Comparative Gene Expression Analysis of Two Mouse Models of Autism: Transcriptome Profiling of the BTBR and En2−/− Hippocampus

Advancing the understanding of autism disease mechanisms through genetics

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Sodium butyrate attenuates social behavior deficits and modifies the transcription of inhibitory/excitatory genes in the frontal cortex of an autism model

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Astrocytes and Microglia and Their Potential Link with Autism Spectrum Disorders

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Epilepsy and Autism

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Inflammatory profiles in the BTBR mouse: How relevant are they to autism spectrum disorders?

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Engrailed-2(En2) deletion produces multiple neurodevelopmental defects in monoamine systems, forebrain structures and neurogenesis and behavior

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Neural transcriptome of constitutional Pten dysfunction in mice and its relevance to human idiopathic autism spectrum disorder

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Serotonin abnormalities in Engrailed-2 knockout mice: New insight relevant for a model of Autism Spectrum Disorder

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Hippocampal dysregulation of FMRP/mGluR5 signaling in engrailed-2 knockout mice

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Behavioral and Neuroanatomical Phenotypes in Mouse Models of Autism

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Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures

(2015) Daria Prilutsky et al.   Molecular Autism

Hippocampal Transcriptomic and Proteomic Alterations in the BTBR Mouse Model of Autism Spectrum Disorder

(2015) Caitlin M. Daimon et al.   Frontiers in Physiology

Hippocampal Dysregulation of Neurofibromin-Dependent Pathways Is Associated with Impaired Spatial Learning in Engrailed 2 Knock-Out Mice

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Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity

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Autism Associated Gene, ENGRAILED2, and Flanking Gene Levels Are Altered in Post-Mortem Cerebellum

(2014) Jiyeon Choi et al.   PLoS One

Altered GABAergic markers, increased binocularity and reduced plasticity in the visual cortex of Engrailed-2 knockout mice

(2014) Manuela Allegra et al.   Frontiers in Cellular Neuroscience

Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism

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Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum

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Recent developments in the genetics of autism spectrum disorders

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Loss of GABAergic neurons in the hippocampus and cerebral cortex of Engrailed-2 null mutant mice: Implications for autism spectrum disorders

(2013) Paola Sgadò et al.   EXPERIMENTAL NEUROLOGY

Chronic desipramine treatment rescues depression-related, social and cognitive deficits inEngrailed-2knockout mice

(2013) J. Brielmaier et al.   GENES BRAIN AND BEHAVIOR

The maternal autoimmune environment affects the social behavior of offspring

(2013) Yubin Zhang et al.   JOURNAL OF NEUROIMMUNOLOGY

CNVs conferring risk of autism or schizophrenia affect cognition in controls

(2013) Hreinn Stefansson et al.   NATURE

Quantitative Trait Loci for Interhemispheric Commissure Development and Social Behaviors in the BTBR T+ tf/J Mouse Model of Autism

(2013) Dorothy M. Jones-Davis et al.   PLoS One

Transcriptome profiling in engrailed-2 mutant mice reveals common molecular pathways associated with autism spectrum disorders

(2013) Paola Sgadò et al.   Molecular Autism

Complex epigenetic regulation of Engrailed-2 (EN-2) homeobox gene in the autism cerebellum

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Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice

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Inflammatory macrophage phenotype in BTBR T+tf/J mice

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Reduced social interaction, behavioural flexibility and BDNF signalling in the BTBR T+tf/J strain, a mouse model of autism

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Autism-Relevant Social Abnormalities and Cognitive Deficits in Engrailed-2 Knockout Mice

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Microglial Activation in Young Adults With Autism Spectrum Disorder

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FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

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Transcriptomic analysis of autistic brain reveals convergent molecular pathology

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Aberrant Immune Responses in a Mouse with Behavioral Disorders

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Histopathologic characterization of the BTBR mouse model of autistic-like behavior reveals selective changes in neurodevelopmental proteins and adult hippocampal neurogenesis

(2011) Diane T Stephenson et al.   Molecular Autism

Behavioural phenotyping assays for mouse models of autism

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Autism-Associated Haplotype Affects the Regulation of the Homeobox Gene, ENGRAILED 2

(2009) Rym Benayed et al.   BIOLOGICAL PSYCHIATRY

Elevated immune response in the brain of autistic patients

(2009) Xiaohong Li et al.   JOURNAL OF NEUROIMMUNOLOGY

Increased susceptibility to kainic acid–induced seizures in Engrailed-2 knockout mice

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Comparative genomics of autism and schizophrenia

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The Mouse Genome Database genotypes::phenotypes

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Unusual Repertoire of Vocalizations in the BTBR T+tf/J Mouse Model of Autism

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