Human IL-22 binding protein isoforms act as a rheostat for IL-22 signaling

Donor interleukin-22 and host type I interferon signaling pathway participate in intestinal graft-versus-host disease via STAT1 activation and CXCL10

(2015) B Lamarthée et al.   Mucosal Immunology

IL-22BP is produced by eosinophils in human gut and blocks IL-22 protective actions during colitis

(2015) J C Martin et al.   Mucosal Immunology

Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection

(2015) Pedro P Hernández et al.   NATURE IMMUNOLOGY

Biologically active, high levels of interleukin-22 inhibit hepatic gluconeogenesis but do not affect obesity and its metabolic consequences

(2015) Ogyi Park et al.   Cell and Bioscience

The role of the IL-22/IL-22R1 axis in cancer

(2014) Chrissie Lim et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The multiple sclerosis risk gene IL22RA2 contributes to a more severe murine autoimmune neuroinflammation

(2014) H Laaksonen et al.   GENES AND IMMUNITY

TLR2-Dependent Activation of β-Catenin Pathway in Dendritic Cells Induces Regulatory Responses and Attenuates Autoimmune Inflammation

(2014) Indumathi Manoharan et al.   JOURNAL OF IMMUNOLOGY

Conventional NK Cells Can Produce IL-22 and Promote Host Defense in Klebsiella pneumoniae Pneumonia

(2014) X. Xu et al.   JOURNAL OF IMMUNOLOGY

Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness

(2014) Joseph M. Pickard et al.   NATURE

Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

(2014) Xiaoting Wang et al.   NATURE

Assessment of microRNA-related SNP effects in the 3′ untranslated region of the IL22RA2 risk locus in multiple sclerosis

(2014) Christina M. Lill et al.   NEUROGENETICS

Homeostatic IL-23 receptor signaling limits Th17 response through IL-22-mediated containment of commensal microbiota

(2014) V. F.-S. Shih et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

(2014) Y. Goto et al.   SCIENCE

IL-22 Is Essential for Lung Epithelial Repair following Influenza Infection

(2013) Derek A. Pociask et al.   AMERICAN JOURNAL OF PATHOLOGY

Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid

(2013) J CJ Martin et al.   Mucosal Immunology

IFNα converts IL-22 into a cytokine efficiently activating STAT1 and its downstream targets

(2012) Malte Bachmann et al.   BIOCHEMICAL PHARMACOLOGY

The mRNA expression profile of cytokines connected to the regulation of melanocyte functioning in vitiligo skin biopsy samples and peripheral blood mononuclear cells

(2012) Ene Reimann et al.   HUMAN IMMUNOLOGY

Retinoic acid regulates the development of a gut-homing precursor for intestinal dendritic cells

(2012) R Zeng et al.   Mucosal Immunology

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

(2012) Samuel Huber et al.   NATURE

Intracellular Overexpression of HIV-1 Nef Impairs Differentiation and Maturation of Monocytic Precursors towards Dendritic Cells

(2012) Yan Guo et al.   PLoS One

Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial

(2011) R. Wade et al.   HAEMATOLOGICA

Interleukin-22 promotes human hepatocellular carcinoma by activation of STAT3

(2011) Runqiu Jiang et al.   HEPATOLOGY

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis

(2010) S. J. MARTIN et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: Role of signal transducer and activator of transcription 3

(2010) Sung Hwan Ki et al.   HEPATOLOGY

IL-22RA2 Associates with Multiple Sclerosis and Macrophage Effector Mechanisms in Experimental Neuroinflammation

(2010) A. D. Beyeen et al.   JOURNAL OF IMMUNOLOGY

Deficiency of IL-22 Contributes to a Chronic Inflammatory Disease: Pathogenetic Mechanisms in Acne Inversa

(2010) K. Wolk et al.   JOURNAL OF IMMUNOLOGY

Crystal structure of a soluble decoy receptor IL-22BP bound to interleukin-22

(2009) Patricia Ribeiro de Moura et al.   FEBS LETTERS

Toll-like receptor 2–dependent induction of vitamin A–metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity

(2009) Santhakumar Manicassamy et al.   NATURE MEDICINE

Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways

(2008) K.E. Nograles et al.   BRITISH JOURNAL OF DERMATOLOGY

Murine NKT cells produce Th17 cytokine interleukin-22

(2008) Megumi Goto et al.   CELLULAR IMMUNOLOGY

Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22

(2008) Hiroaki Takatori et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-22R, IL-10R2, and IL-22BP Binding Sites Are Topologically Juxtaposed on Adjacent and Overlapping Surfaces of IL-22

(2008) Paul W. Wu et al.   JOURNAL OF MOLECULAR BIOLOGY

RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells

(2008) Stephanie L Sanos et al.   NATURE IMMUNOLOGY

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

(2008) Shean J Aujla et al.   NATURE MEDICINE

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE

Structure of IL-22 Bound to Its High-Affinity IL-22R1 Chain

(2008) Brandi C. Jones et al.   STRUCTURE