Telomerase: The Devil Inside

Reactivation of telomerase in cancer

(2016) Semih Can Akincilar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Understanding TERT Promoter Mutations: A Common Path to Immortality

(2016) R. J. A. Bell et al.   MOLECULAR CANCER RESEARCH

hTERT promotes cell adhesion and migration independent of telomerase activity

(2016) Haiying Liu et al.   Scientific Reports

Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion

(2015) J. K. Meena et al.   EMBO JOURNAL

Mutation of theTERTpromoter, switch to active chromatin, and monoallelicTERTexpression in multiple cancers

(2015) Josh Lewis Stern et al.   GENES & DEVELOPMENT

Telomerase activation by genomic rearrangements in high-risk neuroblastoma

(2015) Martin Peifer et al.   NATURE

Recurrent somatic mutations in regulatory regions of human cancer genomes

(2015) Collin Melton et al.   NATURE GENETICS

The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer

(2015) R. J. A. Bell et al.   SCIENCE

Hotspot TERT promoter mutations are rare events in testicular germ cell tumors

(2015) Flavio Mavignier Cárcano et al.   TUMOR BIOLOGY

Cancer-associated TERT promoter mutations abrogate telomerase silencing

(2015) Kunitoshi Chiba et al.   eLife

Telomerase Inhibition Effectively Targets Mouse and Human AML Stem Cells and Delays Relapse following Chemotherapy

(2014) Claudia Bruedigam et al.   Cell Stem Cell

Low frequency of TERT promoter mutations in gastrointestinal stromal tumors (GISTs)

(2014) Nathália C Campanella et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genome-wide analysis of noncoding regulatory mutations in cancer

(2014) Nils Weinhold et al.   NATURE GENETICS

Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

(2014) Yasushi Totoki et al.   NATURE GENETICS

Telomerase promoter mutations in cancer: an emerging molecular biomarker?

(2014) João Vinagre et al.   VIRCHOWS ARCHIV

Telomerase stimulates ribosomal DNA transcription under hyperproliferative conditions

(2014) Omar Garcia Gonzalez et al.   Nature Communications

TERT promoter mutation and aberrant hypermethylation are associated with elevated expression in medulloblastoma and characterise the majority of non-infant SHH subgroup tumours

(2013) Janet C. Lindsey et al.   ACTA NEUROPATHOLOGICA

TERT Promoter Mutations Occur Early in Urothelial Neoplasia and Are Biomarkers of Early Disease and Disease Recurrence in Urine

(2013) I. Kinde et al.   CANCER RESEARCH

The Major Reverse Transcriptase-Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from Apoptosis

(2013) I. Listerman et al.   CANCER RESEARCH

The Role of Telomeres in Stem Cells and Cancer

(2013) Cagatay Günes et al.   CELL

Highly prevalent TERT promoter mutations in aggressive thyroid cancers

(2013) Xiaoli Liu et al.   ENDOCRINE-RELATED CANCER

Telomerase Reverse Transcriptase Promoter Mutations in Bladder Cancer: High Frequency Across Stages, Detection in Urine, and Lack of Association with Outcome

(2013) Yves Allory et al.   EUROPEAN UROLOGY

Comprehensive Mutation Analysis of the TERT Promoter in Bladder Cancer and Detection of Mutations in Voided Urine

(2013) Carolyn D. Hurst et al.   EUROPEAN UROLOGY

Implications of telomere-independent activities of telomerase reverse transcriptase in human cancer

(2013) Deqiang Ding et al.   FEBS Journal

Tracing the cellular origin of cancer

(2013) Cédric Blanpain   NATURE CELL BIOLOGY

Mitochondrial Telomerase Protects Cancer Cells from Nuclear DNA Damage and Apoptosis

(2013) Chatchawan Singhapol et al.   PLoS One

TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism

(2013) P. S. Rachakonda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

(2013) P. J. Killela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

Frequency of TERT promoter mutations in human cancers

(2013) João Vinagre et al.   Nature Communications

High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

(2013) Jean Charles Nault et al.   Nature Communications

Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer

(2012) Jian Hu et al.   CELL

Telomerase Reactivation following Telomere Dysfunction Yields Murine Prostate Tumors with Bone Metastases

(2012) Zhihu Ding et al.   CELL

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

(2012) John S. Welch et al.   CELL

Understanding telomerase in cancer stem cell biology

(2012) Isidro Sánchez-García   CELL CYCLE

Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions

(2012) Anitha Suram et al.   EMBO JOURNAL

Regulation of the human catalytic subunit of telomerase (hTERT)

(2012) Michael Daniel et al.   GENE

CEBPfactors regulate telomerase reverse transcriptase promoter activity in whey acidic protein-T mice during mammary carcinogenesis

(2012) Mukesh Kumar et al.   INTERNATIONAL JOURNAL OF CANCER

Wnt/ -Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells

(2012) K. Hoffmeyer et al.   SCIENCE

hTERT promoter methylation and telomere length in childhood acute lymphoblastic leukemia—associations with immunophenotype and cytogenetic subgroup

(2011) Magnus Borssén et al.   EXPERIMENTAL HEMATOLOGY

The Promoter of Human Telomerase Reverse Transcriptase Is Activated During Liver Regeneration and Hepatocyte Proliferation

(2011) Hüseyin Sirma et al.   GASTROENTEROLOGY

Phenotypes in mTERT+/- and mTERT-/- Mice Are Due to Short Telomeres, Not Telomere-Independent Functions of Telomerase Reverse Transcriptase

(2011) M. A. Strong et al.   MOLECULAR AND CELLULAR BIOLOGY

Wilms' tumour 1 can suppress hTERT gene expression and telomerase activity in clear cell renal cell carcinoma via multiple pathways

(2010) R T Sitaram et al.   BRITISH JOURNAL OF CANCER

Human telomerase catalytic subunit (hTERT) suppresses p53-mediated anti-apoptotic response via induction of basic fibroblast growth factor

(2010) Xun Jin et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Epigenetic plasticity of hTERT gene promoter determines retinoid capacity to repress telomerase in maturation-resistant acute promyelocytic leukemia cells

(2010) A Azouz et al.   LEUKEMIA

Krüppel-Like Transcription Factor 4 Contributes to Maintenance of Telomerase Activity in Stem Cells

(2010) Chui-Wei Wong et al.   STEM CELLS

Telomere length maintenance in stem cell populations

(2009) Nicholas D. Allen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Telomeres and telomerase in cancer

(2009) S. E. Artandi et al.   CARCINOGENESIS

Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells

(2009) Rosa M. Marion et al.   Cell Stem Cell

Telomerase modulates Wnt signalling by association with target gene chromatin

(2009) Jae-Il Park et al.   NATURE

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase

(2009) Sofia L. Vidal-Cardenas et al.   NUCLEIC ACIDS RESEARCH

A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis

(2009) A. S. Venteicher et al.   SCIENCE

Understanding and exploitinghTERTpromoter regulation for diagnosis and treatment of human cancers

(2008) Satoru Kyo et al.   CANCER SCIENCE

Ets2 Maintains hTERT Gene Expression and Breast Cancer Cell Proliferation by Interacting with c-Myc

(2008) Dakang Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the steps that lead to cancer: Replicative telomere erosion, aneuploidy and an epigenetic maturation arrest of tissue stem cells

(2008) Reinhard Stindl   MEDICAL HYPOTHESES

Differential regulation of human and mousetelomerase reverse transcriptase(TERT) promoter activity during testis development

(2008) J.M. Weise et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

TERT promotes cellular and organismal survival independently of telomerase activity

(2008) J Lee et al.   ONCOGENE

TERT Promotes Epithelial Proliferation through Transcriptional Control of a Myc- and Wnt-Related Developmental Program

(2008) Jinkuk Choi et al.   PLoS Genetics