Role of Platelet-Derived Microvesicles As Crosstalk Mediators in Atherothrombosis and Future Pharmacology Targets: A Link between Inflammation, Atherosclerosis, and Thrombosis

Platelet microparticles inhibit IL-17 production by regulatory T cells through P-selectin

(2016) S. Dinkla et al.   BLOOD

Thrombin Stimulated Platelet-Derived Exosomes Inhibit Platelet-Derived Growth Factor Receptor-Beta Expression in Vascular Smooth Muscle Cells

(2016) Ming Tan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Circulating microparticle signature in coronary and peripheral blood of ST elevation myocardial infarction patients in relation to pain-to-PCI elapsed time

(2016) R. Suades et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

CD3+/CD45+ and SMA-α+ circulating microparticles are increased in individuals at high cardiovascular risk who will develop a major cardiovascular event

(2016) Gemma Chiva-Blanch et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

CD142+/CD61+, CD146+ and CD45+ microparticles predict cardiovascular events in high risk patients following a Mediterranean diet supplemented with nuts

(2016) Gemma Chiva-Blanch et al.   THROMBOSIS AND HAEMOSTASIS

Microparticle Shedding from Neural Progenitor Cells and Vascular Compartment Cells Is Increased in Ischemic Stroke

(2016) Gemma Chiva-Blanch et al.   PLoS One

The influence of statin therapy on platelet activity markers in hyperlipidemic patients after ischemic stroke

(2015) Malgorzata Pawelczyk et al.   Archives of Medical Science

Dynamic microvesicle release and clearance within the cardiovascular system: triggers and mechanisms

(2015) L. Ayers et al.   CLINICAL SCIENCE

Association of the Plasma Platelet-Derived Microparticles to Platelet Count Ratio with Hospital Mortality and Disseminated Intravascular Coagulopathy in Critically Ill Patients

(2015) Masatsugu Ohuchi et al.   Journal of Atherosclerosis and Thrombosis

Levels of Circulating Microparticles in Patients with Chronic Cardiorenal Disease

(2015) Yung-Lung Chen et al.   Journal of Atherosclerosis and Thrombosis

Elevated Level of Circulating Platelet-derived Microparticles in Oral Cancer

(2015) J.G. Ren et al.   JOURNAL OF DENTAL RESEARCH

Quantitative proteomics analysis of platelet-derived microparticles reveals distinct protein signatures when stimulated by different physiological agonists

(2015) Marco Milioli et al.   Journal of Proteomics

Growing thrombi release increased levels of CD235a+microparticles and decreased levels of activated platelet-derived microparticles. Validation in ST-elevation myocardial infarction patients

(2015) R. Suades et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The Role of Blood-Borne Microparticles in Inflammation and Hemostasis

(2015) Rosa Suades et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

High levels of TSP1+/CD142+ platelet-derived microparticles characterise young patients with high cardiovascular risk and subclinical atherosclerosis

(2015) Rosa Suades et al.   THROMBOSIS AND HAEMOSTASIS

Circulating microparticles in patients with antiphospholipid antibodies: Characterization and associations

(2015) Shruti Chaturvedi et al.   THROMBOSIS RESEARCH

Circulating microparticles in umbilical cord blood in normal pregnancy and pregnancy with preeclampsia

(2015) Elena Campello et al.   THROMBOSIS RESEARCH

Platelet-derived microparticles induce polymorphonuclear leukocyte-mediated damage of human pulmonary microvascular endothelial cells

(2015) Ru Feng Xie et al.   TRANSFUSION

Platelet-derived microparticles trigger THP-1 monocytic cell aggregation and release of pro-coagulant tissue factor-expressing microparticles in vitro

(2015) Hsiu-Chen Lin et al.   TRANSFUSION AND APHERESIS SCIENCE

Age- and sex-specific differences in blood-borne microvesicles from apparently healthy humans

(2015) Callie M Gustafson et al.   Biology of Sex Differences

Release of Intracoronary Microparticles during Stent Implantation into Stable Atherosclerotic Lesions under Protection with an Aspiration Device

(2015) Patrick Horn et al.   PLoS One

Correlations of platelet-derived microparticles with thromboxane B2, platelet-activating factor, endothelin-1, and neutrophil to lymphocyte ratio in patients with coronary intermediate lesions

(2014) Yuan I. Scarlet Chou et al.   BIOMARKERS

CLEC-2 expression is maintained on activated platelets and on platelet microparticles

(2014) E. Gitz et al.   BLOOD

Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation

(2014) L. H. Boudreau et al.   BLOOD

Small-size platelet microparticles trigger platelet and monocyte functionality and modulate thrombogenesis via P-selectin

(2014) Silvia Montoro-García et al.   BRITISH JOURNAL OF HAEMATOLOGY

The Influence of Pre-Analytical Conditions on Platelet-Derived Microparticles

(2014) FABIAN ECKSTEIN et al.   Clinical Laboratory

Pathophysiology of Acute Coronary Syndrome

(2014) Carlos G. Santos-Gallego et al.   Current Atherosclerosis Reports

Microparticles and vascular dysfunction in obstructive sleep apnoea

(2014) W. Trzepizur et al.   EUROPEAN RESPIRATORY JOURNAL

Young women with polycystic ovary syndrome have raised levels of circulating annexin V-positive platelet microparticles

(2014) G.R. Willis et al.   HUMAN REPRODUCTION

Thrombosis formation on atherosclerotic lesions and plaque rupture

(2014) L. Badimon et al.   JOURNAL OF INTERNAL MEDICINE

Low level of procoagulant platelet microparticles is associated with impaired coagulation and transfusion requirements in trauma patients

(2014) Nis Agerlin Windeløv et al.   Journal of Trauma and Acute Care Surgery

The Phospholipidomic Signatures of Human Blood Microparticles, Platelets and Platelet-Derived Microparticles: a Comparative HILIC-ESI–MS Investigation

(2014) Ilario Losito et al.   LIPIDS

Plasma Concentration of Platelet-Derived Microparticles Is Related to Painful Vaso-Occlusive Phenotype Severity in Sickle Cell Anemia

(2014) Danitza Nebor et al.   PLoS One

Therapeutic Inflammatory Monocyte Modulation Using Immune-Modifying Microparticles

(2014) D. R. Getts et al.   Science Translational Medicine

Ectosomes released by platelets induce differentiation of CD4+ T cells into T regulatory cells

(2014) Ceylan Eken et al.   THROMBOSIS AND HAEMOSTASIS

Platelet-derived microparticles augment the adhesion and neovascularization capacities of circulating angiogenic cells obtained from atherosclerotic patients

(2013) Masanori Ohtsuka et al.   ATHEROSCLEROSIS

Activated platelets can deliver mRNA regulatory Ago2bulletmicroRNA complexes to endothelial cells via microparticles

(2013) B. Laffont et al.   BLOOD

Platelets activated during myocardial infarction release functional miRNA, which can be taken up by endothelial cells and regulate ICAM1 expression

(2013) O. Gidlof et al.   BLOOD

MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease

(2013) Maarten Hulsmans et al.   CARDIOVASCULAR RESEARCH

Blebs produced by actin–myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs

(2013) G R Wickman et al.   CELL DEATH AND DIFFERENTIATION

Platelet-Derived Microparticles are Implicated in Remote Ischemia Conditioning in a Rat Model of Cerebral Infarction

(2013) Li-Yang Shan et al.   CNS Neuroscience & Therapeutics

Plasmatic Level of Leukocyte-Derived Microparticles Is Associated With Unstable Plaque in Asymptomatic Patients With High-Grade Carotid Stenosis

(2013) Gabrielle Sarlon-Bartoli et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status

(2013) Xuguang Zhang et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Microparticles in Health and Disease

(2013) J.M. Herring et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Circulating microparticles in patients with coronary heart disease and its correlation with interleukin-6 and C-reactive protein

(2013) Ying Cui et al.   MOLECULAR BIOLOGY REPORTS

Platelet microparticles: reinforcing the hegemony of platelets in atherothrombosis

(2013) S. F. Mause   THROMBOSIS AND HAEMOSTASIS

Lipid-lowering therapy with statins reduces microparticle shedding from endothelium, platelets and inflammatory cells

(2013) Rosa Suades et al.   THROMBOSIS AND HAEMOSTASIS

Circulating CD45+/CD3+ lymphocyte-derived microparticles map lipid-rich atherosclerotic plaques in familial hypercholesterolaemia patients

(2013) R. Suades et al.   THROMBOSIS AND HAEMOSTASIS

Differences in Microparticle Release in Patients With Acute Coronary Syndrome and Stable Angina

(2012) Luigi Marzio Biasucci et al.   CIRCULATION JOURNAL

Platelet-Derived Microparticles and Platelet Function Profile in Children With Congenital Heart Disease

(2012) Eman Abdel Rahman Ismail et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Platelet Microparticles Induce Angiogenesis and Neurogenesis after Cerebral Ischemia

(2012) Yael Hayon et al.   CURRENT NEUROVASCULAR RESEARCH

MicroRNAs in Platelet Biogenesis and Function: Implications in Vascular Homeostasis and Inflammation

(2012) Aikaterini Gatsiou et al.   Current Vascular Pharmacology

The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes

(2012) Nathalie Cloutier et al.   EMBO Molecular Medicine

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

(2012) Patricia Bastos-Amador et al.   Journal of Proteomics

Comparative analysis of platelet-derived microparticles reveals differences in their amount and proteome depending on the platelet stimulus

(2012) Ela Shai et al.   Journal of Proteomics

Enhanced platelet-derived microparticle formation is associated with carotid atherosclerosis in convalescent stroke patients

(2012) Maria Lukasik et al.   PLATELETS

Role of platelets as mediators that link inflammation and thrombosis in atherosclerosis

(2012) Eduardo Fuentes Q. et al.   PLATELETS

Platelet-Derived Microvesicles: Multitalented Participants in Intercellular Communication

(2012) Maria Aatonen et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Circulating and platelet-derived microparticles in human blood enhance thrombosis on atherosclerotic plaques

(2012) Rosa Suades et al.   THROMBOSIS AND HAEMOSTASIS

Platelet-derived microparticles during and after acute coronary syndrome

(2012) Fariborz Mobarrez et al.   THROMBOSIS AND HAEMOSTASIS

Platelet-associated tissue factor enhances platelet reactivity and thrombin generation in experimental studies in vitro

(2012) Irene Lopez-Vilchez et al.   THROMBOSIS RESEARCH

Involvement of platelet derived microparticles in tumor metastasis and tissue regeneration

(2012) David Varon et al.   THROMBOSIS RESEARCH

Circulating endothelial and platelet derived microparticles reflect the size of myocardium at risk in patients with ST-elevation myocardial infarction

(2011) Christian Jung et al.   ATHEROSCLEROSIS

Complement activation on platelet-leukocyte complexes and microparticles in enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome

(2011) A.-l. Stahl et al.   BLOOD

Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis

(2011) E. M. Battinelli et al.   BLOOD

Acetylsalicylate reduces endothelial and platelet-derived microparticles in patients with coronary artery disease

(2011) Daniel Bulut et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Endothelial Progenitor Cell Mobilization and Platelet Microparticle Release Are Influenced by Clopidogrel Plasma Levels in Stable Coronary Artery Disease

(2011) Carolina N. França et al.   CIRCULATION JOURNAL

Plasma Level of Platelet-Derived Microparticles Is Associated with Coronary Heart Disease Risk Score in Healthy Men

(2011) Tetsuya Ueba et al.   Journal of Atherosclerosis and Thrombosis

A filtration-based protocol to isolate human Plasma Membrane-derived Vesicles and exosomes from blood plasma

(2011) Ryan Grant et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Microparticles (Ectosomes) Shed by Stored Human Platelets Downregulate Macrophages and Modify the Development of Dendritic Cells

(2011) S. Sadallah et al.   JOURNAL OF IMMUNOLOGY

Lipopolysaccharide Signaling without a Nucleus: Kinase Cascades Stimulate Platelet Shedding of Proinflammatory IL-1 -Rich Microparticles

(2011) G. T. Brown et al.   JOURNAL OF IMMUNOLOGY

Differential contributions of monocyte- and platelet-derived microparticles towards thrombin generation and fibrin formation and stability

(2011) M. M. ALEMAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Increased levels of platelet activation markers are positively associated with carotid wall thickness and other atherosclerotic risk factors in obese patients

(2011) Bela Nagy et al.   THROMBOSIS AND HAEMOSTASIS

Atorvastatin reduces thrombin generation and expression of tissue factor, P-selectin and GPIIIa on platelet-derived microparticles in patients with peripheral arterial occlusive disease

(2011) Fariborz Mobarrez et al.   THROMBOSIS AND HAEMOSTASIS

Microparticles from apoptotic platelets promote resident macrophage differentiation

(2011) E M Vasina et al.   Cell Death & Disease

The platelet interior revisited: electron tomography reveals tubular  -granule subtypes

(2010) H. van Nispen tot Pannerden et al.   BLOOD

Tissue factor expression on platelets is a dynamic event

(2010) M. Camera et al.   BLOOD

Platelet Microparticles Enhance the Vasoregenerative Potential of Angiogenic Early Outgrowth Cells After Vascular Injury

(2010) Sebastian F. Mause et al.   CIRCULATION

Low dose acetylsalicylic acid and shedding of microparticles in vivo in humans

(2010) Barbara Lubsczyk et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Intervention with education and exercise reverses the metabolic syndrome in adults

(2010) Verónica Mujica et al.   Journal of the American Society of Hypertension

Internalization of microparticles by endothelial cells promotes platelet/endothelial cell interaction under flow

(2010) A. D. TERRISSE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Increased levels of microparticles originating from endothelial cells, platelets and erythrocytes in subjects with metabolic syndrome: Relationship with oxidative stress

(2010) O. Helal et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

(2010) E. Boilard et al.   SCIENCE

Proteomic and functional characterization of platelet microparticle size classes

(2010) William L. Dean et al.   THROMBOSIS AND HAEMOSTASIS

Phagocytosis of platelet microvesicles and β2– glycoprotein I

(2010) Anhquyen Le et al.   THROMBOSIS AND HAEMOSTASIS

Relationship between degree of P2Y12 receptor blockade and inhibition of P2Y12-mediated platelet function

(2010) Robert Buckland et al.   THROMBOSIS AND HAEMOSTASIS

The majority of circulating platelet-derived microparticles fail to bind annexin V, lack phospholipid-dependent procoagulant activity and demonstrate greater expression of glycoprotein Ib

(2010) Thomas Exner et al.   THROMBOSIS AND HAEMOSTASIS

Cellular origin of platelet-derived microparticles in vivo

(2010) Andreas Rank et al.   THROMBOSIS RESEARCH

Atorvastatin has antithrombotic effects in patients with type 1 diabetes and dyslipidemia

(2010) Sara Tehrani et al.   THROMBOSIS RESEARCH

Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures

(2009) M. Prokopi et al.   BLOOD

Detection of the procoagulant activity of microparticle-associated phosphatidylserine using XACT

(2009) David E Connor et al.   BLOOD COAGULATION & FIBRINOLYSIS

Evaluation of Factors Associated With Elevated Levels of Platelet-Derived Microparticles in the Acute Phase of Cerebral Infarction

(2009) Nagato Kuriyama et al.   CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS

Leukocyte- and platelet-derived microparticles correlate with thrombus weight and tissue factor activity in an experimental mouse model of venous thrombosis

(2009) Eduardo Ramacciotti et al.   THROMBOSIS AND HAEMOSTASIS

Characterization of blood borne microparticles as markers of premature coronary calcification in newly menopausal women

(2008) Muthuvel Jayachandran et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Platelet microparticle-associated protein disulfide isomerase promotes platelet aggregation and inactivates insulin

(2008) Arun Raturi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles

(2008) R. Flaumenhaft et al.   BLOOD

Lactadherin and clearance of platelet-derived microvesicles

(2008) S. K. Dasgupta et al.   BLOOD

CD31+/Annexin V+ microparticles in healthy offsprings of patients with coronary artery disease

(2008) D. Bulut et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Platelet microparticles contain active caspase 3

(2008) Anita N. Böing et al.   PLATELETS

Increased level of platelet microparticles in survivors of myocardial infarction

(2008) Annika E. Michelsen et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Internalization of tissue factor by platelets

(2008) Gines Escolar et al.   THROMBOSIS RESEARCH

Increased circulating platelet-derived microparticles are associated with stent-induced vascular inflammation

(2007) Teruo Inoue et al.   ATHEROSCLEROSIS

Role of P2Y receptor subtypes in platelet-derived microparticle generation

(2007) Bryan et al.   Frontiers in Bioscience-Landmark