER

Acyl-CoA Synthetase VL3 Knockdown Inhibits Human Glioma Cell Proliferation and Tumorigenicity

(2009) Z. Pei et al.   CANCER RESEARCH

Mitochondrial Uncoupling and the Warburg Effect: Molecular Basis for the Reprogramming of Cancer Cell Metabolism

(2009) I. Samudio et al.   CANCER RESEARCH

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

Hypoxia-Inducible Factor 2 Regulates Hepatic Lipid Metabolism

(2009) E. B. Rankin et al.   MOLECULAR AND CELLULAR BIOLOGY

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Inhibition of StearoylCoA Desaturase-1 Inactivates Acetyl-CoA Carboxylase and Impairs Proliferation in Cancer Cells: Role of AMPK

(2009) Natalia Scaglia et al.   PLoS One

EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

(2009) D. Guo et al.   Science Signaling

Biochemical and physiological function of stearoyl-CoA desaturase

(2008) Chad M. Paton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Acetyl-Coenzyme A acyltransferase 2 attenuates the apoptotic effects of BNIP3 in two human cell lines

(2008) Wei Cao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Warburg Effect in Leukemia-Stroma Cocultures Is Mediated by Mitochondrial Uncoupling Associated with Uncoupling Protein 2 Activation

(2008) I. Samudio et al.   CANCER RESEARCH

The Mitochondrial Uncoupling Protein-2 Promotes Chemoresistance in Cancer Cells

(2008) Z. Derdak et al.   CANCER RESEARCH

Fatty Acid Synthase Gene Is Up-regulated by Hypoxia via Activation of Akt and Sterol Regulatory Element Binding Protein-1

(2008) E. Furuta et al.   CANCER RESEARCH

Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes

(2008) Manlio Vinciguerra et al.   HEPATOLOGY

Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis

(2008) Bora Gurel et al.   MODERN PATHOLOGY

Gene silencing for epidermal growth factor receptor variant III induces cell-specific cytotoxicity

(2008) F. Yamoutpour et al.   MOLECULAR CANCER THERAPEUTICS

A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction

(2008) H. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Saturated Fatty Acids Modulate Cell Response to DNA Damage: Implication for Their Role in Tumorigenesis

(2008) Li Zeng et al.   PLoS One