Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum

Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain

(2014) Lu Wen et al.   GENOME BIOLOGY

Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum

(2014) A Zhubi et al.   Translational Psychiatry

Epigenetic changes in the progression of Alzheimer's disease

(2013) M.A. Bradley-Whitman et al.   MECHANISMS OF AGEING AND DEVELOPMENT

TET enzymatic oxidation of 5-methylcytosine, 5-hydroxymethylcytosine and 5-formylcytosine

(2013) Jean Cadet et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

(2013) William A. Pastor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain

(2013) Natacha Coppieters et al.   NEUROBIOLOGY OF AGING

Global Epigenomic Reconfiguration During Mammalian Brain Development

(2013) R. Lister et al.   SCIENCE

Dynamics of 5-Hydroxymethylcytosine and Chromatin Marks in Mammalian Neurogenesis

(2013) Maria A. Hahn et al.   Cell Reports

Complex epigenetic regulation of Engrailed-2 (EN-2) homeobox gene in the autism cerebellum

(2013) S J James et al.   Translational Psychiatry

MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System

(2012) Marian Mellén et al.   CELL

Consensus Paper: Pathological Role of the Cerebellum in Autism

(2012) S. Hossein Fatemi et al.   CEREBELLUM

The Mammaliande NovoDNA Methyltransferases DNMT3A and DNMT3B Are Also DNA 5-Hydroxymethylcytosine Dehydroxymethylases

(2012) Chun-Chang Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engrailed Is Required in Maturing Serotonin Neurons to Regulate the Cytoarchitecture and Survival of the Dorsal Raphe Nucleus

(2012) S. R. Fox et al.   JOURNAL OF NEUROSCIENCE

Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation

(2012) Hideharu Hashimoto et al.   NUCLEIC ACIDS RESEARCH

Dynamic hydroxymethylation of deoxyribonucleic acid marks differentiation-associated enhancers

(2012) Aurélien A. Sérandour et al.   NUCLEIC ACIDS RESEARCH

Sensitive periods in epigenetics: bringing us closer to complex behavioral phenotypes

(2012) Corina Nagy et al.   Epigenomics

5-Hydroxymethylcytosine Is Strongly Depleted in Human Cancers but Its Levels Do Not Correlate with IDH1 Mutations

(2011) S.-G. Jin et al.   CANCER RESEARCH

Hypothesis: Environmental regulation of 5-hydroxymethylcytosine by oxidative stress

(2011) Nancy Chia et al.   Epigenetics

Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells

(2011) H. Wu et al.   GENES & DEVELOPMENT

The cerebellum and neuropsychological functioning: A critical review

(2011) Christopher J. O'Halloran et al.   JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

(2011) William A. Pastor et al.   NATURE

5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

(2011) Keith E Szulwach et al.   NATURE NEUROSCIENCE

MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9/H3K27 methylated nucleosomes in the brain

(2011) Anita A. Thambirajah et al.   NUCLEIC ACIDS RESEARCH

Relationship between Gene Body DNA Methylation and Intragenic H3K9me3 and H3K36me3 Chromatin Marks

(2011) Maria A. Hahn et al.   PLoS One

Autism: A “Critical Period” Disorder?

(2011) Jocelyn J. LeBlanc et al.   NEURAL PLASTICITY

Downstream targets of methyl CpG binding protein 2 and their abnormal expression in the frontal cortex of the human Rett syndrome brain

(2010) Joanne H Gibson et al.   BMC NEUROSCIENCE

The Engrailed homeobox genes determine the different foliation patterns in the vermis and hemispheres of the mammalian cerebellum

(2010) Y. Cheng et al.   DEVELOPMENT

Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine

(2010) Seung-Gi Jin et al.   NUCLEIC ACIDS RESEARCH

Autism-Associated Haplotype Affects the Regulation of the Homeobox Gene, ENGRAILED 2

(2009) Rym Benayed et al.   BIOLOGICAL PSYCHIATRY

Increase in Cerebellar Neurotrophin-3 and Oxidative Stress Markers in Autism

(2009) Elizabeth M. Sajdel-Sulkowska et al.   CEREBELLUM

Analysis of 7,8-Dihydro-8-oxo-2′-deoxyguanosine in Cellular DNA during Oxidative Stress

(2009) Dipti Mangal et al.   CHEMICAL RESEARCH IN TOXICOLOGY

8-hydroxy-2′ -deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis

(2009) ATHANASIOS VALAVANIDIS et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Genomic views of distant-acting enhancers

(2009) Axel Visel et al.   NATURE

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet

(2008) Igor P. Pogribny et al.   BRAIN RESEARCH

Engrailed-2 regulates genes related to vesicle formation and transport in cerebellar Purkinje cells

(2008) Martin I. Holst et al.   MOLECULAR AND CELLULAR NEUROSCIENCE